ENSMUSG00000027322


Mus musculus

Features
Gene ID: ENSMUSG00000027322
  
Biological name :Siglec1
  
Synonyms : sialic acid binding Ig-like lectin 1, sialoadhesin / Siglec1
  
Possible biological names infered from orthology : Q9BZZ2 / sialic acid binding Ig like lectin 1
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: F1
Gene start: 131069220
Gene end: 131086765
  
Corresponding Affymetrix probe sets: 10487823 (MoGene1.0st)   1422161_at (Mouse Genome 430 2.0 Array)   1427668_at (Mouse Genome 430 2.0 Array)   1427706_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028794
Ensembl peptide - ENSMUSP00000105855
Ensembl peptide - ENSMUSP00000105856
NCBI entrez gene - 20612     See in Manteia.
MGI - MGI:99668
RefSeq - XM_006499051
RefSeq - NM_011426
RefSeq - XM_006499049
RefSeq - XM_006499050
RefSeq Peptide - NP_035556
swissprot - H9KUZ3
swissprot - H9KUZ2
swissprot - G3X8X6
Ensembl - ENSMUSG00000027322
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9BZZ2ENSG00000088827Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cd22 / CD22 molecule / P20273*ENSMUSG0000003057712
Vcam1 / P29533 / vascular cell adhesion molecule 1 / P19320*ENSMUSG000000279628


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013106  Immunoglobulin V-set domain
 IPR013151  Immunoglobulin
 IPR013162  CD80-like, immunoglobulin C2-set
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0030246 carbohydrate binding IEA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cebpatm1Btp/Cebpatm1Btp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Siglec1tm2.1Croc/Siglec1tm2.1Croc
Genetic Background: B6.129P2(C)-Siglec1tm2.1Croc

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cebpatm1Btp/Cebpatm1Btp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Siglec1tm2.1Croc/Siglec1tm2.1Croc
Genetic Background: B6.129P2(C)-Siglec1tm2.1Croc

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cebpatm1Btp/Cebpatm1Btp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cebpatm1Btp/Cebpatm1Btp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Cebpatm1Btp/Cebpatm1Btp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005000 immune tolerance "the failure to respond to an antigen " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpatm1Btp/Cebpatm1Btp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpatm1Btp/Cebpatm1Btp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Cebpatm1Btp/Cebpatm1Btp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008240 abnormal spleen marginal zone macrophage morphology "any structural anomaly of the cells present in the splenic marginal zone and are involved in the recognition and clearance of material, such as pathogen-derived material, from the splenic circulation" [PMID:16322748]
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Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008241 abnormal metallophilic macrophage morphology "any structural anomaly of the macrophage cells that surround the white pulp of the spleen, adjacent to the marginal sinus" [PMID:16322748]
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Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Cebpatm1Btp/Cebpatm1Btp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Siglec1tm2.1Croc/Siglec1tm2.1Croc
Genetic Background: B6.129P2(C)-Siglec1tm2.1Croc

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Cebpatm1Btp/Cebpatm1Btp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Cebpatm1Btp/Cebpatm1Btp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Siglec1tm2.1Croc/Siglec1tm2.1Croc
Genetic Background: B6.129P2(C)-Siglec1tm2.1Croc

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Cebpatm1Btp/Cebpatm1Btp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Cebpatm1Btp/Cebpatm1Btp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Cebpatm1Btp/Cebpatm1Btp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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