ENSMUSG00000026110


Mus musculus

Features
Gene ID: ENSMUSG00000026110
  
Biological name :Mgat4a
  
Synonyms : Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form / Mgat4a / Q812G0
  
Possible biological names infered from orthology : mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A / Q9UM21
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: B
Gene start: 37439340
Gene end: 37541016
  
Corresponding Affymetrix probe sets: 10354003 (MoGene1.0st)   1435641_at (Mouse Genome 430 2.0 Array)   1444347_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118692
Ensembl peptide - ENSMUSP00000115778
Ensembl peptide - ENSMUSP00000121181
Ensembl peptide - ENSMUSP00000122909
Ensembl peptide - ENSMUSP00000038894
Ensembl peptide - ENSMUSP00000114175
NCBI entrez gene - 269181     See in Manteia.
MGI - MGI:2662992
RefSeq - XM_017320967
RefSeq - XM_006496026
RefSeq - XM_011238526
RefSeq - XM_017320961
RefSeq - XM_017320964
RefSeq - XM_017320965
RefSeq - XM_017320966
RefSeq - NM_001290801
RefSeq - NM_173870
RefSeq - XM_006496022
RefSeq - XM_006496024
RefSeq Peptide - NP_001277730
RefSeq Peptide - NP_776295
swissprot - D6RG46
swissprot - D3Z166
swissprot - Q812G0
swissprot - D3YZH7
Ensembl - ENSMUSG00000026110
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mgat4aENSDARG00000063330Danio rerio
 MGAT4AENSGALG00000030780Gallus gallus
 MGAT4AENSG00000071073Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mgat4b / Q812F8 / Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B / Q9UQ53* / mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B*ENSMUSG0000003662061
Mgat4c / Q9D306 / Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C / Q9UBM8* / MGAT4 family member C*ENSMUSG0000001988827
Mgat4d / Q9D4R2 / Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D / A6NG13* / MGAT4 family member D*ENSMUSG0000003505727
A6H684 / Mgat4e / Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4E ENSMUSG0000004636717
4933406M09Rik / RIKEN cDNA 4933406M09 geneENSMUSG0000005052617


Protein motifs (from Interpro)
Interpro ID Name
 IPR006759  Glycosyl transferase family 54


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006487 protein N-linked glycosylation IGI
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008375 acetylglucosaminyltransferase activity IDA
 molecular_functionGO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IDA
 molecular_functionGO:0016758 transferase activity, transferring hexosyl groups IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
N-Glycan antennae elongation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Mgat4atm1.1Jxm/Mgat4atm1.1Jxm,Mgat4btm1.1Jxm/Mgat4btm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001560 abnormal circulating insulin level "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0003926 impaired cellular glucose import "reduced ability of a cell to take in glucose from the environment" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
Show

Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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