ENSMUSG00000025094


Mus musculus

Features
Gene ID: ENSMUSG00000025094
  
Biological name :Slc18a2
  
Synonyms : Q8BRU6 / Slc18a2 / Synaptic vesicular amine transporter
  
Possible biological names infered from orthology : Q05940 / solute carrier family 18 member A2
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: D3
Gene start: 59260878
Gene end: 59296012
  
Corresponding Affymetrix probe sets: 10464370 (MoGene1.0st)   1437079_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026084
NCBI entrez gene - 214084     See in Manteia.
MGI - MGI:106677
RefSeq - NM_172523
RefSeq Peptide - NP_766111
swissprot - Q8BRU6
Ensembl - ENSMUSG00000025094
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q05940ENSG00000165646Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8R090 / Slc18a1 / Chromaffin granule amine transporter / P54219* / solute carrier family 18 member A1*ENSMUSG0000003633062
Slc18a3 / solute carrier family 18 member A3 / Q16572*ENSMUSG0000010024136
D3Z5L6 / Slc18b1 / Mus musculus solute carrier family 18, subfamily B, member 1 (Slc18b1), transcript variant 2, mRNA. / Q6NT16* / solute carrier family 18 member B1*ENSMUSG0000003745518


Protein motifs (from Interpro)
Interpro ID Name
 IPR004734  Multidrug resistance protein
 IPR011701  Major facilitator superfamily
 IPR020846  Major facilitator superfamily domain
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001975 response to amphetamine IMP
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0006837 serotonin transport IEA
 biological_processGO:0006855 drug transmembrane transport IEA
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0009636 response to toxic substance IMP
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0015842 aminergic neurotransmitter loading into synaptic vesicle IBA
 biological_processGO:0015893 drug transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015222 serotonin transmembrane transporter activity IBA
 molecular_functionGO:0015238 drug transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Na+/Cl- dependent neurotransmitter transporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Chrm3tm1Mmt/Chrm3tm1Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Slc18a2tm2Kmo/Slc18a2tm2Kmo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Chrm3tm1Mmt/Chrm3tm1Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Mapkapk5tm1Pqs/Mapkapk5+,Tg(SV40-NRAS*G12D)1Sco/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
Show

Allelic Composition: Slc18a2tm1.1Bgir/Slc18a2tm1.1Bgir,Slc6a4tm1(cre)Xz/Slc6a4+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Slc18a2tm2Kmo/Slc18a2tm2Kmo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Slc18a2tm1Mca/Slc18a2tm1Mca
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Slc18a2tm1Mca/Slc18a2+
Genetic Background: B6.129X1-Slc18a2tm1Mca

Allelic Composition: Slc18a2tm1.1Bgir/Slc18a2tm1.1Bgir,Slc6a4tm1(cre)Xz/Slc6a4+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc18a2tm2Kmo/Slc18a2tm2Kmo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001408 stereotypic behavior "repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s wrong with my mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Slc18a2tm2Kmo/Slc18a2tm2Kmo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001413 abnormal response to new environment "altered investigative behavior from controls in reactions associated with placing an animal in a new location" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Mapkapk5tm1Pqs/Mapkapk5+,Tg(SV40-NRAS*G12D)1Sco/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001423 abnormal liquid preference "the desire to drink more or less fluids than average, or to drink unusual fluids" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc18a2tm1Mca/Slc18a2+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Slc18a2tm1Mca/Slc18a2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapkapk5tm1Pqs/Mapkapk5+,Tg(SV40-NRAS*G12D)1Sco/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc18a2tm1Mca/Slc18a2tm1Mca
Genetic Background: involves: 129X1/SvJ

 MP:0001905 abnormal dopamine level "greater or less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Slc18a2tm1Mca/Slc18a2tm1Mca
Genetic Background: involves: 129X1/SvJ

 MP:0002062 abnormal conditioning behavior "inability to change the frequency or form of a behavior as a result of the influence of the environment " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc18a2tm1Mca/Slc18a2+
Genetic Background: involves: 129X1/SvJ

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapkapk5tm1Pqs/Mapkapk5+,Tg(SV40-NRAS*G12D)1Sco/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf9tm1.2Fwan/Fgf9tm1.2Fwan
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002204 abnormal neurotransmitter physiology "aberrant function or production of endogenous signaling molecules secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Slc18a2tm1Mca/Slc18a2tm1Mca
Genetic Background: involves: 129X1/SvJ

 MP:0002572 abnormal emotion/affect behavior "altered response in tests for emotional related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapkapk5tm1Pqs/Mapkapk5+,Tg(SV40-NRAS*G12D)1Sco/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Slc18a2tm1.1Bgir/Slc18a2tm1.1Bgir,Slc6a4tm1(cre)Xz/Slc6a4+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc18a2tm1Mca/Slc18a2+
Genetic Background: B6.129X1-Slc18a2tm1Mca

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
Show

Allelic Composition: Slc18a2tm1Mca/Slc18a2+
Genetic Background: B6.129X1-Slc18a2tm1Mca

 MP:0003064 decreased coping response "reduced ability to respond productively to a stressful situation" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Slc18a2tm2Kmo/Slc18a2tm2Kmo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Slc18a2tm1Mca/Slc18a2+
Genetic Background: B6.129X1-Slc18a2tm1Mca

 MP:0003107 abnormal response to novelty "alteration in amount of exploration/investigation of a novel object, situation or environment" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Slc18a2tm2Kmo/Slc18a2tm2Kmo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc18a2tm2Kmo/Slc18a2tm2Kmo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003233 prolonged QT interval "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf9tm1.2Fwan/Fgf9tm1.2Fwan
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0003243 abnormal dopaminergic neuron morphology "malformation or absence of the neurons that utilize dopamine as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0003444 abnormal neurotransmitter uptake "aberration in the reabsorbtion of endogenous signaling molecules normally taken in by neurons that alter the behavior of neurons or effector cells" [J:95639, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc18a2tm1Mca/Slc18a2+
Genetic Background: involves: 129X1/SvJ

