Manteia - Molecule gene

ENSMUSG00000025515

Mus musculus

Features

Gene ID:	ENSMUSG00000025515

Biological name :	Muc2

Synonyms :	Muc2

Possible biological names infered from orthology :	mucin 2, oligomeric mucus/gel-forming

Species:	Mus musculus

Chr. number:	7
Strand:	1
Band:	F5
Gene start:	141690340
Gene end:	141754693

Corresponding Affymetrix probe sets:	1428435_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000136692 Ensembl peptide - ENSMUSP00000140349 Ensembl peptide - ENSMUSP00000140855 Ensembl peptide - ENSMUSP00000141040 Ensembl peptide - ENSMUSP00000141128 Ensembl peptide - ENSMUSP00000026590 Ensembl peptide - ENSMUSP00000139657 Ensembl peptide - ENSMUSP00000128250 MGI - MGI:1339364 swissprot - Q9R1L0 swissprot - A0A087WQU6 swissprot - A0A087WS13 swissprot - A0A087WSG8 swissprot - A0A087WSP1 swissprot - A0A140T8I8 swissprot - F6QGV1 swissprot - A0A087WP72 Ensembl - ENSMUSG00000025515

See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
MUC2	ENSG00000198788	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR001007	VWFC domain
IPR001846	von Willebrand factor, type D domain
IPR002919	Trypsin Inhibitor-like, cysteine rich domain
IPR006207	Cystine knot, C-terminal
IPR006208	Glycoprotein hormone subunit beta
IPR014853	Uncharacterised domain, cysteine-rich
IPR025155	WxxW domain
IPR028580	Mucin-2
IPR029034	Cystine-knot cytokine
IPR036084	Serine protease inhibitor-like superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0070701	mucus layer	IEA
molecular_function	GO:0005515	protein binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn Allelic Composition: Muc2^wnn/Muc2⁺ Genetic Background: C57BL/6-Muc2^wnn
MP:0000218	increased WBC count	"greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn Allelic Composition: Muc2^eey/Muc2^eey Genetic Background: C57BL/6-Muc2^eey
MP:0000351	increased cell proliferation	"greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dcn^tm1Ioz/Dcn⁺ Genetic Background: either: C.Cg-Dcn^tm1Ioz or C3.Cg-Dcn^tm1Ioz
MP:0000465	gastrointestinal hemorrhage	"bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]	Show Allelic Composition: Dcn^tm1Ioz/Dcn⁺ Genetic Background: either: C.Cg-Dcn^tm1Ioz or C3.Cg-Dcn^tm1Ioz
MP:0000477	abnormal intestine morphology	"malformation of the digestive tube passing from the stomach to the anus" [J:48968]	Show Allelic Composition: Dcn^tm1Ioz/Dcn⁺ Genetic Background: either: C.Cg-Dcn^tm1Ioz or C3.Cg-Dcn^tm1Ioz Allelic Composition: Muc2^eey/Muc2^wnn Genetic Background: C57BL/6-Muc2^eey/Muc2^wnn
MP:0000479	abnormal intestinal cell	"anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dcn^tm1Ioz/Dcn⁺ Genetic Background: either: C.Cg-Dcn^tm1Ioz or C3.Cg-Dcn^tm1Ioz
MP:0000493	rectal prolapse	"downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn Allelic Composition: Muc2^eey/Muc2^eey Genetic Background: C57BL/6-Muc2^eey
MP:0000495	abnormal colon morphology	"malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn Allelic Composition: Muc2^eey/Muc2^eey Genetic Background: C57BL/6-Muc2^eey
MP:0000511	abnormal intestinal mucosa morphology	"structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Dcn^tm1Ioz/Dcn⁺ Genetic Background: either: C.Cg-Dcn^tm1Ioz or C3.Cg-Dcn^tm1Ioz Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn
MP:0000512	intestinal ulcer	"lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn
MP:0000702	enlarged lymph nodes	"lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Muc2^keny/Muc2^keny Genetic Background: C57BL/6JAnu-Muc2^keny/Apb
MP:0001552	increased circulating triglyceride level	"higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]	Show Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn
