ENSMUSG00000027007


Mus musculus

Features
Gene ID: ENSMUSG00000027007
  
Biological name :Ssfa2
  
Synonyms : Q922B9 / Sperm-specific antigen 2 homolog / Ssfa2
  
Possible biological names infered from orthology : P28290 / sperm specific antigen 2
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: C3
Gene start: 79635352
Gene end: 79672966
  
Corresponding Affymetrix probe sets: 10473160 (MoGene1.0st)   1423613_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107414
Ensembl peptide - ENSMUSP00000107418
Ensembl peptide - ENSMUSP00000107415
NCBI entrez gene - 70599     See in Manteia.
MGI - MGI:1917849
RefSeq - NM_080558
RefSeq Peptide - NP_542125
swissprot - A2AQD6
swissprot - A2AQD5
swissprot - Q922B9
Ensembl - ENSMUSG00000027007
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ssfa2ENSDARG00000038938Danio rerio
 SSFA2ENSGALG00000008903Gallus gallus
 SSFA2ENSG00000138434Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q14B48 / Ccdc129 / Coiled-coil domain-containing protein 129 / Q6ZRS4* / coiled-coil domain containing 129*ENSMUSG0000003797314
Q3U132 / Tespa1 / Protein TESPA1 / A2RU30* / thymocyte expressed, positive selection associated 1*ENSMUSG000000348339


Protein motifs (from Interpro)
Interpro ID Name
 IPR026648  Sperm-specific antigen 2
 IPR029325  KRAP, ITPR-interacting domain
 IPR029326  Sperm-specific antigen 2, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Esr1tm1Arnal/Esr1tm1Arnal,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Esr1tm1Arnal/Esr1tm1Arnal,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Esr1tm1Arnal/Esr1tm1Arnal,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Esr1tm1Arnal/Esr1tm1Arnal,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Esr1tm1Arnal/Esr1tm1Arnal,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Esr1tm1Arnal/Esr1tm1Arnal,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Esr1tm1Arnal/Esr1tm1Arnal,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004892 increased adiponectin level "greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Esr1tm1Arnal/Esr1tm1Arnal,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Esr1tm1Arnal/Esr1tm1Arnal,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Esr1tm1Arnal/Esr1tm1Arnal,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Esr1tm1Arnal/Esr1tm1Arnal,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Esr1tm1Arnal/Esr1tm1Arnal,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005479 decreased circulating triiodothyronine level "less than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Esr1tm1Arnal/Esr1tm1Arnal,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Esr1tm1Arnal/Esr1tm1Arnal,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Esr1tm1Arnal/Esr1tm1Arnal,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Esr1tm1Arnal/Esr1tm1Arnal,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Esr1tm1Arnal/Esr1tm1Arnal,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0008965 increased basal metabolism "increase in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0009269 decreased fat cell size "reduction in the size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0009289 decreased epididymal fat pad weight 
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0014169 decreased brown adipose tissue mass "decreased physical bulk or volume of brown adipose tissue" [MGI:csmith]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0030016 increased adipocyte glucose uptake "increased ability of adipocytes to take in glucose" [MGI:anna]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr