ENSMUSG00000026064


Mus musculus

Features
Gene ID: ENSMUSG00000026064
  
Biological name :Ptp4a1
  
Synonyms : protein tyrosine phosphatase 4a1 / Ptp4a1 / Q63739
  
Possible biological names infered from orthology : protein tyrosine phosphatase type IVA, member 1 / Q93096
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: B
Gene start: 30940302
Gene end: 30949770
  
Corresponding Affymetrix probe sets: 10353707 (MoGene1.0st)   10463068 (MoGene1.0st)   10467489 (MoGene1.0st)   10469575 (MoGene1.0st)   10548563 (MoGene1.0st)   1419024_at (Mouse Genome 430 2.0 Array)   1438657_x_at (Mouse Genome 430 2.0 Array)   1449322_at (Mouse Genome 430 2.0 Array)   1455002_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110861
Ensembl peptide - ENSMUSP00000143884
Ensembl peptide - ENSMUSP00000027232
NCBI entrez gene - 19243     See in Manteia.
MGI - MGI:1277096
RefSeq - XM_006495798
RefSeq - XM_006495799
RefSeq - NM_011200
RefSeq Peptide - NP_035330
swissprot - Q63739
swissprot - B9EKL6
swissprot - A0A0J9YTW7
Ensembl - ENSMUSG00000026064
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptp4a1ENSDARG00000006242Danio rerio
 PTP4A1ENSGALG00000016271Gallus gallus
 PTP4A1ENSG00000112245Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O70274 / Ptp4a2 / Protein tyrosine phosphatase type IVA 2 / Q12974* / protein tyrosine phosphatase type IVA, member 2*ENSMUSG0000002878885
Ptp4a3 / Q9D658 / Protein tyrosine phosphatase type IVA 3 / O75365* / protein tyrosine phosphatase type IVA, member 3*ENSMUSG0000005989575


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome TAS
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0004727 prenylated protein tyrosine phosphatase activity TAS
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Avptm1Chron/Avptm1Chron
Genetic Background: involves: C57BL/6N

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1+,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1+,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1+,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1+,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1+,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1+,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1+,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1+,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1+,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Avptm1Chron/Avptm1Chron
Genetic Background: involves: C57BL/6N

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Avptm1Chron/Avptm1Chron
Genetic Background: involves: C57BL/6N

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1+,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0014052 increased male germ cell apoptosis "greater number of male germs cells that undergo programmed cell death" [MGI:csmith]
Show

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1+,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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