ENSMUSG00000025867


Mus musculus

Features
Gene ID: ENSMUSG00000025867
  
Biological name :Cplx2
  
Synonyms : Complexin-2 / Cplx2 / P84086
  
Possible biological names infered from orthology : Q6PUV4
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: B1
Gene start: 54371349
Gene end: 54383917
  
Corresponding Affymetrix probe sets: 10405253 (MoGene1.0st)   1421477_at (Mouse Genome 430 2.0 Array)   1436383_at (Mouse Genome 430 2.0 Array)   1455672_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026985
NCBI entrez gene - 12890     See in Manteia.
MGI - MGI:104726
RefSeq - XM_017315376
RefSeq - NM_009946
RefSeq - XM_017315375
RefSeq Peptide - NP_034076
swissprot - P84086
Ensembl - ENSMUSG00000025867
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cplx2ENSDARG00000061918Danio rerio
 ENSGALG00000027920Gallus gallus
 CPLX2ENSG00000145920Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cplx1 / P63040 / Complexin-1 / O14810*ENSMUSG0000003361584


Protein motifs (from Interpro)
Interpro ID Name
 IPR008849  Synaphin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0016079 synaptic vesicle exocytosis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031915 positive regulation of synaptic plasticity IDA
 biological_processGO:0043303 mast cell degranulation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031201 SNARE complex IEA
 cellular_componentGO:0042629 mast cell granule IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex IEA
 molecular_functionGO:0000149 SNARE binding IEA
 molecular_functionGO:0017075 syntaxin-1 binding IEA
 molecular_functionGO:0019905 syntaxin binding IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001362 abnormal anxiety-related response "altered emotional response related to anticipation of a non-specific threat" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: B6NCrl.Cg-Cplx2tm1Rmnd

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

Allelic Composition: Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: B6NCrl.Cg-Cplx2tm1Rmnd

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0001440 abnormal grooming behavior "defects in the standard of behavior of cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0001442 decreased grooming behavior "reduced amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0001446 whisker trimming "biting of the whiskers or facial hair by cagemates" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

Allelic Composition: Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: B6NCrl.Cg-Cplx2tm1Rmnd

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Thrbtm1.1Syc/Thrbtm1.1Syc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss

Allelic Composition: Cplx2tm1Tyag/Cplx2tm1Tyag
Genetic Background: B6.Cg-Cplx2tm1Tyag

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: B6NCrl.Cg-Cplx2tm1Rmnd

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: B6NCrl.Cg-Cplx2tm1Rmnd

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0002065 abnormal fear/anxiety-related behavior "altered response in tests for fear or anxiety related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
Show

Allelic Composition: Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: B6NCrl.Cg-Cplx2tm1Rmnd

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0005357 retropulsion "when placed in a new environment, mice will walk backwards and then may walk forwards, whereas wild type mice will immediately walk forward, or freeze momentarily and then walk forward" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:79604]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0005445 abnormal neurotransmitter release "aberration in the secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0005507 tail dragging "pulling the tail along with difficulty or effort; may be due to paralysis or weakness" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0008414 abnormal spatial reference memory "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: B6NCrl.Cg-Cplx2tm1Rmnd

 MP:0008911 induced hyperactivity "increased physical activity following stimulation such as handling, touching or noise" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: B6NCrl.Cg-Cplx2tm1Rmnd

 MP:0010746 abnormal pre-Botzinger complex physiology "any functional anomaly of the group of interneurons within the medulla oblongata s ventral respiratory group that are important for the generation of ventilatory (inspiratory) rhythmogenesis" [PMID:18826652]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0020083 decreased hippocampus volume "decrease from the average range of the hippocampus volume compared to normal" [GOC:NV]
Show

Allelic Composition: Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: B6NCrl.Cg-Cplx2tm1Rmnd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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