ENSMUSG00000026983


Mus musculus

Features
Gene ID: ENSMUSG00000026983
  
Biological name :Il1f5
  
Synonyms : Il1f5 / Interleukin-36 receptor antagonist protein / Q9QYY1
  
Possible biological names infered from orthology : IL36RN / interleukin 36 receptor antagonist / Q9UBH0
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A3
Gene start: 24276954
Gene end: 24283426
  
Corresponding Affymetrix probe sets: 10469801 (MoGene1.0st)   1421370_a_at (Mouse Genome 430 2.0 Array)   1426507_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126028
Ensembl peptide - ENSMUSP00000141512
Ensembl peptide - ENSMUSP00000028360
Ensembl peptide - ENSMUSP00000110134
Ensembl peptide - ENSMUSP00000116122
NCBI entrez gene - 54450     See in Manteia.
MGI - MGI:1859325
RefSeq - NM_001146087
RefSeq - NM_001146088
RefSeq - NM_019451
RefSeq Peptide - NP_001139560
RefSeq Peptide - NP_062324
RefSeq Peptide - NP_001139559
swissprot - Q9QYY1
swissprot - A0A0A6YWE1
swissprot - A2AIA8
Ensembl - ENSMUSG00000026983
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL36RNENSG00000136695Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Il1rn / P25085 / Interleukin-1 receptor antagonist protein / P18510* / interleukin 1 receptor antagonist*ENSMUSG0000002698146
Il1f10 / Q8R459 / Interleukin-1 family member 10 / Q8WWZ1*ENSMUSG0000004684543


Protein motifs (from Interpro)
Interpro ID Name
 IPR000975  Interleukin-1 family
 IPR003297  Interleukin-1 receptor antagonist/Interleukin-36
 IPR008996  Cytokine IL1/FGF
 IPR020877  Interleukin-1 conserved site
 IPR027171  Interleukin-36 receptor antagonist


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001960 negative regulation of cytokine-mediated signaling pathway ISO
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0019732 antifungal humoral response ISO
 biological_processGO:0032700 negative regulation of interleukin-17 production ISO
 biological_processGO:0032715 negative regulation of interleukin-6 production IGI
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:1902714 negative regulation of interferon-gamma secretion ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005149 interleukin-1 receptor binding IBA
 molecular_functionGO:0005152 interleukin-1 receptor antagonist activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-36 pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: PfasSofa-2J/Pfas+
Genetic Background: B6(Cg)-PfasSofa-2J/GrsrJ

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: PfasSofa-2J/Pfas+
Genetic Background: B6(Cg)-PfasSofa-2J/GrsrJ

 MP:0000676 abnormal water content "more or less than the normal total amount of water retained in the body" [il:Ira Lu, Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc
Genetic Background: B6.129S7-Hoxa9tm1Mrc

 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
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Allelic Composition: PfasSofa-2J/Pfas+
Genetic Background: B6(Cg)-PfasSofa-2J/GrsrJ

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
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Allelic Composition: Il1f5tm1Hblu/Il1f5+,Tg(KRT14-Il1f6)1Hblu/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0001193 psoriasis "chronic skin lesions characterized by inflammation and silvery-scaly patches" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: PfasSofa-2J/Pfas+
Genetic Background: B6(Cg)-PfasSofa-2J/GrsrJ

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: PfasSofa-2J/Pfas+
Genetic Background: B6(Cg)-PfasSofa-2J/GrsrJ

 MP:0001195 flaky skin "shedding scales on the skin " [J:56641]
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Allelic Composition: PfasSofa-2J/Pfas+
Genetic Background: B6(Cg)-PfasSofa-2J/GrsrJ

 MP:0001200 thick skin "greater depth of skin " [J:47225]
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Allelic Composition: Il1f5tm1Hblu/Il1f5+,Tg(KRT14-Il1f6)1Hblu/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0001208 blistering "accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis" [J:65039]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc
Genetic Background: B6.129S7-Hoxa9tm1Mrc

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: PfasSofa-2J/Pfas+
Genetic Background: B6(Cg)-PfasSofa-2J/GrsrJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc
Genetic Background: B6.129S7-Hoxa9tm1Mrc

 MP:0001874 acanthosis "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: PfasSofa-2J/Pfas+
Genetic Background: B6(Cg)-PfasSofa-2J/GrsrJ

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc
Genetic Background: B6.129S7-Hoxa9tm1Mrc

Allelic Composition: Il1f5tm1Hblu/Il1f5+,Tg(KRT14-Il1f6)1Hblu/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc
Genetic Background: B6.129S7-Hoxa9tm1Mrc

 MP:0003427 parakeratosis "abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc
Genetic Background: B6.129S7-Hoxa9tm1Mrc

Allelic Composition: Il1f5tm1Hblu/Il1f5+,Tg(KRT14-Il1f6)1Hblu/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0004938 dilated vasculature "stretched or widened aperture of the luminal space of the network of tubes that carries blood through the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc
Genetic Background: B6.129S7-Hoxa9tm1Mrc

Allelic Composition: Il1f5tm1Hblu/Il1f5+,Tg(KRT14-Il1f6)1Hblu/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc
Genetic Background: B6.129S7-Hoxa9tm1Mrc

Allelic Composition: Il1f5tm1Hblu/Il1f5+,Tg(KRT14-Il1f6)1Hblu/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: PfasSofa-2J/Pfas+
Genetic Background: B6(Cg)-PfasSofa-2J/GrsrJ

 MP:0009675 orthokeratosis "thickening of the stratum corneum of the epidermis (hyperkeratosis) with non-nucleated keratinocytes retained in this layer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc
Genetic Background: B6.129S7-Hoxa9tm1Mrc

Allelic Composition: Il1f5tm1Hblu/Il1f5+,Tg(KRT14-Il1f6)1Hblu/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc
Genetic Background: B6.129S7-Hoxa9tm1Mrc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000070942 Il1rl2 / Q9ERS7 / Mus musculus interleukin 1 receptor-like 2 (Il1rl2), transcript variant 2, mRNA. / Q9HB29* / interleukin 1 receptor like 2*  / complex / reaction






 

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