MP:0001663	abnormal digestive system physiology	"altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Trpm5^tm1Sdmk/Trpm5^tm1Sdmk Genetic Background: involves: C57BL/6 Allelic Composition: Muc2^keny/Muc2^keny Genetic Background: C57BL/6JAnu-Muc2^keny/Apb
MP:0001666	abnormal nutrient absorption	"anomalous ability of the body to take in constituents of food necessary for normal physiologic function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Trpm5^tm1Sdmk/Trpm5^tm1Sdmk Genetic Background: involves: C57BL/6 Allelic Composition: Muc2^eey/Muc2^eey Genetic Background: C57BL/6-Muc2^eey
MP:0002816	colitis	"local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Dcn^tm1Ioz/Dcn⁺ Genetic Background: either: C.Cg-Dcn^tm1Ioz or C3.Cg-Dcn^tm1Ioz Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn
MP:0002957	intestinal adenocarcinoma	"malignant neoplasm of epithelial cells in the intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Dcn^tm1Ioz/Dcn⁺ Genetic Background: either: C.Cg-Dcn^tm1Ioz or C3.Cg-Dcn^tm1Ioz
MP:0003091	abnormal cell migration	"defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Dcn^tm1Ioz/Dcn⁺ Genetic Background: either: C.Cg-Dcn^tm1Ioz or C3.Cg-Dcn^tm1Ioz
MP:0003292	melena	"dark colored, foul-smelling feces due to the presence of blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn Allelic Composition: Muc2^eey/Muc2^eey Genetic Background: C57BL/6-Muc2^eey
MP:0003293	rectal hemorrhage	"bleeding in the rectum" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Muc2^wnn/Muc2⁺ Genetic Background: C57BL/6-Muc2^wnn
MP:0003304	large intestinal inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the large intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Dcn^tm1Ioz/Dcn⁺ Genetic Background: either: C.Cg-Dcn^tm1Ioz or C3.Cg-Dcn^tm1Ioz
MP:0003449	abnormal intestinal goblet cells	"malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]	Show Allelic Composition: Dcn^tm1Ioz/Dcn⁺ Genetic Background: either: C.Cg-Dcn^tm1Ioz or C3.Cg-Dcn^tm1Ioz Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn Allelic Composition: Muc2^wnn/Muc2⁺ Genetic Background: C57BL/6-Muc2^wnn Allelic Composition: Muc2^eey/Muc2^eey Genetic Background: C57BL/6-Muc2^eey
MP:0004842	abnormal large intestine crypts of Lieberkuhn morphology	"any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Dcn^tm1Ioz/Dcn⁺ Genetic Background: either: C.Cg-Dcn^tm1Ioz or C3.Cg-Dcn^tm1Ioz Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn Allelic Composition: Muc2^eey/Muc2^eey Genetic Background: C57BL/6-Muc2^eey
MP:0005013	increased lymphocyte number	"greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn
MP:0005036	diarrhea	"abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn Allelic Composition: Muc2^keny/Muc2^keny Genetic Background: C57BL/6JAnu-Muc2^keny/Apb
MP:0005621	abnormal cell physiology	"aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Dcn^tm1Ioz/Dcn⁺ Genetic Background: either: C.Cg-Dcn^tm1Ioz or C3.Cg-Dcn^tm1Ioz
MP:0006043	decreased apoptosis	"less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Dcn^tm1Ioz/Dcn⁺ Genetic Background: either: C.Cg-Dcn^tm1Ioz or C3.Cg-Dcn^tm1Ioz
MP:0008537	increased susceptibility to induced colitis	"increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn Allelic Composition: Muc2^M1Btlr/Muc2^M1Btlr Genetic Background: C57BL/6J-Muc2^M1Btlr Allelic Composition: Muc2^M1Btlr/Muc2⁺ Genetic Background: C57BL/6J-Muc2^M1Btlr Allelic Composition: Muc2^m2Btlr/? Genetic Background: C57BL/6J-Muc2^m2Btlr Allelic Composition: Muc2^wnn/Muc2⁺ Genetic Background: C57BL/6-Muc2^wnn Allelic Composition: Muc2^eey/Muc2^eey Genetic Background: C57BL/6-Muc2^eey Allelic Composition: Muc2^m3Btlr/Muc2^m3Btlr Genetic Background: C57BL/6J-Muc2^m3Btlr
