ENSMUSG00000024793


Mus musculus

Features
Gene ID: ENSMUSG00000024793
  
Biological name :Tnfrsf25
  
Synonyms : Tnfrsf25 / tumor necrosis factor receptor superfamily, member 25
  
Possible biological names infered from orthology : Q93038 / TNF receptor superfamily member 25
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: E2
Gene start: 152115934
Gene end: 152120119
  
Corresponding Affymetrix probe sets: 10510668 (MoGene1.0st)   1422231_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025706
Ensembl peptide - ENSMUSP00000047823
NCBI entrez gene - 85030     See in Manteia.
MGI - MGI:1934667
RefSeq - XM_011250363
RefSeq - NM_001291010
RefSeq - NM_033042
RefSeq - XM_006539318
RefSeq - XM_006539319
RefSeq - XM_011250362
RefSeq Peptide - NP_001277939
RefSeq Peptide - NP_149031
swissprot - B1AWN9
swissprot - Q8VD70
Ensembl - ENSMUSG00000024793
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-112c15.8ENSDARG00000089868Danio rerio
 ENSGALG00000026499Gallus gallus
 Q93038ENSG00000215788Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P25118 / Tnfrsf1a / tumor necrosis factor receptor superfamily, member 1a / P19438* / TNF receptor superfamily member 1A*ENSMUSG0000003034123


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR011029  Death-like domain superfamily
 IPR022329  Tumour necrosis factor receptor 25
 IPR034050  Tumor necrosis factor receptor 25, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0097190 apoptotic signaling pathway IBA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005031 tumor necrosis factor-activated receptor activity IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
TNFs bind their physiological receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000714 increased thymocyte number "greater than expected number of precursors to T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tg(TcraH-Y,TcrbH-Y)71Vbo/0,Tnfrsf25tm1Mjo/Tnfrsf25tm1Mjo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tnfrsf25tm1Mjo/Tnfrsf25tm1Mjo
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0004918 abnormal negative T cell selection "any anomaly in the process of elimination of immature T cells which react strongly with self-antigens" [GO:0043383]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tg(TcraH-Y,TcrbH-Y)71Vbo/0,Tnfrsf25tm1Mjo/Tnfrsf25tm1Mjo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0006414 decreased T cell apoptosis "decrease in the number of T cells undergoing programmed cell death" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Ripk3tm2Vmd/Ripk3tm2Vmd,Tnfrsf25tm1Lex/Tnfrsf25tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000050395 Tnfsf15 / tumor necrosis factor (ligand) superfamily, member 15 / O95150* / TNF superfamily member 15*  / complex / reaction






 

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