ENSMUSG00000024381


Mus musculus

Features
Gene ID: ENSMUSG00000024381
  
Biological name :Bin1
  
Synonyms : Bin1 / Myc box-dependent-interacting protein 1 / O08539
  
Possible biological names infered from orthology : bridging integrator 1 / O00499
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: B1
Gene start: 32377217
Gene end: 32435736
  
Corresponding Affymetrix probe sets: 10454580 (MoGene1.0st)   1423618_at (Mouse Genome 430 2.0 Array)   1425532_a_at (Mouse Genome 430 2.0 Array)   1444120_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025239
Ensembl peptide - ENSMUSP00000089590
NCBI entrez gene - 30948     See in Manteia.
MGI - MGI:108092
RefSeq - XM_017317917
RefSeq - NM_001083334
RefSeq - NM_009668
RefSeq - XM_006525993
RefSeq - XM_006525994
RefSeq - XM_006525995
RefSeq - XM_017317916
RefSeq - XM_006525978
RefSeq - XM_006525979
RefSeq - XM_006525980
RefSeq - XM_006525981
RefSeq - XM_006525982
RefSeq - XM_006525983
RefSeq - XM_006525984
RefSeq - XM_006525985
RefSeq - XM_006525986
RefSeq - XM_006525987
RefSeq - XM_006525988
RefSeq - XM_006525989
RefSeq - XM_006525990
RefSeq - XM_006525991
RefSeq - XM_006525992
RefSeq Peptide - NP_033798
RefSeq Peptide - NP_001076803
swissprot - O08539
swissprot - Q6P1B9
Ensembl - ENSMUSG00000024381
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bin1aENSDARG00000042114Danio rerio
 bin1bENSDARG00000058820Danio rerio
 BIN1ENSGALG00000011541Gallus gallus
 BIN1ENSG00000136717Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Amph / Q7TQF7 / Amphiphysin / P49418*ENSMUSG0000002131447
Bin2 / bridging integrator 2ENSMUSG0000009811231


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR003005  Amphiphysin
 IPR003017  Amphiphysin, isoform 1
 IPR003023  Amphiphysin 2
 IPR004148  BAR domain
 IPR027267  AH/BAR domain superfamily
 IPR035471  Amphiphysin 2, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006997 nucleus organization IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008333 endosome to lysosome transport IEA
 biological_processGO:0030100 regulation of endocytosis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0042692 muscle cell differentiation IMP
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045664 regulation of neuron differentiation IEA
 biological_processGO:0048711 positive regulation of astrocyte differentiation IEA
 biological_processGO:0051647 nucleus localization IMP
 biological_processGO:0060988 lipid tube assembly IEA
 biological_processGO:0071156 regulation of cell cycle arrest IEA
 biological_processGO:1902430 negative regulation of amyloid-beta formation IMP
 biological_processGO:1902960 negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005635 nuclear envelope IDA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030018 Z disc ISS
 cellular_componentGO:0030315 T-tubule ISS
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0031674 I band ISS
 cellular_componentGO:0033268 node of Ranvier ISS
 cellular_componentGO:0043194 axon initial segment ISS
 cellular_componentGO:0060987 lipid tube IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0048156 tau protein binding IPI
 molecular_functionGO:0051015 actin filament binding IEA
 molecular_functionGO:0051087 chaperone binding IEA
 molecular_functionGO:0070063 RNA polymerase binding IEA


Pathways (from Reactome)
Pathway description
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crxtm1Clc/Crx+
Genetic Background: involves: 129S6/SvEvTac

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
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Allelic Composition: Crxtm1Clc/Crx+
Genetic Background: involves: 129S6/SvEvTac

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
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Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

 MP:0002952 ventricular cardiomyopathy "diseases of the ventricles of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

 MP:0004093 diffuse Z lines "widely spread cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

 MP:0004135 abnormal mammary gland embryonic development "aberration in the differentiation of the mammary gland during early embryogenesis" [smb:Susan M Bello, Mouse Genome Informatics Curator, llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Rpl38Ts/Rpl38Ts
Genetic Background: BALB/c-Rpl38Ts

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rpl38Ts/Rpl38Ts
Genetic Background: BALB/c-Rpl38Ts

Allelic Composition: Bin1tm2Gcp/Bin1+,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Crxtm1Clc/Crx+
Genetic Background: involves: 129S6/SvEvTac

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Crxtm1Clc/Crx+
Genetic Background: involves: 129S6/SvEvTac

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Crxtm1Clc/Crx+
Genetic Background: involves: 129S6/SvEvTac

 MP:0006271 abnormal involution of the mammary gland "anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Rpl38Ts/Rpl38Ts
Genetic Background: BALB/c-Rpl38Ts

 MP:0009360 endometrium inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the endometrium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Rpl38Ts/Rpl38Ts
Genetic Background: BALB/c-Rpl38Ts

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rpl38Ts/Rpl38Ts
Genetic Background: BALB/c-Rpl38Ts

Allelic Composition: Bin1tm2Gcp/Bin1+,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

 MP:0012411 increased granulosa cell tumor incidence "greater than the expected number of neoplasms derived from somatic cells of the sex cord in the ovary a given population in a given time period" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Rpl38Ts/Rpl38Ts
Genetic Background: BALB/c-Rpl38Ts

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Crxtm1Clc/Crx+
Genetic Background: involves: 129S6/SvEvTac

 MP:0030566 abnormal A band morphology "any structural anomaly of the dark-staining region of a sarcomere that is situated between two I bands and marked by partial overlapping of thin (actin) and thick (myosin) filaments; an A band is anisotropic to polarized light and contains the entire length of a single thick filament; its center is traversed by the paler H zone, which in turn contains the M line" [GO:0031672, https://en.wikipedia.org/wiki/Sarcomere, https://medical-dictionary.thefreedictionary.com/A+band]
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Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021314 Amph / Q7TQF7 / Amphiphysin / P49418*  / complex






 

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