ENSMUSG00000022838


Mus musculus

Features
Gene ID: ENSMUSG00000022838
  
Biological name :Eaf2
  
Synonyms : Eaf2 / ELL-associated factor 2 / Q91ZD6
  
Possible biological names infered from orthology : Q96CJ1
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B3
Gene start: 36792884
Gene end: 36875003
  
Corresponding Affymetrix probe sets: 10439346 (MoGene1.0st)   1422120_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023537
Ensembl peptide - ENSMUSP00000075331
Ensembl peptide - ENSMUSP00000110473
Ensembl peptide - ENSMUSP00000110477
NCBI entrez gene - 106389     See in Manteia.
MGI - MGI:2146616
RefSeq - XM_011245800
RefSeq - NM_001113401
RefSeq - NM_001113405
RefSeq - NM_134111
RefSeq - XM_006521682
RefSeq - XM_006521683
RefSeq - XM_006521684
RefSeq - XM_006521685
RefSeq - XM_006521686
RefSeq - XM_011245799
RefSeq Peptide - NP_001106872
RefSeq Peptide - NP_001106876
RefSeq Peptide - NP_001345031
RefSeq Peptide - NP_598872
swissprot - Q91ZD6
swissprot - K4DI60
Ensembl - ENSMUSG00000022838
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eaf2ENSDARG00000010432Danio rerio
 EAF2ENSGALG00000011657Gallus gallus
 EAF2ENSG00000145088Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eaf1 / Q9D4C5 / ELL-associated factor 1 / Q96JC9*ENSMUSG0000002189053


Protein motifs (from Interpro)
Interpro ID Name
 IPR019194  Transcription elognation factor Eaf, N-terminal
 IPR027093  EAF family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0030308 negative regulation of cell growth IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development IMP
 biological_processGO:0097193 intrinsic apoptotic signaling pathway ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0008023 transcription elongation factor complex ISO
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0032783 ELL-EAF complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Transcription Elongation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Slc4a1tm1Dmb/Slc4a1tm1Dmb
Genetic Background: involves: 129S6/SvEvTac

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Slc4a1tm1Dmb/Slc4a1tm1Dmb
Genetic Background: involves: 129S6/SvEvTac

 MP:0001158 abnormal prostate morphology "mallformed gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
Show

Allelic Composition: Slc4a1tm1Dmb/Slc4a1tm1Dmb
Genetic Background: involves: 129S6/SvEvTac

 MP:0001168 prostate epithelial dysplasia "abnormal development of the prostate epithelium" [J:63764]
Show

Allelic Composition: Slc4a1tm1Dmb/Slc4a1tm1Dmb
Genetic Background: involves: 129S6/SvEvTac

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Slc4a1tm1Dmb/Slc4a1tm1Dmb
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Eaf2tm1Zhow/Eaf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Slc4a1tm1Dmb/Slc4a1tm1Dmb
Genetic Background: involves: 129S6/SvEvTac

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Slc4a1tm1Dmb/Slc4a1tm1Dmb
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Eaf2tm1Zhow/Eaf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc4a1tm1Dmb/Slc4a1tm1Dmb
Genetic Background: involves: 129S6/SvEvTac

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Slc4a1tm1Dmb/Slc4a1tm1Dmb
Genetic Background: involves: 129S6/SvEvTac

 MP:0004961 increased prostate weight "greater than average weight of the gland in males that secretes part of the seminiferous fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc4a1tm1Dmb/Slc4a1tm1Dmb
Genetic Background: involves: 129S6/SvEvTac

 MP:0009219 prostate intraepithelial neoplasia "noninvasive prostate duct lesions that affect smaller caliber ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc4a1tm1Dmb/Slc4a1tm1Dmb
Genetic Background: involves: 129S6/SvEvTac

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc4a1tm1Dmb/Slc4a1tm1Dmb
Genetic Background: involves: 129S6/SvEvTac

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Eaf2tm1Zhow/Eaf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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