ENSMUSG00000025739


Mus musculus

Features
Gene ID: ENSMUSG00000025739
  
Biological name :Gng13
  
Synonyms : Gng13 / guanine nucleotide binding protein (G protein), gamma 13 / Q9JMF3
  
Possible biological names infered from orthology : G protein subunit gamma 13 / Q9P2W3
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.3
Gene start: 25717171
Gene end: 25719406
  
Corresponding Affymetrix probe sets: 10442829 (MoGene1.0st)   1419414_at (Mouse Genome 430 2.0 Array)   1447282_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110760
Ensembl peptide - ENSMUSP00000131648
NCBI entrez gene - 64337     See in Manteia.
MGI - MGI:1925616
RefSeq - XM_006524779
RefSeq - NM_022422
RefSeq Peptide - NP_071867
RefSeq Peptide - NP_001344711
swissprot - Q9JMF3
Ensembl - ENSMUSG00000025739
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gng13bENSDARG00000037921Danio rerio
 GNG13ENSGALG00000005293Gallus gallus
 GNG13ENSG00000127588Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015898  G-protein gamma-like domain
 IPR036284  G-protein gamma-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0050909 sensory perception of taste IDA
 cellular_componentGO:0005834 heterotrimeric G-protein complex IPI
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0030425 dendrite IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0031681 G-protein beta-subunit binding ISS


Pathways (from Reactome)
Pathway description
Glucagon signaling in metabolic regulation
G-protein activation
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
ADP signalling through P2Y purinoceptor 12
G beta:gamma signalling through PI3Kgamma
Prostacyclin signalling through prostacyclin receptor
Adrenaline,noradrenaline inhibits insulin secretion
Ca2+ pathway
G alpha (q) signalling events
G alpha (12/13) signalling events
G beta:gamma signalling through PLC beta
G alpha (s) signalling events
ADP signalling through P2Y purinoceptor 1
G alpha (i) signalling events
G alpha (z) signalling events
Glucagon-type ligand receptors
Thromboxane signalling through TP receptor
Vasopressin regulates renal water homeostasis via Aquaporins
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001102 small superior vagus ganglion "reduced size of the upper ganglion of the vagus nerve located at the jugular foramen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Gnao1tm1b(EUCOMM)Hmgu/Gnao1+
Genetic Background: C57BL/6N-Gnao1tm1b(EUCOMM)Hmgu/H

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Sec24ctm1d(EUCOMM)Wtsi/Sec24c+,Sec24dGt(RRT226)Byg/Sec24d+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N * FVB/N

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Sec24ctm1d(EUCOMM)Wtsi/Sec24c+,Sec24dGt(RRT226)Byg/Sec24d+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N * FVB/N

 MP:0001983 abnormal olfactory system physiology "abnormal function of the system relating to smell " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nr2c2tm1Bbm/Nr2c2tm1Bbm,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnao1tm1b(EUCOMM)Hmgu/Gnao1+
Genetic Background: C57BL/6N-Gnao1tm1b(EUCOMM)Hmgu/H

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Gnao1tm1b(EUCOMM)Hmgu/Gnao1+
Genetic Background: C57BL/6N-Gnao1tm1b(EUCOMM)Hmgu/H

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sec24ctm1d(EUCOMM)Wtsi/Sec24c+,Sec24dGt(RRT226)Byg/Sec24d+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N * FVB/N

 MP:0005499 abnormal olfactory system morphology "anomalous structure of the organs involved in smell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gng13tm1Liqh/Gng13tm1Liqh,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0008544 impaired olfaction "reduced ability to detect odors" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gng13tm1Liqh/Gng13tm1Liqh,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gng13tm1Liqh/Gng13tm1Liqh,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnao1tm1b(EUCOMM)Hmgu/Gnao1+
Genetic Background: C57BL/6N-Gnao1tm1b(EUCOMM)Hmgu/H

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gnao1tm1b(EUCOMM)Hmgu/Gnao1+
Genetic Background: C57BL/6N-Gnao1tm1b(EUCOMM)Hmgu/H

 MP:0011677 abnormal olfactory sensory neuron physiology "any functional anomaly of cells that innervate the olfactory epithelium and are responsible for receiving and transmitting odorant signals" [MGI:csmith]
Show

Allelic Composition: Gng13tm1Liqh/Gng13tm1Liqh,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000023439 Gnb3 / Q61011 / guanine nucleotide binding protein (G protein), beta 3 / P16520* / G protein subunit beta 3*  / complex
 ENSMUSG00000028777 Gnat3 / Q3V3I2 / guanine nucleotide binding protein, alpha transducing 3 / A8MTJ3* / G protein subunit alpha transducin 3*  / complex






 

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