ENSMUSG00000024873


Mus musculus

Features
Gene ID: ENSMUSG00000024873
  
Biological name :Cnih2
  
Synonyms : 2 / Cnih2 / O35089
  
Possible biological names infered from orthology : cornichon family AMPA receptor auxiliary protein 2 / Q6PI25
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 5092871
Gene end: 5098418
  
Corresponding Affymetrix probe sets: 10464917 (MoGene1.0st)   1417524_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025805
NCBI entrez gene - 12794     See in Manteia.
MGI - MGI:1277225
RefSeq - NM_009920
RefSeq - NM_001302333
RefSeq Peptide - NP_001289262
RefSeq Peptide - NP_034050
swissprot - O35089
swissprot - Q3SYI8
Ensembl - ENSMUSG00000024873
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cnih2ENSDARG00000043662Danio rerio
 CNIH2ENSG00000174871Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
3 / Cnih3 / Q6ZWS4 / Q8TBE1* / cornichon family AMPA receptor auxiliary protein 3*ENSMUSG0000002651480
1 / Cnih1 / O35372 / O95406* / cornichon family AMPA receptor auxiliary protein 1*ENSMUSG0000001575965
4 / Cnih4 / Q9CX13 / Q9P003* / cornichon family AMPA receptor auxiliary protein 4*ENSMUSG0000006216926


Protein motifs (from Interpro)
Interpro ID Name
 IPR003377  Cornichon
 IPR033466  Cornichon, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0035249 synaptic transmission, glutamatergic IEA
 biological_processGO:0042391 regulation of membrane potential IEA
 biological_processGO:0051668 localization within membrane IEA
 biological_processGO:1902684 negative regulation of receptor localization to synapse IEA
 biological_processGO:1903743 negative regulation of anterograde synaptic vesicle transport IEA
 biological_processGO:2000310 regulation of NMDA receptor activity IEA
 biological_processGO:2000311 regulation of AMPA receptor activity IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0032281 AMPA glutamate receptor complex IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043198 dendritic shaft IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane ISS
 molecular_functionGO:0016247 channel regulator activity ISO


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
Cargo concentration in the ER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Cnih2tm1.1Ran/Cnih2tm1.1Ran,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Tardbptm1.1Ckjs/Tardbptm1.2Cjks
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002885 abnormal AMPA-mediated synaptic currents "change in the measured amplitude or duration of response to stimulation of AMPA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Tardbptm1.1Ckjs/Tardbptm1.2Cjks
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Tardbptm1.1Ckjs/Tardbptm1.2Cjks
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Cnih2tm1.1Ran/Cnih2tm1.1Ran,Cnih3tm1.1Ran/Cnih3tm1.1Ran
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0011003 reduced AMPA-mediated synaptic currents "reduction in the measured amplitude, current density or duration of response to stimulation of AMPA receptors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Tardbptm1.1Ckjs/Tardbptm1.2Cjks
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Cnih2tm1.1Ran/Cnih2tm1.1Ran,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NTac

Allelic Composition: Cnih2tm1.1Ran/Cnih2tm1.1Ran,Cnih3tm1.1Ran/Cnih3tm1.1Ran
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020524 Gria1 / P23818 / Glutamate receptor 1 / P42261* / glutamate ionotropic receptor AMPA type subunit 1*  / complex / reaction






 

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