ENSMUSG00000025400


Mus musculus
tachykininTac2signalingpathwayweightreduceddelayeddecreasedprolongedneurokinin-btachykinin-neurokinin-likeconservedsitereceptorneuropeptideextracellularregionreceptorsbindtachykininsgalphaqsignallingeventscorporaluteaincreasedbodyfemale

Features
Gene ID: ENSMUSG00000025400
  
Biological name :Tac2
  
Synonyms : P55099 / Tac2 / Tachykinin-3 Neurokinin-B
  
Possible biological names infered from orthology : Q9UHF0 / TAC3 / tachykinin 3
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D3
Gene start: 127724478
Gene end: 127731768
  
Corresponding Affymetrix probe sets: 10367024 (MoGene1.0st)   1419411_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026466
Ensembl peptide - ENSMUSP00000136622
NCBI entrez gene - 21334     See in Manteia.
MGI - MGI:98476
RefSeq - NM_001199971
RefSeq - NM_009312
RefSeq Peptide - NP_001186900
RefSeq Peptide - NP_033338
swissprot - P55099
Ensembl - ENSMUSG00000025400
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TAC3ENSG00000166863Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003635  Neurokinin-B/Tachykinin-3
 IPR013055  Tachykinin/Neurokinin-like, conserved site


Gene Ontology (GO)
cell communicationcellular response to stimuluscell communicationcellular response to stimuluscell communicationcellular response to stimuluscell communicationcellular response to stimuluscell communicationcellular response to stimuluscell communicationcellular response to stimuluscell communicationcellular response to stimuluscell communicationcellular response to stimuluscell communicationcellular response to stimuluscell communicationcellular response to stimuluscell communicationcell communicationcellular response to stimuluscellular response to stimulus
extracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0007217 tachykinin receptor signaling pathway IEA
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 cellular_componentGO:0005576 extracellular region IEA


Pathways (from Reactome)
Pathway description
Tachykinin receptors bind tachykinins
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
endocrine/exocrine gland phenotypereproductive system phenotypegrowth/size phenotypehomeostasis/metabolism phenotypedigestive/alimentary phenotypeendocrine/exocrine gland phenotypereproductive system phenotypegrowth/size phenotypehomeostasis/metabolism phenotypedigestive/alimentary phenotypeendocrine/exocrine gland phenotypereproductive system phenotypegrowth/size phenotypehomeostasis/metabolism phenotypedigestive/alimentary phenotypeendocrine/exocrine gland phenotypereproductive system phenotypegrowth/size phenotypehomeostasis/metabolism phenotypedigestive/alimentary phenotypeendocrine/exocrine gland phenotypereproductive system phenotypegrowth/size phenotypehomeostasis/metabolism phenotypedigestive/alimentary phenotypeendocrine/exocrine gland phenotypereproductive system phenotypegrowth/size phenotypehomeostasis/metabolism phenotypedigestive/alimentary phenotypeendocrine/exocrine gland phenotypereproductive system phenotypegrowth/size phenotypehomeostasis/metabolism phenotypedigestive/alimentary phenotypeendocrine/exocrine gland phenotypereproductive system phenotypegrowth/size phenotypehomeostasis/metabolism phenotypedigestive/alimentary phenotypeendocrine/exocrine gland phenotypereproductive system phenotypegrowth/size phenotypehomeostasis/metabolism phenotypedigestive/alimentary phenotypeendocrine/exocrine gland phenotypereproductive system phenotypegrowth/size phenotypehomeostasis/metabolism phenotypedigestive/alimentary phenotypeendocrine/exocrine gland pheendocrine/exocrine gland phenotypereproductive system phenotypreproductive system phenotypegrowth/size phenotypegrowth/size phenotypehomeostasis/metabolism phenohomeostasis/metabolism phenotypedigestive/alimentary phenotydigestive/alimentary phenotype
IDPhenotypeDefinition Genetic BG
 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Lmnatm10Lgf/Lmnatm10Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Lmnatm10Lgf/Lmnatm10Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Lmnatm10Lgf/Lmnatm10Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001927 abnormal oestrous cycle (sensu Rodentia) "failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Lmnatm10Lgf/Lmnatm10Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lmnatm10Lgf/Lmnatm10Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001938 delayed sexual maturation "immaturity of the sexual organs at a given age" [J:61190]
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Allelic Composition: Lmnatm10Lgf/Lmnatm10Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoftm1(KOMP)Vlcg/Apof+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0002636 delayed vaginal opening "the opening of the genital canal in a female occuring at a later than expected age" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lmnatm10Lgf/Lmnatm10Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002790 decreased circulating follicle stimulating hormone level "less than expected blood concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmnatm10Lgf/Lmnatm10Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0003377 late onset of menarche "the onset of menstrual cycles occurs at a later age than normal" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Lmnatm10Lgf/Lmnatm10Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0003550 short perineum "reduced length of the area between the genital organs and the anus that lies beneath the pelvic diaphragm" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Lmnatm10Lgf/Lmnatm10Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0004856 decreased ovary weight "reduction in the average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lmnatm10Lgf/Lmnatm10Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0009011 prolonged diestrus "increase in the length of the diestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lmnatm10Lgf/Lmnatm10Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0009020 prolonged metestrus "increase in the length of the metestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lmnatm10Lgf/Lmnatm10Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028172 Tacr3 / P47937 / tachykinin receptor 3 / P29371*  / complex / reaction






 

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