MP:0008560	increased tumor necrosis factor secretion	"increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn Allelic Composition: Muc2^eey/Muc2^eey Genetic Background: C57BL/6-Muc2^eey
MP:0008566	increased interferon-gamma secretion	"increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn Allelic Composition: Muc2^eey/Muc2^eey Genetic Background: C57BL/6-Muc2^eey
MP:0008657	increased interleukin-1 beta secretion	"increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]	Show Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn Allelic Composition: Muc2^eey/Muc2^eey Genetic Background: C57BL/6-Muc2^eey
MP:0008672	increased interleukin-13 secretion	"increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]	Show Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn
MP:0008883	abnormal enterocyte proliferation	"anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dcn^tm1Ioz/Dcn⁺ Genetic Background: either: C.Cg-Dcn^tm1Ioz or C3.Cg-Dcn^tm1Ioz Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn Allelic Composition: Muc2^eey/Muc2^eey Genetic Background: C57BL/6-Muc2^eey
MP:0008884	abnormal enterocyte apoptosis	"change in the timing or the number of enterocytes undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dcn^tm1Ioz/Dcn⁺ Genetic Background: either: C.Cg-Dcn^tm1Ioz or C3.Cg-Dcn^tm1Ioz
MP:0008885	increased enterocyte apoptosis	"increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn Allelic Composition: Muc2^eey/Muc2^eey Genetic Background: C57BL/6-Muc2^eey
MP:0009378	abnormal endoplasmic reticulum morphology	"any structural anomaly of irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells" [GO:0005783]	Show Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn Allelic Composition: Muc2^eey/Muc2^eey Genetic Background: C57BL/6-Muc2^eey
MP:0009482	ileum inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the ileum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn Allelic Composition: Muc2^eey/Muc2^eey Genetic Background: C57BL/6-Muc2^eey
MP:0009766	increased sensitivity to xenobiotic induced morbidity/mortality	"decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn
MP:0010155	abnormal intestine physiology	"any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dcn^tm1Ioz/Dcn⁺ Genetic Background: either: C.Cg-Dcn^tm1Ioz or C3.Cg-Dcn^tm1Ioz Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn
MP:0010180	increased susceptibility to weight loss	"greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn
MP:0011632	dilated mitochondria	"the luminal space of the mitochondria is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith]	Show Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn Allelic Composition: Muc2^eey/Muc2^eey Genetic Background: C57BL/6-Muc2^eey
MP:0011635	abnormal mitochondrial crista morphology	"Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061]	Show Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn Allelic Composition: Muc2^eey/Muc2^eey Genetic Background: C57BL/6-Muc2^eey
MP:0013956	decreased colon length	"reduced length of the portion of the large intestine between the cecum and the rectum" [ISBN:0683400088]	Show Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn
MP:0020354	increased endoplasmic reticulum stress	"increase in in the accumulation of misfolded or unfolded proteins in the endoplasmic reticulum lumen; this accumulation may be stimulated by genetic or enviromental factors" [ORCID: orcid.org/0000-0003-4606-0597]	Show Allelic Composition: Muc2^wnn/Muc2^wnn Genetic Background: C57BL/6-Muc2^wnn Allelic Composition: Muc2^eey/Muc2^eey Genetic Background: C57BL/6-Muc2^eey

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr