ENSMUSG00000024764


Mus musculus

Features
Gene ID: ENSMUSG00000024764
  
Biological name :Naa40
  
Synonyms : Naa40 / N-alpha-acetyltransferase 40 / Q8VE10
  
Possible biological names infered from orthology : N(alpha)-acetyltransferase 40, NatD catalytic subunit / Q86UY6
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 7225668
Gene end: 7241222
  
Corresponding Affymetrix probe sets: 10465638 (MoGene1.0st)   1443625_at (Mouse Genome 430 2.0 Array)   1452120_at (Mouse Genome 430 2.0 Array)   1458576_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025675
NCBI entrez gene - 70999     See in Manteia.
MGI - MGI:1918249
RefSeq - NM_027643
RefSeq - XM_006527336
RefSeq Peptide - NP_081919
swissprot - Q8VE10
Ensembl - ENSMUSG00000024764
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 naa40ENSDARG00000024109Danio rerio
 naa40ENSDARG00000090570Danio rerio
 NAA40ENSG00000110583Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000182  GNAT domain
 IPR016181  Acyl-CoA N-acyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006474 N-terminal protein amino acid acetylation IEA
 biological_processGO:0006629 lipid metabolic process IMP
 biological_processGO:0043967 histone H4 acetylation IEA
 biological_processGO:0043968 histone H2A acetylation IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0008080 N-acetyltransferase activity IEA
 molecular_functionGO:0010485 H4 histone acetyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0043998 H2A histone acetyltransferase activity IEA
 molecular_functionGO:1990189 peptide-serine-N-acetyltransferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Naa40tm1Qwzh/Naa40tm1Qwzh,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Naa40tm1Qwzh

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Naa40tm1Qwzh/Naa40tm1Qwzh,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Naa40tm1Qwzh

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Gng3tm1.1Rbs/Gng3tm1.1Rbs,Gng7tm1Lex/Gng7tm1Lex
Genetic Background: B6.Cg-Gng7tm1Lex Gng3tm1.1Rbs

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Naa40tm1Qwzh/Naa40tm1Qwzh,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Naa40tm1Qwzh

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Naa40tm1Qwzh/Naa40tm1Qwzh,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Naa40tm1Qwzh

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Naa40tm1Qwzh/Naa40tm1Qwzh,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Naa40tm1Qwzh

 MP:0003976 decreased circulating VLDL triglyceride level "lower than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Naa40tm1Qwzh/Naa40tm1Qwzh,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Naa40tm1Qwzh

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Naa40tm1Qwzh/Naa40tm1Qwzh,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Naa40tm1Qwzh

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Naa40tm1Qwzh/Naa40tm1Qwzh,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Naa40tm1Qwzh

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Naa40tm1Qwzh/Naa40tm1Qwzh,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Naa40tm1Qwzh

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Naa40tm1Qwzh/Naa40tm1Qwzh,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Naa40tm1Qwzh

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Naa40tm1Qwzh/Naa40tm1Qwzh,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Naa40tm1Qwzh

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Naa40tm1Qwzh/Naa40tm1Qwzh,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Naa40tm1Qwzh

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Naa40tm1Qwzh/Naa40tm1Qwzh,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Naa40tm1Qwzh

 MP:0010360 decreased liver free fatty acids level "reduced liver concentration of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Naa40tm1Qwzh/Naa40tm1Qwzh,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Naa40tm1Qwzh

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Naa40tm1Qwzh/Naa40tm1Qwzh,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Naa40tm1Qwzh

 MP:0014171 increased fatty acid oxidation "increased rate or incidence of the process of removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen" [GO:0019395]
Show

Allelic Composition: Naa40tm1Qwzh/Naa40tm1Qwzh,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Naa40tm1Qwzh

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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