ENSMUSG00000023070


Mus musculus

Features
Gene ID: ENSMUSG00000023070
  
Biological name :Rgn
  
Synonyms : Q64374 / Regucalcin / Rgn
  
Possible biological names infered from orthology : Q15493
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A1.3
Gene start: 20549787
Gene end: 20562089
  
Corresponding Affymetrix probe sets: 10598863 (MoGene1.0st)   1448852_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023832
NCBI entrez gene - 19733     See in Manteia.
MGI - MGI:108024
RefSeq - NM_009060
RefSeq - XM_006527572
RefSeq Peptide - NP_033086
swissprot - Q64374
Ensembl - ENSMUSG00000023070
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rgnENSDARG00000098645Danio rerio
 RGNENSGALG00000016724Gallus gallus
 RGNENSG00000130988Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005511  Senescence marker protein-30 (SMP-30)
 IPR008367  Regucalcin
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR013658  SMP-30/Gluconolactonase/LRE-like region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0010867 positive regulation of triglyceride biosynthetic process IEA
 biological_processGO:0010907 positive regulation of glucose metabolic process IEA
 biological_processGO:0010922 positive regulation of phosphatase activity IEA
 biological_processGO:0019853 L-ascorbic acid biosynthetic process IEA
 biological_processGO:0032515 negative regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0032781 positive regulation of ATPase activity IEA
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045019 negative regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045723 positive regulation of fatty acid biosynthetic process IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0050848 regulation of calcium-mediated signaling IEA
 biological_processGO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity IEA
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:1901318 negative regulation of flagellated sperm motility IEA
 biological_processGO:1901671 positive regulation of superoxide dismutase activity IEA
 biological_processGO:1901896 positive regulation of calcium-transporting ATPase activity IEA
 biological_processGO:1902679 negative regulation of RNA biosynthetic process IEA
 biological_processGO:1903011 negative regulation of bone development IEA
 biological_processGO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process IEA
 biological_processGO:1903611 negative regulation of calcium-dependent ATPase activity IEA
 biological_processGO:1903625 negative regulation of DNA catabolic process IEA
 biological_processGO:1903629 positive regulation of dUTP diphosphatase activity IEA
 biological_processGO:1903634 negative regulation of leucine-tRNA ligase activity IEA
 biological_processGO:2000279 negative regulation of DNA biosynthetic process IEA
 cellular_componentGO:0005576 extracellular region IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004341 gluconolactonase activity ISO
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030234 enzyme regulator activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000061 fragile skeleton "easily damaged or broken bones" [J:14208]
Show

Allelic Composition: Trp63tm1Cmis/Trp63+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Trp63tm1Cmis/Trp63+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: Arid1am1Mag/Arid1am1Mag
Genetic Background: involves: 129 * CD-1

 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
Show

Allelic Composition: Trp63tm1Cmis/Trp63+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Trp63tm1Cmis/Trp63+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001244 thin dermal layer "reduced thickness of the dermis" [J:65030]
Show

Allelic Composition: Trp63tm1Cmis/Trp63+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Trp63tm1Cmis/Trp63+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Trp63tm1Cmis/Trp63+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Trp63tm1Cmis/Trp63+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
Show

Allelic Composition: Trp63tm1Cmis/Trp63+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp63tm1Cmis/Trp63+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Trp63tm1Cmis/Trp63+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp63tm1Cmis/Trp63+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp63tm1Cmis/Trp63+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Arid1am1Mag/Arid1am1Mag
Genetic Background: involves: 129 * CD-1

 MP:0003116 rickets "overproduction and deficient calcification of osteoid tissue due to vitamin D deficiency; can lead to skeletal deformities, growth defects, hypocalcemia, and sometimes tetany; skeletal fractures occur frequently" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp63tm1Cmis/Trp63+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Trp63tm1Cmis/Trp63+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ikzf1plstc/Ikzf1+
Genetic Background: C57BL/6JSfdAnu-Ikzf1plstc

 MP:0004777 abnormal phospholipid level "anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp63tm1Cmis/Trp63+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
Show

Allelic Composition: Trp63tm1Cmis/Trp63+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Trp63tm1Cmis/Trp63+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trp63tm1Cmis/Trp63+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp63tm1Cmis/Trp63+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008412 increased cellular sensitivity to oxidative stress "greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp63tm1Cmis/Trp63+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp63tm1Cmis/Trp63+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp63tm1Cmis/Trp63+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009820 abnormal liver vasculature morphology "any structural anomaly of the blood vessel network of the bile-secreting exocrine gland" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp63tm1Cmis/Trp63+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010027 increased liver cholesterol level "greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp63tm1Cmis/Trp63+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010252 anterior subcapsular cataracts "a lens opacity localized beneath the anterior lens capsule" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
Show

Allelic Composition: Ikzf1plstc/Ikzf1+
Genetic Background: C57BL/6JSfdAnu-Ikzf1plstc

Allelic Composition: Rgntm1Aish/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010911 abnormal pulmonary acinus morphology "any structural anomaly of the part of the airway consisting of a respiratory bronchiole and all of its branches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Trp63tm1Cmis/Trp63+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011229 abnormal vitamin C level "any anomaly in the concentration of L-ascorbic acid (vitamin C), which is a common co-factor and has anti-oxidant activities in many species" [GO:0019852]
Show

Allelic Composition: Ikzf1plstc/Ikzf1+
Genetic Background: C57BL/6JSfdAnu-Ikzf1plstc

Allelic Composition: Rgntm1Aish/Y
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Rgntm1Aish/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Rgntm1Aish/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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