ENSMUSG00000022831


Mus musculus

Features
Gene ID: ENSMUSG00000022831
  
Biological name :Hcls1
  
Synonyms : Hcls1 / Hematopoietic lineage cell-specific protein / P49710
  
Possible biological names infered from orthology : hematopoietic cell-specific Lyn substrate 1 / P14317
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B3
Gene start: 36934983
Gene end: 36963212
  
Corresponding Affymetrix probe sets: 10435565 (MoGene1.0st)   1418842_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127186
Ensembl peptide - ENSMUSP00000023531
NCBI entrez gene - 15163     See in Manteia.
MGI - MGI:104568
RefSeq - NM_008225
RefSeq Peptide - NP_032251
swissprot - E9Q4E5
swissprot - P49710
Ensembl - ENSMUSG00000022831
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hcls1ENSDARG00000012729Danio rerio
 HCLS1ENSGALG00000039682Gallus gallus
 HCLS1ENSG00000180353Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cttn / Q60598 / cortactin / Q14247*ENSMUSG0000003107848
Dbnl / Q62418 / Drebrin-like protein / Q9UJU6* / drebrin like*ENSMUSG0000002047619
Dbn1 / Q9QXS6 / Drebrin / Q16643* / drebrin 1*ENSMUSG0000003467515


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR003134  Hs1/Cortactin
 IPR028534  Hematopoietic lineage cell-specific protein
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0009725 response to hormone IDA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0030041 actin filament polymerization IEA
 biological_processGO:0030218 erythrocyte differentiation IMP
 biological_processGO:0030833 regulation of actin filament polymerization IEA
 biological_processGO:0030854 positive regulation of granulocyte differentiation IMP
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IMP
 biological_processGO:0042993 obsolete positive regulation of transcription factor import into nucleus IEA
 biological_processGO:0045651 positive regulation of macrophage differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0071345 cellular response to cytokine stimulus IEA
 biological_processGO:2000107 negative regulation of leukocyte apoptotic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017124 SH3 domain binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Pycardtm1Vmd/Pycardtm1Vmd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hcls1tm2Wtn/Hcls1tm2Wtn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pycardtm1Vmd/Pycardtm1Vmd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hcls1tm2Wtn/Hcls1tm2Wtn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004918 abnormal negative T cell selection "any anomaly in the process of elimination of immature T cells which react strongly with self-antigens" [GO:0043383]
Show

Allelic Composition: Hcls1tm2Wtn/Hcls1tm2Wtn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pycardtm1Vmd/Pycardtm1Vmd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hcls1tm2Wtn/Hcls1tm2Wtn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Hcls1tm2Wtn/Hcls1tm2Wtn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Pycardtm1Vmd/Pycardtm1Vmd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hcls1tm2Wtn/Hcls1tm2Wtn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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