ENSMUSG00000025777


Mus musculus

Features
Gene ID: ENSMUSG00000025777
  
Biological name :Gdap1
  
Synonyms : Ganglioside-induced differentiation-associated protein 1 / Gdap1 / O88741
  
Possible biological names infered from orthology : Q8TB36
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: A3
Gene start: 17145362
Gene end: 17164271
  
Corresponding Affymetrix probe sets: 10344973 (MoGene1.0st)   1423328_at (Mouse Genome 430 2.0 Array)   1423329_at (Mouse Genome 430 2.0 Array)   1437425_at (Mouse Genome 430 2.0 Array)   1450940_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140406
Ensembl peptide - ENSMUSP00000026879
NCBI entrez gene - 14545     See in Manteia.
MGI - MGI:1338002
RefSeq - NM_010267
RefSeq Peptide - NP_034397
swissprot - A0A087WQZ4
swissprot - O88741
Ensembl - ENSMUSG00000025777
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gdap1ENSDARG00000058601Danio rerio
 GDAP1ENSGALG00000042798Gallus gallus
 GDAP1ENSG00000104381Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8VE33 / Gdap1l1 / Ganglioside-induced differentiation-associated protein 1-like 1 / Q96MZ0*ENSMUSG0000001794353


Protein motifs (from Interpro)
Interpro ID Name
 IPR004045  Glutathione S-transferase, N-terminal
 IPR010987  Glutathione S-transferase, C-terminal-like
 IPR034336  Ganglioside-induced differentiation-associated protein 1
 IPR036249  Thioredoxin-like superfamily
 IPR036282  Glutathione S-transferase, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000266 mitochondrial fission IEA
 biological_processGO:0006626 protein targeting to mitochondrion IEA
 biological_processGO:0006749 glutathione metabolic process IBA
 biological_processGO:0008053 mitochondrial fusion IEA
 biological_processGO:0032526 response to retinoic acid IDA
 biological_processGO:0071305 cellular response to vitamin D IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031307 integral component of mitochondrial outer membrane IEA
 molecular_functionGO:0004364 glutathione transferase activity IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
Show

Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
Show

Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
Show

Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002883 chromatolysis "the dissolution of the granules of chromophil substance in a nerve cell body that may occur in injured cells or axons" [dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
Show

Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gdap1tm1.1Ics/Gdap1tm1.1Ics
Genetic Background: Not Specified

 MP:0004231 abnormal calcium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004768 abnormal axonal transport "any functional anomaly of the directed movement of organelles or vesicles along microtubules in nerve cell axons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Gdap1tm1.1Ics/Gdap1tm1.1Ics
Genetic Background: Not Specified

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Gdap1tm1.1Ics/Gdap1tm1.1Ics
Genetic Background: Not Specified

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
Show

Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Gdap1tm1Ics/Gdap1tm1Ics,Tg(Mpz-cre)26Mes/0
Genetic Background: involves: FVB/NTac

Allelic Composition: Gdap1tm1.1Ics/Gdap1tm1.1Ics
Genetic Background: Not Specified

 MP:0009378 abnormal endoplasmic reticulum morphology "any structural anomaly of irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells" [GO:0005783]
Show

Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011630 increased mitochondria size "enlarged the cellular organelles responsible for energy production" [MGI:csmith]
Show

Allelic Composition: Clec4a2tm1Yiw/Clec4a2tm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Gdap1tm1.1Ics/Gdap1tm1.1Ics
Genetic Background: Not Specified

 MP:0011638 abnormal mitochondrial chromosome morphology "any structrual anomaly of the chromosome found in the mitochondrion of a eukaryotic cell" [GO:0000262]
Show

Allelic Composition: Gdap1tm1.1Ics/Gdap1tm1.1Ics
Genetic Background: Not Specified

 MP:0013438 dysmyelination "reduced amount of myelin present in the form of a myelin sheath surrounding an axon due to defects in the synthesis and formation of myelin" [MGI:csmith]
Show

Allelic Composition: Gdap1tm1Ics/Gdap1tm1Ics,Tg(Mpz-cre)26Mes/0
Genetic Background: involves: FVB/NTac

Allelic Composition: Gdap1tm1.1Ics/Gdap1tm1.1Ics
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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