Manteia

ENSMUSG00000025576

Mus musculus

Features

Gene ID:	ENSMUSG00000025576

Biological name :	Rbfox3

Synonyms :	Q8BIF2 / Rbfox3 / RNA binding 3

Possible biological names infered from orthology :	A6NFN3 / RNA binding fox-1 homolog 3

Species:	Mus musculus

Chr. number:	11
Strand:	-1
Band:	E2
Gene start:	118489762
Gene end:	118911597

Corresponding Affymetrix probe sets:	10393594 (MoGene1.0st) 1427286_at (Mouse Genome 430 2.0 Array) 1436450_at (Mouse Genome 430 2.0 Array) 1456149_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000118332 Ensembl peptide - ENSMUSP00000113987 Ensembl peptide - ENSMUSP00000119255 Ensembl peptide - ENSMUSP00000017576 Ensembl peptide - ENSMUSP00000069598 Ensembl peptide - ENSMUSP00000099312 Ensembl peptide - ENSMUSP00000101885 Ensembl peptide - ENSMUSP00000113636 NCBI entrez gene - 52897 See in Manteia. MGI - MGI:106368 RefSeq - XM_017314663 RefSeq - NM_001285437 RefSeq - NM_001285438 RefSeq - XM_006533722 RefSeq - XM_006533725 RefSeq - XM_006533726 RefSeq - XM_006533727 RefSeq - XM_011249132 RefSeq - XM_017314661 RefSeq - XM_017314662 RefSeq - NM_001024931 RefSeq - NM_001039167 RefSeq - NM_001039168 RefSeq - NM_001285436 RefSeq Peptide - NP_001034256 RefSeq Peptide - NP_001034257 RefSeq Peptide - NP_001272365 RefSeq Peptide - NP_001272366 RefSeq Peptide - NP_001272367 RefSeq Peptide - NP_001020102 swissprot - A2A4W9 swissprot - B7ZC11 swissprot - Q8BIF2 Ensembl - ENSMUSG00000025576

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
rbfox3a	ENSDARG00000010083	Danio rerio
rbfox3b	ENSDARG00000074310	Danio rerio
RBFOX3	ENSGALG00000032889	Gallus gallus
A6NFN3	ENSG00000167281	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Q9JJ43 / Rbfox1 / RNA binding 1 / Q9NWB1* / RNA binding fox-1 homolog 1*	ENSMUSG00000008658	60
Q8BP71 / Rbfox2 / Mus musculus RNA binding protein, fox-1 homolog (C. elegans) 2 (Rbfox2), transcript variant 10, mRNA. / O43251* / RNA binding fox-1 homolog 2*	ENSMUSG00000033565	59

Protein motifs (from Interpro)

Interpro ID	Name
IPR000504	RNA recognition motif domain
IPR017325	RNA binding protein Fox-1
IPR025670	Fox-1 C-terminal domain
IPR034237	FOX1, RNA recognition motif
IPR035979	RNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	IDA
biological_process	GO:0006397	mRNA processing	IEA
biological_process	GO:0007399	nervous system development	IBA
biological_process	GO:0008380	RNA splicing	IEA
biological_process	GO:0043484	regulation of RNA splicing	IEA
cellular_component	GO:0005622	intracellular	IDA
cellular_component	GO:0005634	nucleus	IDA
cellular_component	GO:0005737	cytoplasm	IDA
cellular_component	GO:0043025	neuronal cell body	IDA
cellular_component	GO:0043204	perikaryon	IDA
molecular_function	GO:0003676	nucleic acid binding	IEA
molecular_function	GO:0003677	DNA binding	IDA
molecular_function	GO:0003723	RNA binding	IEA
molecular_function	GO:0003729	mRNA binding	IBA
molecular_function	GO:0005515	protein binding	IPI

