ENSMUSG00000025716


Mus musculus

Features
Gene ID: ENSMUSG00000025716
  
Biological name :Myo3a
  
Synonyms : Myo3a / myosin-IIIa
  
Possible biological names infered from orthology : Q8NEV4
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A3
Gene start: 22227503
Gene end: 22618252
  
Corresponding Affymetrix probe sets: 10469637 (MoGene1.0st)   1431983_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046329
Ensembl peptide - ENSMUSP00000120573
Ensembl peptide - ENSMUSP00000116185
NCBI entrez gene - 667663     See in Manteia.
MGI - MGI:2183924
RefSeq - NM_148413
RefSeq Peptide - NP_680779
swissprot - B1AYY3
swissprot - A2ASW0
swissprot - F6QNG5
Ensembl - ENSMUSG00000025716
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myo3aENSDARG00000010186Danio rerio
 MYO3AENSGALG00000007647Gallus gallus
 MYO3AENSG00000095777Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myo3b / Q1EG27 / Myosin-IIIb / Q8WXR4*ENSMUSG0000004206446
Myo16 / Q5DU14 / Unconventional myosin-XVI / Q9Y6X6* / myosin XVI*ENSMUSG0000003905723
Myo19 / Q5SV80 / Unconventional myosin-XIX / Q96H55* / myosin XIX*ENSMUSG0000002052716


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000719  Protein kinase domain
 IPR001609  Myosin head, motor domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036083  Class III myosin, motor domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007018 microtubule-based movement IEA
 cellular_componentGO:0016459 myosin complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cops5tm1Fxc/Cops5tm1Fxc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004402 decreased cochlear outer hair cell number "decreased number (or less than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cops5tm1Fxc/Cops5tm1Fxc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cops5tm1Fxc/Cops5tm1Fxc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004408 decreased cochlear hair cell number "decreased number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cops5tm1Fxc/Cops5tm1Fxc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cops5tm1Fxc/Cops5tm1Fxc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011275 abnormal behavioral response to light "unexpected change in the activity of an organism (in terms of movement, outward responses) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light" [GO:0009416, MGI:llw2]
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Allelic Composition: Mmachctm1.1(NCOM)Mfgc/Mmachctm1.1(NCOM)Mfgc
Genetic Background: C57BL/6N-Mmachctm1.1(NCOM)Mfgc/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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