ENSMUSG00000024063


Mus musculus

Features
Gene ID: ENSMUSG00000024063
  
Biological name :Lbh
  
Synonyms : Lbh / Protein LBH / Q9CX60
  
Possible biological names infered from orthology : limb bud and heart development / Q53QV2
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: E1.3
Gene start: 72918305
Gene end: 72941942
  
Corresponding Affymetrix probe sets: 10446763 (MoGene1.0st)   1425208_at (Mouse Genome 430 2.0 Array)   1429088_at (Mouse Genome 430 2.0 Array)   1451629_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024857
Ensembl peptide - ENSMUSP00000123062
NCBI entrez gene - 77889     See in Manteia.
MGI - MGI:1925139
RefSeq - NM_029999
RefSeq Peptide - NP_084275
swissprot - F6UVG6
swissprot - Q9CX60
Ensembl - ENSMUSG00000024063
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LT631684.2ENSDARG00000111701Danio rerio
 LBHENSGALG00000009052Gallus gallus
 LBHENSG00000213626Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR013294  Protein LBH


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0030879 mammary gland development IMP
 biological_processGO:0033147 negative regulation of intracellular estrogen receptor signaling pathway IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0060644 mammary gland epithelial cell differentiation IMP
 biological_processGO:1904674 positive regulation of somatic stem cell population maintenance IMP
 biological_processGO:1904677 positive regulation of somatic stem cell division IMP
 biological_processGO:2000103 positive regulation of mammary stem cell proliferation IMP
 biological_processGO:2000737 negative regulation of stem cell differentiation IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pax6Aey80/Pax6+
Genetic Background: C3HeB/FeJ-Pax6Aey80

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax6Aey80/Pax6+
Genetic Background: C3HeB/FeJ-Pax6Aey80

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax6Aey80/Pax6+
Genetic Background: C3HeB/FeJ-Pax6Aey80

 MP:0003344 mammary gland hypoplasia "decreased size of mammary gland due to decreased cell number" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Pax6Aey80/Pax6+
Genetic Background: C3HeB/FeJ-Pax6Aey80

 MP:0006270 abnormal mammary gland growth during lactation "anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax6Aey80/Pax6+
Genetic Background: C3HeB/FeJ-Pax6Aey80

 MP:0006271 abnormal involution of the mammary gland "anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax6Aey80/Pax6+
Genetic Background: C3HeB/FeJ-Pax6Aey80

 MP:0009506 abnormal mammary gland alveolus morphology "any structural anomaly of the sac-like structure of the mammary gland that secretes milk after pregnancy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax6Aey80/Pax6+
Genetic Background: C3HeB/FeJ-Pax6Aey80

 MP:0012075 impaired mammary gland growth during pregnancy "defect in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation in preparation for lactation" [MGI:llw2]
Show

Allelic Composition: Pax6Aey80/Pax6+
Genetic Background: C3HeB/FeJ-Pax6Aey80

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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