ENSMUSG00000027394


Mus musculus

Features
Gene ID: ENSMUSG00000027394
  
Biological name :Ttl
  
Synonyms : P38585 / Ttl / tubulin tyrosine ligase
  
Possible biological names infered from orthology : Q8NG68
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F1
Gene start: 129065942
Gene end: 129096283
  
Corresponding Affymetrix probe sets: 10475957 (MoGene1.0st)   1427112_at (Mouse Genome 430 2.0 Array)   1427113_s_at (Mouse Genome 430 2.0 Array)   1447964_at (Mouse Genome 430 2.0 Array)   1451630_at (Mouse Genome 430 2.0 Array)   1460484_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046883
Ensembl peptide - ENSMUSP00000117506
NCBI entrez gene - 69737     See in Manteia.
MGI - MGI:1916987
RefSeq - NM_027192
RefSeq Peptide - NP_081468
swissprot - F6ZXS5
swissprot - P38585
Ensembl - ENSMUSG00000027394
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ttlENSDARG00000062418Danio rerio
 TTLENSGALG00000008614Gallus gallus
 TTLENSG00000114999Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004344  Tubulin-tyrosine ligase/Tubulin polyglutamylase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IMP
 biological_processGO:0006464 cellular protein modification process IEA
 biological_processGO:0018166 C-terminal protein-tyrosinylation IEA
 biological_processGO:0030516 regulation of axon extension IMP
 biological_processGO:0045931 positive regulation of mitotic cell cycle IEA
 biological_processGO:0090235 regulation of metaphase plate congression IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005874 microtubule IC
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004835 tubulin-tyrosine ligase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Frem2my-F11/Frem2my-F11
Genetic Background: either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus)

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
Show

Allelic Composition: Frem2my-F11/Frem2my-F11
Genetic Background: either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus)

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Frem2my-F11/Frem2my-F11
Genetic Background: either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus)

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Frem2my-F11/Frem2my-F11
Genetic Background: either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus)

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Frem2my-F11/Frem2my-F11
Genetic Background: either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus)

 MP:0008129 absent brain internal capsule "absence of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Frem2my-F11/Frem2my-F11
Genetic Background: either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus)

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Frem2my-F11/Frem2my-F11
Genetic Background: either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus)

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Frem2my-F11/Frem2my-F11
Genetic Background: either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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