ENSMUSG00000022991


Mus musculus
lactosebindingLalbaglycosidehydrolasefamilyprocessdefenseresponsebacteriumextracellularactivityionlactalbuminconservedsitelysozyme-likedomainsuperfamilybiosyntheticcellwallmacromoleculecatabolicgram-negativegram-positiveregionspacelysozymesynthasecalcium

Features
Gene ID: ENSMUSG00000022991
  
Biological name :Lalba
  
Synonyms : Alpha-lactalbumin / Lalba / P29752
  
Possible biological names infered from orthology : lactalbumin alpha / P00709
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F1
Gene start: 98480400
Gene end: 98482721
  
Corresponding Affymetrix probe sets: 10432157 (MoGene1.0st)   1418363_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023726
NCBI entrez gene - 16770     See in Manteia.
MGI - MGI:96742
RefSeq - XM_006520517
RefSeq - NM_010679
RefSeq Peptide - NP_034809
swissprot - P29752
swissprot - A0A077S9Z6
Ensembl - ENSMUSG00000022991
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LALBAENSG00000167531Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lyz1 / P17897 / Lysozyme C-1 / LYZ* / P61626* / lysozyme*ENSMUSG0000006951536
Q9D9X8 / Spaca3 / Mus musculus sperm acrosome associated 3 (Spaca3), transcript variant 1, mRNA. / Q8IXA5* / sperm acrosome associated 3*ENSMUSG0000005318435
Lyz2 / P08905 / lysozyme 2 / LYZ* / P61626* / lysozyme*ENSMUSG0000006951635
Lyzl4 / Q9D925 / lysozyme-like 4 / Q96KX0*ENSMUSG0000003253034
Lyzl1 / Q9CPX3 / Lysozyme-like protein 1 / LYZL2* / Q6UWQ5* / Q7Z4W2* / lysozyme like 2* / lysozyme like 1*ENSMUSG0000002423332
9530003J23Rik / RIKEN cDNA 9530003J23 gene / LYZ* / P61626* / lysozyme*ENSMUSG0000002017731
Lyzl6 / Q9DA11 / Mus musculus lysozyme-like 6 (Lyzl6), transcript variant 2, mRNA. / O75951* / lysozyme like 6*ENSMUSG0000002094531
Spaca5 / A2AE20 / sperm acrosome associated 5 / Q96QH8* / SPACA5B* / sperm acrosome associated 5B*ENSMUSG0000003716729


Protein motifs (from Interpro)
Interpro ID Name
 IPR000545  Lactalbumin
 IPR001916  Glycoside hydrolase, family 22
 IPR019799  Glycoside hydrolase, family 22, conserved site
 IPR023346  Lysozyme-like domain superfamily


Gene Ontology (GO)
biosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcell wall organization or biogenesisresponse to stressresponse to external stimulusresponse to biotic stimulusbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcell wall organization or biogenesisresponse to stressresponse to external stimulusresponse to biotic stimulusbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcell wall organization or biogenesisresponse to stressresponse to external stimulusresponse to biotic stimulusbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcell wall organization or biogenesisresponse to stressresponse to external stimulusresponse to biotic stimulusbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcell wall organization or biogenesisresponse to stressresponse to external stimulusresponse to biotic stimulusbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcell wall organization or biogenesisresponse to stressresponse to external stimulusresponse to biotic stimulusbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcell wall organization or biogenesisresponse to stressresponse to external stimulusresponse to biotic stimulusbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcell wall organization or biogenesisresponse to stressresponse to external stimulusresponse to biotic stimulusbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcell wall organization or biogenesisresponse to stressresponse to external stimulusresponse to biotic stimulusbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcell wall organization or biogenesisresponse to stressresponse to external stimulusresponse to biotic stimulusbiosynthetic prbiosynthetic processcellular metabocellular metabolic processprimary metabolprimary metabolic processorganic substanorganic substance metabolic processcatabolic procecatabolic processcell wall organcell wall organization or biogenesisresponse to strresponse to stressresponse to extresponse to external stimulusresponse to bioresponse to biotic stimulus
peptidoglycan muralytic activityhydrolase activitytransferase activityion bindingprotein bindingpeptidoglycan muralytic activityhydrolase activitytransferase activityion bindingprotein bindingpeptidoglycan muralytic activityhydrolase activitytransferase activityion bindingprotein bindingpeptidoglycan muralytic activityhydrolase activitytransferase activityion bindingprotein bindingpeptidoglycan muralytic activityhydrolase activitytransferase activityion bindingprotein bindingpeptidoglycan muralytic activityhydrolase activitytransferase activityion bindingprotein bindingpeptidoglycan muralytic activityhydrolase activitytransferase activityion bindingprotein bindingpeptidoglycan muralytic activityhydrolase activitytransferase activityion bindingprotein bindingpeptidoglycan muralytic activityhydrolase activitytransferase activityion bindingprotein bindingpeptidoglycan muralytic activityhydrolase activitytransferase activityion bindingprotein bindingpeptidoglycan muralytic actipeptidoglycan muralytic activityhydrolase activityhydrolase activitytransferase activitytransferase activityion bindingion bindingprotein bindingprotein binding
extracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0005989 lactose biosynthetic process IEA
 biological_processGO:0016998 cell wall macromolecule catabolic process IBA
 biological_processGO:0050829 defense response to Gram-negative bacterium IBA
 biological_processGO:0050830 defense response to Gram-positive bacterium IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0003796 lysozyme activity IBA
 molecular_functionGO:0004461 lactose synthase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Lactose synthesis


Phenotype (from MGI, Zfin or HPO)
endocrine/exocrine gland phenotypeintegument phenotypeendocrine/exocrine gland phenotypeintegument phenotypeendocrine/exocrine gland phenotypeintegument phenotypeendocrine/exocrine gland phenotypeintegument phenotypeendocrine/exocrine gland phenotypeintegument phenotypeendocrine/exocrine gland phenotypeintegument phenotypeendocrine/exocrine gland phenotypeintegument phenotypeendocrine/exocrine gland phenotypeintegument phenotypeendocrine/exocrine gland phenotypeintegument phenotypeendocrine/exocrine gland phenotypeintegument phenotypeendocrine/exocrine gland phenotypeendocrine/exocrine gland phenotypeintegument phenotypeintegument phenotype
IDPhenotypeDefinition Genetic BG
 MP:0000627 abnormal mammary gland morphology "malformation of the milk-secreting gland that lies within the breast; usually rudimentary in males" [J:70183]
Show

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Igh-Jtm1(3H9-VDJ)Mwg/Igh-J+
Genetic Background: involves: C57BL/6 * NZB

Allelic Composition: Lalbatm1Jvt/Lalba+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lalbatm1Asty/Lalbatm1Asty
Genetic Background: involves: 129P2/OlaHsd

 MP:0004047 abnormal milk composition "anomaly in the protein or lipid content of milk" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Igh-Jtm1(3H9-VDJ)Mwg/Igh-J+
Genetic Background: involves: C57BL/6 * NZB

Allelic Composition: Lalbatm1Jvt/Lalba+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lalbatm1Asty/Lalbatm1Asty
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028413 P15535 / B4galt1 / Beta-1,4-galactosyltransferase 1 Lactose synthase A protein N-acetyllactosamine synthase Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase Beta-N-acetyl...  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr