ENSMUSG00000023861


Mus musculus

Features
Gene ID: ENSMUSG00000023861
  
Biological name :Mpc1
  
Synonyms : Mitochondrial pyruvate carrier 1 / Mpc1 / P63030
  
Possible biological names infered from orthology : Q9Y5U8
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A1
Gene start: 8282904
Gene end: 8297661
  
Corresponding Affymetrix probe sets: 10402648 (MoGene1.0st)   10441642 (MoGene1.0st)   1453651_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116307
Ensembl peptide - ENSMUSP00000122214
Ensembl peptide - ENSMUSP00000119901
Ensembl peptide - ENSMUSP00000119443
Ensembl peptide - ENSMUSP00000118386
Ensembl peptide - ENSMUSP00000045654
NCBI entrez gene - 55951     See in Manteia.
MGI - MGI:1915240
RefSeq - XM_011246219
RefSeq - NM_018819
RefSeq Peptide - NP_061289
swissprot - D3Z786
swissprot - E9Q0V4
swissprot - D3YWY6
swissprot - P63030
swissprot - Q3UX28
swissprot - D3Z5S0
Ensembl - ENSMUSG00000023861
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mpc1ENSDARG00000093448Danio rerio
 MPC1ENSGALG00000011483Gallus gallus
 MPC1ENSG00000060762Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005336  Mitochondrial pyruvate carrier


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006850 mitochondrial pyruvate transmembrane transport IGI
 biological_processGO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate IMP
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031305 integral component of mitochondrial inner membrane IBA
 molecular_functionGO:0050833 pyruvate transmembrane transporter activity IGI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Zeb1tm1.2Mpst/Zeb1tm1.2Mpst
Genetic Background: involves: C57BL/6 * CBA

 MP:0002575 increased circulating ketone body level "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]
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Allelic Composition: Mpc1tm1c(EUCOMM)Wtsi/Mpc1tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mpc1tm1c(EUCOMM)Wtsi/Mpc1tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Mpc1tm1c(EUCOMM)Wtsi/Mpc1tm1c(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Mpc1tm1c(EUCOMM)Wtsi/Mpc1tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mpc1tm1c(EUCOMM)Wtsi/Mpc1tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mpc1tm1c(EUCOMM)Wtsi/Mpc1tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA

Allelic Composition: Mpc1tm1c(EUCOMM)Wtsi/Mpc1tm1c(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mpc1tm1c(EUCOMM)Wtsi/Mpc1tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mpc1tm1c(EUCOMM)Wtsi/Mpc1tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Mpc1tm1c(EUCOMM)Wtsi/Mpc1tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mpc1tm1c(EUCOMM)Wtsi/Mpc1tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA

 MP:0013405 increased circulating lactate level "greater amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase" [MPD:Molly]
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Allelic Composition: Mpc1tm1c(EUCOMM)Wtsi/Mpc1tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA

 MP:0014171 increased fatty acid oxidation "increased rate or incidence of the process of removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen" [GO:0019395]
Show

Allelic Composition: Mpc1tm1c(EUCOMM)Wtsi/Mpc1tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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