ENSMUSG00000024503


Mus musculus

Features
Gene ID: ENSMUSG00000024503
  
Biological name :Spink1
  
Synonyms : P09036 / serine peptidase inhibitor, Kazal type 1 / Spink1
  
Possible biological names infered from orthology : P00995
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: B3
Gene start: 43728069
Gene end: 43737237
  
Corresponding Affymetrix probe sets: 10458704 (MoGene1.0st)   1415938_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025381
NCBI entrez gene - 20730     See in Manteia.
MGI - MGI:106202
RefSeq - NM_009258
RefSeq Peptide - NP_033284
swissprot - P09036
Ensembl - ENSMUSG00000024503
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-203a12.9ENSDARG00000104721Danio rerio
 P00995ENSG00000164266Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001239  Proteinase inhibitor I1, Kazal-type, metazoa
 IPR002350  Kazal domain
 IPR036058  Kazal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010466 negative regulation of peptidase activity IDA
 biological_processGO:0010751 negative regulation of nitric oxide mediated signal transduction IDA
 biological_processGO:0048240 sperm capacitation IDA
 biological_processGO:0050732 negative regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0060046 regulation of acrosome reaction IDA
 biological_processGO:0090281 negative regulation of calcium ion import IDA
 biological_processGO:1900004 negative regulation of serine-type endopeptidase activity IMP
 biological_processGO:2001256 regulation of store-operated calcium entry IDA
 cellular_componentGO:0001669 acrosomal vesicle IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IMP
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0001199 thin skin "reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0003271 abnormal duodenum morphology "malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0005520 decreased pancreas regeneration "less than the normal ability of the pancreas to regenerate healthy tissue following injury" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0009146 abnormal pancreatic acinar cell morphology "any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

Allelic Composition: Spink1tm2Kymm/Spink1tm2Kymm
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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