ENSMUSG00000026303


Mus musculus

Features
Gene ID: ENSMUSG00000026303
  
Biological name :Mlph
  
Synonyms : melanophilin / Mlph
  
Possible biological names infered from orthology : Q9BV36
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: D
Gene start: 90915085
Gene end: 90951142
  
Corresponding Affymetrix probe sets: 10348471 (MoGene1.0st)   1425586_a_at (Mouse Genome 430 2.0 Array)   1449896_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027528
Ensembl peptide - ENSMUSP00000123314
NCBI entrez gene - 171531     See in Manteia.
MGI - MGI:2176380
RefSeq - NM_053015
RefSeq - XM_006529231
RefSeq Peptide - NP_443748
swissprot - D3Z049
swissprot - A0A0R4J075
Ensembl - ENSMUSG00000026303
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mlphaENSDARG00000070991Danio rerio
 mlphbENSDARG00000062481Danio rerio
 MLPHENSGALG00000003904Gallus gallus
 MLPHENSG00000115648Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myrip / Q8K3I4 / Rab effector MyRIP / Q8NFW9* / myosin VIIA and Rab interacting protein*ENSMUSG0000004179425
Mobp / Q9D2P8 / Myelin-associated oligodendrocyte basic protein / Q13875*ENSMUSG000000325176


Protein motifs (from Interpro)
Interpro ID Name
 IPR006788  Rab effector MyRIP/Melanophilin
 IPR010911  Rab-binding domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR037442  Melanophilin, FYVE-related domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0017022 myosin binding IEA
 molecular_functionGO:0017137 Rab GTPase binding IEA
 molecular_functionGO:0030674 protein binding, bridging IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc12a6tm1Tjj/Slc12a6tm1Tjj
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: l1Rk3/Mlphln
Genetic Background: involves: C57L/J

Allelic Composition: a/a,Mlphln/Mlphln,Tyrp1b/Tyrp1b
Genetic Background: C57L/J

Allelic Composition: Mc1re/Mc1re,Mlphln/Mlphln
Genetic Background: Not Specified

Allelic Composition: Mlphln/Mlphln,Mregdsu/Mregdsu
Genetic Background: involves: C57BR

Allelic Composition: Mlphln-Btlr/Mlphln-Btlr
Genetic Background: C57BL/6J-Mlphln-Btlr

Allelic Composition: a/a,Mlphln/Mlphln
Genetic Background: Not Specified

Allelic Composition: Mlphln-2Btlr/Mlphln-2Btlr
Genetic Background: C57BL/6J-Mlphln-2Btlr

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: a/a,Mlphln/Mlphln,Tyrp1b/Tyrp1b
Genetic Background: C57L/J

Allelic Composition: a/a,Mlphln/Mlphln
Genetic Background: Not Specified

 MP:0002877 abnormal melanocyte morphology "malformation of the cells that produce pigment " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: a/a,Mlphln/Mlphln,Tyrp1b/Tyrp1b
Genetic Background: C57L/J

 MP:0004381 abnormal hair follicle melanocyte morphology "any structural anomaly of the cells that produce pigment in the hair follicles" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: a/a,Mlphln/Mlphln
Genetic Background: Not Specified

 MP:0005607 decreased bleeding time "less than the normal duration of blood flow after skin puncture; indicative of platement and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Mib1tm1Kong/Mib1tm1Kong
Genetic Background: involves: 129P2/OlaHsd

 MP:0008733 abnormal hair shaft melanin granule distribution "disruption in the regular arrangement of pigment polymers in the hair shaft" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: a/a,Mlphln/Mlphln
Genetic Background: Not Specified

 MP:0009555 abnormal hair follicle melanin granule distribution "anomaly in the spatial arrangement of particles produced by melanocytes that confer color in the hair follicle" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: a/a,Mlphln/Mlphln
Genetic Background: involves: C57BL/J * C57BR

 MP:0010193 abnormal choroid melanin granule morphology "any structural anomaly of the pigment particles in the choroid" [ISBN-13:978-1-4051-2034-0 "The Pigmentary System, Second Edition"]
Show

Allelic Composition: a/a,Mlphln/Mlphln
Genetic Background: involves: C57BL/J * C57BR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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