ENSMUSG00000024883


Mus musculus

Features
Gene ID: ENSMUSG00000024883
  
Biological name :Rin1
  
Synonyms : Q921Q7 / Ras and Rab interactor 1 / Rin1
  
Possible biological names infered from orthology : Q13671
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 5050481
Gene end: 5057071
  
Corresponding Affymetrix probe sets: 10460529 (MoGene1.0st)   1424507_at (Mouse Genome 430 2.0 Array)   1437460_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025818
Ensembl peptide - ENSMUSP00000152913
Ensembl peptide - ENSMUSP00000153574
Ensembl peptide - ENSMUSP00000153481
Ensembl peptide - ENSMUSP00000153351
Ensembl peptide - ENSMUSP00000153189
Ensembl peptide - ENSMUSP00000153118
NCBI entrez gene - 225870     See in Manteia.
MGI - MGI:2385695
RefSeq - XM_006531719
RefSeq - XM_006531711
RefSeq - XM_006531712
RefSeq - XM_006531713
RefSeq - XM_006531714
RefSeq - XM_006531715
RefSeq - XM_006531716
RefSeq - XM_006531717
RefSeq - XM_006531718
RefSeq - NM_145495
RefSeq - XM_006531709
RefSeq - XM_006531710
RefSeq Peptide - NP_663470
swissprot - A0A286YDL8
swissprot - A0A286YDC3
swissprot - A0A286YCR5
swissprot - A0A286YCC1
swissprot - A0A2C9F2A2
swissprot - A0A286YDV8
swissprot - Q921Q7
Ensembl - ENSMUSG00000024883
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rin1aENSDARG00000079095Danio rerio
 si:ch211-168d1.3ENSDARG00000070100Danio rerio
 RIN1ENSG00000174791Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rin2 / Q9D684 / Ras and Rab interactor 2 / Q8WYP3*ENSMUSG0000000176832
Rin3 / P59729 / Ras and Rab interactor 3 / Q8TB24*ENSMUSG0000004445628
Rinl / Q80UW3 / Mus musculus Ras and Rab interactor-like (Rinl), transcript variant 2, mRNA. / Q6ZS11* / Ras and Rab interactor like*ENSMUSG0000005173516


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR000980  SH2 domain
 IPR003123  VPS9 domain
 IPR035867  Ras and Rab interactor 1, SH2 domain
 IPR036860  SH2 domain superfamily
 IPR037191  VPS9 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007613 memory IMP
 biological_processGO:0008306 associative learning IMP
 biological_processGO:0031914 negative regulation of synaptic plasticity IMP
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017016 Ras GTPase binding IDA


Pathways (from Reactome)
Pathway description
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Pde4dtm2Mct/Pde4dtm2Mct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002805 abnormal conditioned taste aversion behavior "a defect in the ability of an animal to learn to avoid food sources that were previously associated with aversive internal stimuli or sickness such as a drug that induces sickness " [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Pde4dtm2Mct/Pde4dtm2Mct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
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Allelic Composition: Pde4dtm2Mct/Pde4dtm2Mct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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