ENSMUSG00000027510


Mus musculus

Features
Gene ID: ENSMUSG00000027510
  
Biological name :Rbm38
  
Synonyms : Q62176 / Rbm38 / RNA-binding protein 38
  
Possible biological names infered from orthology : Q9H0Z9 / RNA binding motif protein 38
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H3
Gene start: 173020498
Gene end: 173034734
  
Corresponding Affymetrix probe sets: 10479041 (MoGene1.0st)   1421265_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133816
Ensembl peptide - ENSMUSP00000029014
Ensembl peptide - ENSMUSP00000133388
Ensembl peptide - ENSMUSP00000133464
Ensembl peptide - ENSMUSP00000133681
Ensembl peptide - ENSMUSP00000133757
NCBI entrez gene - 56190     See in Manteia.
MGI - MGI:1889294
RefSeq - XM_006499924
RefSeq - NM_019547
RefSeq Peptide - NP_062420
swissprot - G3UXN1
swissprot - G3UWX7
swissprot - G3UWQ8
swissprot - Q62176
swissprot - G3UXG4
Ensembl - ENSMUSG00000027510
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rbm38ENSDARG00000058818Danio rerio
 RBM38ENSGALG00000026081Gallus gallus
 RBM38ENSG00000132819Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rbm24 / D3Z4I3 / RNA-binding protein 24 / Q9BX46* / RNA binding motif protein 24*ENSMUSG0000003813268


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
 biological_processGO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008285 negative regulation of cell proliferation ISO
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0010830 regulation of myotube differentiation IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0043484 regulation of RNA splicing ISO
 biological_processGO:0070935 3"-UTR-mediated mRNA stabilization ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IMP
 molecular_functionGO:0003730 mRNA 3"-UTR binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tg(SFTPC-Il18)AThos/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2

 MP:0000162 lordosis "anteriorly convex curvature of the spine, "saddle back" " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62022]
Show

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tg(SFTPC-Il18)AThos/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tg(SFTPC-Il18)AThos/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tg(SFTPC-Il18)AThos/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tg(SFTPC-Il18)AThos/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tg(SFTPC-Il18)AThos/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2

 MP:0001209 spontaneous skin ulceration "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
Show

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tg(SFTPC-Il18)AThos/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tg(SFTPC-Il18)AThos/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tg(SFTPC-Il18)AThos/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2

 MP:0001658 increased mortality induced by gamma-irradiation "greater sensitivity to doses of ionizing radiation" [J:51834]
Show

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tg(SFTPC-Il18)AThos/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tg(SFTPC-Il18)AThos/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbm38tm1.1Xch/Rbm38tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

Allelic Composition: Rbm38tm1.1Xch/Rbm38tm1.1Xch,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tg(SFTPC-Il18)AThos/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2

Allelic Composition: Rbm38tm1.1Xch/Rbm38tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

Allelic Composition: Rbm38tm1.1Xch/Rbm38tm1.1Xch,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0002166 altered tumor susceptibility/resistance "greater than or less than the average number of tumors, usually a specific type, arising in a given strain when compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rbm38tm1.1Xch/Rbm38tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

Allelic Composition: Rbm38tm1.1Xch/Rbm38tm1.1Xch,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tg(SFTPC-Il18)AThos/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Rbm38tm1.1Xch/Rbm38tm1.1Xch,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tg(SFTPC-Il18)AThos/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2

 MP:0003010 decreased mortality induced by ionizing radiation "reduced sensitivity to lethal doses of ionizing radiation such as ultraviolet light, X-rays, or gamma rays" [smb:Susan M. Bello , Mouse Genome Informatics Curator, J:88888]
Show

Allelic Composition: Rbm38tm1.1Xch/Rbm38tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
Show

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tg(SFTPC-Il18)AThos/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2

 MP:0003786 premature aging "earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764]
Show

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tg(SFTPC-Il18)AThos/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tg(SFTPC-Il18)AThos/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Rbm38tm1.1Xch/Rbm38tm1.1Xch,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tg(SFTPC-Il18)AThos/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tg(SFTPC-Il18)AThos/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tg(SFTPC-Il18)AThos/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2

 MP:0010264 increased hepatoma incidence "greater than the expected number of malignant tumors composed of neoplastic liver cells in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tg(SFTPC-Il18)AThos/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rbm38tm1.1Xch/Rbm38tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0012415 decreased sarcoma incidence "less than the expected number of a connective tissue neoplasm associated with the proliferation of embryonically-derived mesodermal cells, occurring in a specific population in a given time period" [DOID:1115]
Show

Allelic Composition: Rbm38tm1.1Xch/Rbm38tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tg(SFTPC-Il18)AThos/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2

Allelic Composition: Rbm38tm1.1Xch/Rbm38tm1.1Xch,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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