ENSMUSG00000026857


Mus musculus

Features
Gene ID: ENSMUSG00000026857
  
Biological name :Ntmt1
  
Synonyms : Mus musculus N-terminal Xaa-Pro-Lys N-methyltransferase 1 (Ntmt1), transcript variant 3, mRNA. / Ntmt1 / Q8R2U4
  
Possible biological names infered from orthology : N-terminal Xaa-Pro-Lys N-methyltransferase 1 / Q9BV86
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: B
Gene start: 30807826
Gene end: 30823033
  
Corresponding Affymetrix probe sets: 10471062 (MoGene1.0st)   1451278_a_at (Mouse Genome 430 2.0 Array)   1456340_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116760
Ensembl peptide - ENSMUSP00000123140
Ensembl peptide - ENSMUSP00000142189
Ensembl peptide - ENSMUSP00000141905
Ensembl peptide - ENSMUSP00000141900
Ensembl peptide - ENSMUSP00000141222
Ensembl peptide - ENSMUSP00000035303
NCBI entrez gene - 66617     See in Manteia.
MGI - MGI:1913867
RefSeq - NM_170592
RefSeq - XM_006498230
RefSeq - XM_006498229
RefSeq - XM_006498228
RefSeq - XM_006498226
RefSeq - NM_001356434
RefSeq - NM_001356435
RefSeq Peptide - NP_001343362
RefSeq Peptide - NP_001343363
RefSeq Peptide - NP_001343364
RefSeq Peptide - NP_733480
swissprot - A2APZ2
swissprot - Q8R2U4
swissprot - A0A0A6YVQ9
swissprot - A2APZ3
swissprot - A0A0A6YX97
swissprot - A0A0A6YXY1
Ensembl - ENSMUSG00000026857
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ntmt1ENSDARG00000022399Danio rerio
 NTMT1ENSGALG00000017611Gallus gallus
 NTMT1ENSG00000148335Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
B2RXM4 / Mettl11b / Alpha N-terminal protein methyltransferase 1B / Q5VVY1* / methyltransferase like 11B*ENSMUSG0000004011349


Protein motifs (from Interpro)
Interpro ID Name
 IPR008576  Alpha-N-methyltransferase NTM1
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006480 N-terminal protein amino acid methylation IEA
 biological_processGO:0007051 spindle organization IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0016571 histone methylation IEA
 biological_processGO:0018012 N-terminal peptidyl-alanine trimethylation IDA
 biological_processGO:0018013 N-terminal peptidyl-glycine methylation IEA
 biological_processGO:0018016 N-terminal peptidyl-proline dimethylation IDA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0035570 N-terminal peptidyl-serine methylation IBA
 biological_processGO:0035572 N-terminal peptidyl-serine dimethylation IEA
 biological_processGO:0035573 N-terminal peptidyl-serine trimethylation IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008276 protein methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042054 histone methyltransferase activity IEA
 molecular_functionGO:0071885 N-terminal protein N-methyltransferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0,Tg(tetO-MAPT)32Lms/0
Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0,Tg(tetO-MAPT)32Lms/0
Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0,Tg(tetO-MAPT)32Lms/0
Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0,Tg(tetO-MAPT)32Lms/0
Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0,Tg(tetO-MAPT)32Lms/0
Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0,Tg(tetO-MAPT)32Lms/0
Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0,Tg(tetO-MAPT)32Lms/0
Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0,Tg(tetO-MAPT)32Lms/0
Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0,Tg(tetO-MAPT)32Lms/0
Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

 MP:0002016 ovarian cysts "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0,Tg(tetO-MAPT)32Lms/0
Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0,Tg(tetO-MAPT)32Lms/0
Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

 MP:0003103 liver degeneration "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653]
Show

Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0,Tg(tetO-MAPT)32Lms/0
Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0,Tg(tetO-MAPT)32Lms/0
Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

 MP:0003786 premature aging "earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764]
Show

Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0,Tg(tetO-MAPT)32Lms/0
Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

 MP:0005114 premature hair loss "release of fur at an earlier than expected time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0,Tg(tetO-MAPT)32Lms/0
Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0,Tg(tetO-MAPT)32Lms/0
Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

 MP:0008412 increased cellular sensitivity to oxidative stress "greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0,Tg(tetO-MAPT)32Lms/0
Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

 MP:0008869 anovulation "complete failure of ovum to be released from an ovarian follicle" [MESH:C13.351.500.056.630.050, MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0,Tg(tetO-MAPT)32Lms/0
Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

 MP:0009932 skin fibrosis "invasion of fibrous connective tissue into the skin, often resulting from inflammation or injury" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0,Tg(tetO-MAPT)32Lms/0
Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0,Tg(tetO-MAPT)32Lms/0
Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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