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001364	decreased anxiety-related response	"when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]	Show Allelic Composition: Casc3^{Gt(RRU345)Byg}/Casc3^{tm1(KOMP)Vlcg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Casc3^{Gt(RRU345)Byg}/Casc3^{tm1(KOMP)Vlcg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0001458	abnormal object recognition memory	"defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]	Show Allelic Composition: Casc3^{Gt(RRU345)Byg}/Casc3^{tm1(KOMP)Vlcg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0001475	reduced long term depression	"less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]	Show Allelic Composition: Casc3^{Gt(RRU345)Byg}/Casc3^{tm1(KOMP)Vlcg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0001900	impaired synaptic plasticity	"decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Casc3^{Gt(RRU345)Byg}/Casc3^{tm1(KOMP)Vlcg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0002175	low brain weight	"lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Casc3^{Gt(RRU345)Byg}/Casc3^{tm1(KOMP)Vlcg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0002206	abnormal CNS synaptic transmission	"defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Casc3^{Gt(RRU345)Byg}/Casc3^{tm1(KOMP)Vlcg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0002733	abnormal thermal nociception	"abnormal capability to sense pain elicited by thermal stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Casc3^{Gt(RRU345)Byg}/Casc3^{tm1(KOMP)Vlcg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0002906	susceptibility to pharmacologically induced seizures	"inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]	Show Allelic Composition: Casc3^{Gt(RRU345)Byg}/Casc3^{tm1(KOMP)Vlcg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0002912	abnormal excitatory postsynaptic potential	"defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Casc3^{Gt(RRU345)Byg}/Casc3^{tm1(KOMP)Vlcg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0002920	reduced paired-pulse facilitation	"decrease in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Casc3^{Gt(RRU345)Byg}/Casc3^{tm1(KOMP)Vlcg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0002966	decreased circulating alkaline phosphatase level	"reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Mysm1^{tm1a(KOMP)Wtsi}/Mysm1⁺ Genetic Background: Not Specified
MP:0004753	abnormal miniature excitatory postsynaptic currents	"defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Casc3^{Gt(RRU345)Byg}/Casc3^{tm1(KOMP)Vlcg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0004981	decreased neuronal precursor cell number	"reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Casc3^{Gt(RRU345)Byg}/Casc3^{tm1(KOMP)Vlcg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0008026	abnormal brain white matter morphology	"any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Casc3^{Gt(RRU345)Byg}/Casc3^{tm1(KOMP)Vlcg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0008921	increased neurotransmitter release	"increased production or release of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Casc3^{Gt(RRU345)Byg}/Casc3^{tm1(KOMP)Vlcg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0009435	abnormal miniature inhibitory postsynaptic currents	"defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Casc3^{Gt(RRU345)Byg}/Casc3^{tm1(KOMP)Vlcg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0009766	increased sensitivity to xenobiotic induced morbidity/mortality	"decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Casc3^{Gt(RRU345)Byg}/Casc3^{tm1(KOMP)Vlcg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0009936	abnormal dendritic spine morphology	"any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Casc3^{Gt(RRU345)Byg}/Casc3^{tm1(KOMP)Vlcg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0009937	abnormal neuron differentiation	"abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Casc3^{Gt(RRU345)Byg}/Casc3^{tm1(KOMP)Vlcg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0009938	abnormal hippocampus granule cell morphology	"any structural anomaly of the small neurons of the hippocampal granule cell layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Casc3^{Gt(RRU345)Byg}/Casc3^{tm1(KOMP)Vlcg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0009939	abnormal hippocampus neuron morphology		Show Allelic Composition: Casc3^{Gt(RRU345)Byg}/Casc3^{tm1(KOMP)Vlcg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0010053	decreased grip strength	"reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Mysm1^{tm1a(KOMP)Wtsi}/Mysm1⁺ Genetic Background: Not Specified
MP:0012006	abnormal hippocampus physiology	"any functional anomaly related to processes in the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [MPD:Molly]	Show Allelic Composition: Casc3^{Gt(RRU345)Byg}/Casc3^{tm1(KOMP)Vlcg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0012307	impaired spatial learning	"impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]	Show Allelic Composition: Casc3^{Gt(RRU345)Byg}/Casc3^{tm1(KOMP)Vlcg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0020335	abnormal dentate gyrus neuron dendrite morphology	"any structural anomaly of the highly branched tree-like process of a neuron in one of two interlocking gyri of the hippocampus formation" [ORCID: orcid.org/0000-0003-4606-0597]	Show Allelic Composition: Casc3^{Gt(RRU345)Byg}/Casc3^{tm1(KOMP)Vlcg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0020357	abnormal excitatory synapse morphology	"any structural anomaly of a synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell" [GO:0060076]	Show Allelic Composition: Casc3^{Gt(RRU345)Byg}/Casc3^{tm1(KOMP)Vlcg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0020394	decreased neuronal precursor proliferation	"reduction in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:anna]	Show Allelic Composition: Casc3^{Gt(RRU345)Byg}/Casc3^{tm1(KOMP)Vlcg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr