ENSMUSG00000026587


Mus musculus

Features
Gene ID: ENSMUSG00000026587
  
Biological name :Astn1
  
Synonyms : Astn1 / Astrotactin-1 / Q61137
  
Possible biological names infered from orthology : O14525
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H1
Gene start: 158362273
Gene end: 158691781
  
Corresponding Affymetrix probe sets: 10350896 (MoGene1.0st)   1418615_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141260
Ensembl peptide - ENSMUSP00000142322
Ensembl peptide - ENSMUSP00000142017
Ensembl peptide - ENSMUSP00000141580
Ensembl peptide - ENSMUSP00000141518
Ensembl peptide - ENSMUSP00000141498
Ensembl peptide - ENSMUSP00000039711
Ensembl peptide - ENSMUSP00000127428
NCBI entrez gene - 11899     See in Manteia.
MGI - MGI:1098567
RefSeq - XM_011238740
RefSeq - NM_001205204
RefSeq - NM_007495
RefSeq - XM_011238739
RefSeq Peptide - NP_031521
RefSeq Peptide - NP_001192133
swissprot - A0A0A6YXJ4
swissprot - Q3TPU9
swissprot - Q3UHD7
swissprot - A0A0A6YWE6
swissprot - A0A0A6YWD1
swissprot - A0A0A6YWJ9
swissprot - A0A0A6YVT7
swissprot - Q61137
Ensembl - ENSMUSG00000026587
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 astn1ENSDARG00000068323Danio rerio
 ASTN1ENSGALG00000004472Gallus gallus
 ASTN1ENSG00000152092Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Astn2 / Q80Z10 / Astrotactin-2 / O75129*ENSMUSG0000002837349


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR003961  Fibronectin type III
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR013783  Immunoglobulin-like fold
 IPR020864  Membrane attack complex component/perforin (MACPF) domain
 IPR026995  Astrotactin
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007158 neuron cell-cell adhesion IDA
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0098609 cell-cell adhesion IMP
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043204 perikaryon IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002762 ectopic granule cells "granule cell body resides in a place other than the external or internal granule layer of the cerebellum" [J:4978]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004098 abnormal granule neuron "any structural anomaly of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006099 thin granule layer "reduced thickness of the innermost cortical layer of the cerebellum that contains granule cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009977 abnormal cerebellar granule cell migration "defective or impaired movement of cerebellar granule cell neurons from the germinal zone into the granule cell layer of the cerebellum during development of the cerebellar cortex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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