ENSMUSG00000024907


Mus musculus

Features
Gene ID: ENSMUSG00000024907
  
Biological name :Gal
  
Synonyms : Gal / Galanin peptides Galanin Galanin message-associated peptide / P47212
  
Possible biological names infered from orthology : galanin and GMAP prepropeptide / P22466
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 3409919
Gene end: 3414472
  
Corresponding Affymetrix probe sets: 10464471 (MoGene1.0st)   1460668_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025842
NCBI entrez gene - 14419     See in Manteia.
MGI - MGI:95637
RefSeq - NM_010253
RefSeq Peptide - NP_034383
swissprot - P47212
swissprot - Q3V002
Ensembl - ENSMUSG00000024907
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 galnENSDARG00000091377Danio rerio
 GALENSGALG00000007047Gallus gallus
 GALENSG00000069482Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008174  Galanin
 IPR008175  Galanin precursor
 IPR013068  Galanin message associated peptide (GMAP)


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007218 neuropeptide signaling pathway IMP
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0007631 feeding behavior IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010737 protein kinase A signaling IEA
 biological_processGO:0019933 cAMP-mediated signaling IEA
 biological_processGO:0031943 regulation of glucocorticoid metabolic process IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0035902 response to immobilization stress IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050672 negative regulation of lymphocyte proliferation IEA
 biological_processGO:0051464 positive regulation of cortisol secretion IEA
 biological_processGO:0051795 positive regulation of timing of catagen IEA
 biological_processGO:1902608 positive regulation of large conductance calcium-activated potassium channel activity IEA
 biological_processGO:1902891 negative regulation of root hair elongation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0004966 galanin receptor activity IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005184 neuropeptide hormone activity IEA
 molecular_functionGO:0031763 galanin receptor binding IBA
 molecular_functionGO:0031764 type 1 galanin receptor binding IEA
 molecular_functionGO:0031765 type 2 galanin receptor binding IEA
 molecular_functionGO:0031766 type 3 galanin receptor binding IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myd88lkd/Myd88lkd
Genetic Background: C57BL/6-Myd88lkd

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Myd88lkd/Myd88lkd
Genetic Background: C57BL/6-Myd88lkd

 MP:0000966 reduced sensory neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Myd88lkd/Myd88lkd
Genetic Background: C57BL/6-Myd88lkd

 MP:0001021 small L4 ganglion "reduced size of L4 ganglion" [J:17792]
Show

Allelic Composition: Myd88lkd/Myd88lkd
Genetic Background: C57BL/6-Myd88lkd

 MP:0001024 small L5 ganglion "reduced size of L5 ganglion" [J:17792]
Show

Allelic Composition: Myd88lkd/Myd88lkd
Genetic Background: C57BL/6-Myd88lkd

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Myd88lkd/Myd88lkd
Genetic Background: C57BL/6-Myd88lkd

 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Myd88lkd/Myd88lkd
Genetic Background: C57BL/6-Myd88lkd

 MP:0001560 abnormal circulating insulin level "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myd88lkd/Myd88lkd
Genetic Background: C57BL/6-Myd88lkd

 MP:0001746 abnormal pituitary secretion "altered ability of the pituitary to release its products" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myd88lkd/Myd88lkd
Genetic Background: C57BL/6-Myd88lkd

Allelic Composition: Galtm1Wyn/Galtm1Wyn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
Show

Allelic Composition: Myd88lkd/Myd88lkd
Genetic Background: C57BL/6-Myd88lkd

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myd88lkd/Myd88lkd
Genetic Background: C57BL/6-Myd88lkd

 MP:0002163 abnormal gland morphology "abnormal development of any glandular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myd88lkd/Myd88lkd
Genetic Background: C57BL/6-Myd88lkd

 MP:0002164 abnormal gland physiology "altered glandular secretion not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myd88lkd/Myd88lkd
Genetic Background: C57BL/6-Myd88lkd

 MP:0002782 abnormal testicular secretion "malfunction of the production and/or release of hormones from testicular tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Galtm1Wyn/Galtm1Wyn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: Myd88lkd/Myd88lkd
Genetic Background: C57BL/6-Myd88lkd

 MP:0002997 enlarged seminal gland "increased size, compared to the norm, of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Galtm1Wyn/Galtm1Wyn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
Show

Allelic Composition: Myd88lkd/Myd88lkd
Genetic Background: C57BL/6-Myd88lkd

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Myd88lkd/Myd88lkd
Genetic Background: C57BL/6-Myd88lkd

 MP:0003368 decreased circulating glucocorticoid level "less than normal blood concentration of the corticosteroids regulating carbohydrate metabolism and exhibiting anti-inflammatory activity" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Galtm1Wyn/Galtm1Wyn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Galtm1Wyn/Galtm1Wyn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004858 abnormal nervous system regeneration "changes in the ability or inability of healthy nervous system tissue to regenerate following injury or disease" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Myd88lkd/Myd88lkd
Genetic Background: C57BL/6-Myd88lkd

 MP:0008235 increased susceptibility to neuronal excitotoxicity "greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myd88lkd/Myd88lkd
Genetic Background: C57BL/6-Myd88lkd

 MP:0008332 decreased lactotroph cell number "reduced number of an acidophilic cell of the anterior pituitary that produces prolactin" [CL:0000439, MESH:A06.407.747.608.812]
Show

Allelic Composition: Myd88lkd/Myd88lkd
Genetic Background: C57BL/6-Myd88lkd

 MP:0010249 lactation failure "mammary glands do not secrete milk after parturition" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myd88lkd/Myd88lkd
Genetic Background: C57BL/6-Myd88lkd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000114755 Galr3 / O88853 / Galanin receptor type 3 / O60755* / galanin receptor 3*  / complex / reaction
 ENSMUSG00000024553 Galr1 / P56479 / Galanin receptor type 1 / P47211* / galanin receptor 1*  / complex / reaction
 ENSMUSG00000020793 Galr2 / O88854 / Galanin receptor type 2 / O43603* / galanin receptor 2*  / complex / reaction






 

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