ENSMUSG00000023913


Mus musculus

Features
Gene ID: ENSMUSG00000023913
  
Biological name :Pla2g7
  
Synonyms : Pla2g7 / Platelet-activating factor acetylhydrolase / Q60963
  
Possible biological names infered from orthology : phospholipase A2 group VII / Q13093
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B3
Gene start: 43568098
Gene end: 43612201
  
Corresponding Affymetrix probe sets: 10445293 (MoGene1.0st)   1430700_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024706
Ensembl peptide - ENSMUSP00000132027
Ensembl peptide - ENSMUSP00000131898
Ensembl peptide - ENSMUSP00000130404
NCBI entrez gene - 27226     See in Manteia.
MGI - MGI:1351327
RefSeq - XM_006524365
RefSeq - XM_006524367
RefSeq - XM_006524366
RefSeq - NM_013737
RefSeq Peptide - NP_038765
swissprot - Q60963
swissprot - E9Q6J0
swissprot - E9Q330
swissprot - E9Q4T5
Ensembl - ENSMUSG00000023913
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pla2g7ENSDARG00000003584Danio rerio
 PLA2G7ENSGALG00000016713Gallus gallus
 PLA2G7ENSG00000146070Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pafah2 / Q8VDG7 / Platelet-activating factor acetylhydrolase 2, cytoplasmic / Q99487* / platelet activating factor acetylhydrolase 2*ENSMUSG0000003736635


Protein motifs (from Interpro)
Interpro ID Name
 IPR005065  Platelet-activating factor acetylhydrolase-like
 IPR016715  Platelet-activating factor acetylhydrolase, eucaryote
 IPR029058  Alpha/Beta hydrolase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0034374 low-density lipoprotein particle remodeling IEA
 biological_processGO:0034440 lipid oxidation IEA
 biological_processGO:0034441 plasma lipoprotein particle oxidation IEA
 biological_processGO:0046469 platelet activating factor metabolic process IEA
 biological_processGO:0090026 positive regulation of monocyte chemotaxis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0034362 low-density lipoprotein particle IEA
 molecular_functionGO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity IEA
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0047499 calcium-independent phospholipase A2 activity IEA


Pathways (from Reactome)
Pathway description
Synthesis, secretion, and deacylation of Ghrelin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Genetic Background: involves: 129S2/SvPas * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000064177 Ghrl / Q9EQX0 / Appetite-regulating hormone Ghrelin Obestatin / Q9UBU3* / ghrelin and obestatin prepropeptide*  / reaction






 

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