ENSMUSG00000024593


Mus musculus

Features
Gene ID: ENSMUSG00000024593
  
Biological name :Megf10
  
Synonyms : Megf10 / Multiple epidermal growth factor-like domains protein 10 / Q6DIB5
  
Possible biological names infered from orthology : multiple EGF like domains 10 / Q96KG7
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: D3
Gene start: 57133090
Gene end: 57297467
  
Corresponding Affymetrix probe sets: 10455826 (MoGene1.0st)   1429841_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116814
Ensembl peptide - ENSMUSP00000075174
NCBI entrez gene - 70417     See in Manteia.
MGI - MGI:2685177
RefSeq - NM_001001979
RefSeq Peptide - NP_001001979
swissprot - A0A140T8S0
swissprot - Q6DIB5
Ensembl - ENSMUSG00000024593
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 megf10ENSDARG00000017229Danio rerio
 MEGF10ENSGALG00000014699Gallus gallus
 MEGF10ENSG00000145794Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Megf11 / Q80T91 / Multiple epidermal growth factor-like domains protein 11 / A6BM72* / multiple EGF like domains 11*ENSMUSG0000003646657
Pear1 / Q8VIK5 / platelet endothelial aggregation receptor 1 / Q5VY43*ENSMUSG0000002807342
Megf6 / multiple EGF like domains 6 / O75095*ENSMUSG0000005775131
Q5ND28 / Scarf1 / Scavenger receptor class F member 1 / Q14162*ENSMUSG0000003818818
P59222 / Scarf2 / Scavenger receptor class F member 2 / Q96GP6*ENSMUSG0000001201717
Egfem1 / Q8C088 / EGF-like and EMI domain-containing protein 1 ENSMUSG000000636008


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR002049  Laminin EGF domain
 IPR011489  EMI domain
 IPR013032  EGF-like, conserved site
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0014719 skeletal muscle satellite cell activation IMP
 biological_processGO:0014816 skeletal muscle satellite cell differentiation IMP
 biological_processGO:0014841 skeletal muscle satellite cell proliferation IDA
 biological_processGO:0033002 muscle cell proliferation IEA
 biological_processGO:0034109 homotypic cell-cell adhesion IEA
 biological_processGO:0043652 engulfment of apoptotic cell IMP
 biological_processGO:0043654 recognition of apoptotic cell IMP
 biological_processGO:0048641 regulation of skeletal muscle tissue development IEA
 biological_processGO:0051147 regulation of muscle cell differentiation IEA
 biological_processGO:0051451 myoblast migration IEA
 biological_processGO:0055001 muscle cell development IEA
 biological_processGO:1902742 apoptotic process involved in development IMP
 cellular_componentGO:0001891 phagocytic cup ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0001849 complement component C1q binding IEA
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0005112 Notch binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gfertm1(KOMP)Mbp/Gfertm1(KOMP)Mbp
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Megf10tm1(KOMP)Vlcg/Megf10+
Genetic Background: C57BL/6N-Megf10tm1(KOMP)Vlcg

 MP:0005240 abnormal amacrine cell morphology "anomalous structure of the interneurons of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp
Genetic Background: involves: 129S1/Sv

Allelic Composition: Megf10tm1a(KOMP)Jrs/Megf10tm1a(KOMP)Jrs
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Megf10tm1a(KOMP)Jrs/Megf10+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006068 abnormal horizontal cell morphology "anomalous structure of the laterally interconnecting neurons in the outer plexiform layer" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Megf10tm1a(KOMP)Jrs/Megf10tm1a(KOMP)Jrs,Megf11tm1a(EUCOMM)Wtsi/Megf11tm1a(EUCOMM)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N

Allelic Composition: Megf10tm1a(KOMP)Jrs/Megf10tm1a(KOMP)Jrs
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008916 abnormal astrocyte physiology "any functional anomaly of one of the large neuroglia cells of nervous tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gfertm1(KOMP)Mbp/Gfertm1(KOMP)Mbp
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Megf10tm1(KOMP)Vlcg/Megf10+
Genetic Background: C57BL/6N-Megf10tm1(KOMP)Vlcg

 MP:0012261 increased hindbrain apoptosis "increase in the number of cells of the hindbrain undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Gfertm1(KOMP)Mbp/Gfertm1(KOMP)Mbp
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Megf10tm1(KOMP)Vlcg/Megf10+
Genetic Background: C57BL/6N-Megf10tm1(KOMP)Vlcg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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