MP:0000061 | fragile skeleton | "easily damaged or broken bones" [J:14208] |
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Allelic Composition: Trp63tm1Cmis/Trp63+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0000063 | reduced bone density | "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
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Allelic Composition: Trp63tm1Cmis/Trp63+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0000414 | alopecia | "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796] |
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Allelic Composition: Arid1am1Mag/Arid1am1Mag Genetic Background: involves: 129 * CD-1
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MP:0000427 | abnormal hair cycle | "aberrant growth or asynchronous timing of the hair growth " [J:65302] |
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Allelic Composition: Trp63tm1Cmis/Trp63+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0000607 | abnormal hepatocyte morphology | "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Trp63tm1Cmis/Trp63+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0001244 | thin dermal layer | "reduced thickness of the dermis" [J:65030] |
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Allelic Composition: Trp63tm1Cmis/Trp63+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Trp63tm1Cmis/Trp63+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
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Allelic Composition: Trp63tm1Cmis/Trp63+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0001406 | abnormal gait | "unusual or distinctive way of walking" [J:65038] |
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Allelic Composition: Trp63tm1Cmis/Trp63+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0001958 | emphysema | "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629] |
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Allelic Composition: Trp63tm1Cmis/Trp63+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Trp63tm1Cmis/Trp63+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0002152 | abnormal brain morphology | "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk] |
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Allelic Composition: Trp63tm1Cmis/Trp63+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0002628 | fatty liver | "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Trp63tm1Cmis/Trp63+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0002655 | abnormal keratinocyte morphology | "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Trp63tm1Cmis/Trp63+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0002857 | cochlear ganglion degeneration | "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Arid1am1Mag/Arid1am1Mag Genetic Background: involves: 129 * CD-1
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MP:0003116 | rickets | "overproduction and deficient calcification of osteoid tissue due to vitamin D deficiency; can lead to skeletal deformities, growth defects, hypocalcemia, and sometimes tetany; skeletal fractures occur frequently" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Trp63tm1Cmis/Trp63+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0003674 | oxidative stress | "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Trp63tm1Cmis/Trp63+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0003887 | increased hepatocyte apoptosis | "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Ikzf1plstc/Ikzf1+ Genetic Background: C57BL/6JSfdAnu-Ikzf1plstc
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MP:0004777 | abnormal phospholipid level | "anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Trp63tm1Cmis/Trp63+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0005311 | abnormal circulating amino acid level | "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263] |
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Allelic Composition: Trp63tm1Cmis/Trp63+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0005332 | abnormal amino acid level | "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Trp63tm1Cmis/Trp63+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0005459 | decreased percent body fat | "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Trp63tm1Cmis/Trp63+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0005584 | abnormal enzyme/coenzyme activity | "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Trp63tm1Cmis/Trp63+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0008412 | increased cellular sensitivity to oxidative stress | "greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Trp63tm1Cmis/Trp63+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0009355 | increased liver triglyceride level | "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Trp63tm1Cmis/Trp63+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0009763 | increased sensitivity to induced morbidity/mortality | "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Trp63tm1Cmis/Trp63+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0009820 | abnormal liver vasculature morphology | "any structural anomaly of the blood vessel network of the bile-secreting exocrine gland" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Trp63tm1Cmis/Trp63+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0010027 | increased liver cholesterol level | "greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Trp63tm1Cmis/Trp63+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0010252 | anterior subcapsular cataracts | "a lens opacity localized beneath the anterior lens capsule" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"] |
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Allelic Composition: Ikzf1plstc/Ikzf1+ Genetic Background: C57BL/6JSfdAnu-Ikzf1plstc
Allelic Composition: Rgntm1Aish/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0010911 | abnormal pulmonary acinus morphology | "any structural anomaly of the part of the airway consisting of a respiratory bronchiole and all of its branches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Trp63tm1Cmis/Trp63+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0011229 | abnormal vitamin C level | "any anomaly in the concentration of L-ascorbic acid (vitamin C), which is a common co-factor and has anti-oxidant activities in many species" [GO:0019852] |
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Allelic Composition: Ikzf1plstc/Ikzf1+ Genetic Background: C57BL/6JSfdAnu-Ikzf1plstc
Allelic Composition: Rgntm1Aish/Y Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Rgntm1Aish/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0011967 | increased or absent threshold for auditory brainstem response | "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith] |
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Allelic Composition: Rgntm1Aish/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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