 MP:0003462 abnormal response to novel odor "altered investigative behavior from controls in reactions associated with exposing an animal to a novel odor" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Slc18a2tm2Kmo/Slc18a2tm2Kmo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003546 decreased alcohol consumption "less than normal consumption of alcohol" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Slc18a2tm1Mca/Slc18a2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Slc18a2tm2Kmo/Slc18a2tm2Kmo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003867 increased defecation "increase in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc18a2tm2Kmo/Slc18a2tm2Kmo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003963 abnormal corticosterone level "anomalous blood or tissue concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc18a2tm1Mca/Slc18a2+
Genetic Background: B6.129X1-Slc18a2tm1Mca

 MP:0003964 abnormal noradrenaline level "aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc18a2tm1Edw/Slc18a2tm1Edw
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Slc18a2tm1Edw/Slc18a2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Slc18a2tm2Kmo/Slc18a2tm2Kmo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004769 abnormal synaptic vesicle morphology "any structural anomaly of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
Show

Allelic Composition: Chrm3tm1Mmt/Chrm3tm1Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005322 abnormal serotonin level "anomalous concentration of biochemical messenger and regulator, found in the CNS, g.i. tract, and produced by platelets; it mediates neurotransmission, g.i. motility, hemostasis, and cardiovascular integrity " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Chrm3tm1Mmt/Chrm3tm1Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Slc18a2tm1Edw/Slc18a2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005445 abnormal neurotransmitter release "aberration in the secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Slc18a2tm1Edw/Slc18a2tm1Edw
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Slc18a2tm1Mca/Slc18a2+
Genetic Background: involves: 129X1/SvJ

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc18a2tm1Mca/Slc18a2tm1Mca
Genetic Background: involves: 129X1/SvJ

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc18a2tm1Mca/Slc18a2tm1Mca
Genetic Background: involves: 129X1/SvJ

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Slc18a2tm1Edw/Slc18a2tm1Edw
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Slc18a2tm1Edw/Slc18a2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Slc18a2tm2Kmo/Slc18a2tm2Kmo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Slc18a2tm1Mca/Slc18a2+
Genetic Background: involves: 129X1/SvJ

 MP:0008493 alpha-synuclein inclusion body "formation of aggregates of the alpha-synuclein protein in neural and glial tissue; often seen in neurodegenerative disorders such as Parkinson s disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc18a2tm2Kmo/Slc18a2tm2Kmo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008544 impaired olfaction "reduced ability to detect odors" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc18a2tm2Kmo/Slc18a2tm2Kmo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc18a2tm1Mca/Slc18a2+
Genetic Background: involves: 129X1/SvJ

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc18a2tm1Edw/Slc18a2tm1Edw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc18a2tm1Mca/Slc18a2tm1Mca
Genetic Background: involves: 129X1/SvJ

 MP:0009712 impaired conditioned place preference behavior "decrease in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf9tm1.2Fwan/Fgf9tm1.2Fwan
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Slc18a2tm1Mca/Slc18a2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009749 enhanced behavioral response to addictive substance "increased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf9tm1.2Fwan/Fgf9tm1.2Fwan
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Slc18a2tm1Mca/Slc18a2+
Genetic Background: involves: 129X1/SvJ

 MP:0009758 impaired behavioral response to cocaine "decreased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc18a2tm1Mca/Slc18a2+
Genetic Background: involves: 129X1/SvJ

 MP:0009854 delayed gastric emptying "an increase in the time required for solids or liquids to leave the stomach and enter the intestines" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc18a2tm2Kmo/Slc18a2tm2Kmo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010070 decreased serotonin concentration "reduction in the amount per unit of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Slc18a2tm2Kmo/Slc18a2tm2Kmo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Slc18a2tm1.1Bgir/Slc18a2tm1.1Bgir,Slc6a4tm1(cre)Xz/Slc6a4+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Slc18a2tm1Edw/Slc18a2tm1Edw
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Slc18a2tm1Mca/Slc18a2tm1Mca
Genetic Background: involves: 129X1/SvJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Slc18a2tm1.1Bgir/Slc18a2tm1.1Bgir,Slc6a4tm1(cre)Xz/Slc6a4+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Slc18a2tm2Kmo/Slc18a2tm2Kmo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011448 decreased dopaminergic neuron number "fewer than normal numbers of the neurons that utilize dopamine as a neurotransmitter" [MGI:smb]
Show

Allelic Composition: Slc18a2tm2Kmo/Slc18a2tm2Kmo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011451 increased susceptibility to dopaminergic neuron neurotoxicity "greater than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [MGI:csmith]
Show

Allelic Composition: Fgf9tm1.2Fwan/Fgf9tm1.2Fwan
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Slc18a2tm2Kmo/Slc18a2tm2Kmo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011479 abnormal catecholamine level "any anomaly in the amount of catecholamines, including adrenaline, noradrenaline and L-dopamine; catecholamines are act as hormones or neurotransmitters and are derived from the amino acid tyrosine" [MGI:csmith]
Show

Allelic Composition: Slc18a2tm1.1Bgir/Slc18a2tm1.1Bgir,Slc6a4tm1(cre)Xz/Slc6a4+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0020467 abnormal circadian behavior "any anomaly in the specific behavior of an organism that recurs with a regularity of approximately 24 hours" [GO:0048512]
Show

Allelic Composition: Slc18a2tm2Kmo/Slc18a2tm2Kmo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr