ENSMUSG00000027720


Mus musculus

Features
Gene ID: ENSMUSG00000027720
  
Biological name :Il2
  
Synonyms : Il2 / Interleukin-2 / P04351
  
Possible biological names infered from orthology : P60568
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: B
Gene start: 37120523
Gene end: 37125959
  
Corresponding Affymetrix probe sets: 10497878 (MoGene1.0st)   1447917_x_at (Mouse Genome 430 2.0 Array)   1449990_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029275
NCBI entrez gene - 16183     See in Manteia.
MGI - MGI:96548
RefSeq - NM_008366
RefSeq Peptide - NP_032392
swissprot - P04351
Ensembl - ENSMUSG00000027720
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL2ENSG00000109471Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000779  Interleukin-2
 IPR009079  Four-helical cytokine-like, core
 IPR030477  Interleukin-2, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002366 leukocyte activation involved in immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002903 negative regulation of B cell apoptotic process IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030890 positive regulation of B cell proliferation IEA
 biological_processGO:0032729 positive regulation of interferon-gamma production IDA
 biological_processGO:0032740 positive regulation of interleukin-17 production IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IMP
 biological_processGO:0042104 positive regulation of activated T cell proliferation IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046013 regulation of T cell homeostatic proliferation IMP
 biological_processGO:0048304 positive regulation of isotype switching to IgG isotypes IMP
 biological_processGO:0050672 negative regulation of lymphocyte proliferation IMP
 biological_processGO:0050728 negative regulation of inflammatory response IMP
 biological_processGO:0051024 positive regulation of immunoglobulin secretion IMP
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IDA
 biological_processGO:2000320 negative regulation of T-helper 17 cell differentiation IGI
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity ISO
 molecular_functionGO:0005134 interleukin-2 receptor binding ISO
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
RAF/MAP kinase cascade
Interleukin-2 signaling
Interleukin receptor SHC signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000172 abnormal bone marrow cell number "Increased or decreased number of cells that make up the core cavities of bones when compared to the norm" [MGI:tc]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C.129P2-Il2tm1Hor

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C.129P2-Il2tm1Hor

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Igh-Jtm1Dhu/Igh-Jtm1Dhu,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Igh-Jtm1Dhu/Igh-J+,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Rag2tm1Fwa/Rag2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0000491 crypt abscesses "an exudate collection associated with inflammation in the crypts of Lieberkuhn of the intestinal mucosa; often associated with ulcerative colitis" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0000493 rectal prolapse "downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Igh-Jtm1Dhu/Igh-Jtm1Dhu,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Igh-Jtm1Dhu/Igh-J+,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Rag2tm1Fwa/Rag2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0000512 intestinal ulcer "lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0000604 amyloidosis "an accumulation of extracellular amyloid in tissues of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0000613 abnormal salivary gland morphology "malformed saliva-secreting glands of the oral cavity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak
Genetic Background: D2.129-Il2rbtm1Mak

 MP:0000623 reduced salivation "decrease flow, secretion, or amount of saliva" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak
Genetic Background: D2.129-Il2rbtm1Mak

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C.129P2-Il2tm1Hor

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C.129P2-Il2tm1Hor

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C.129P2-Il2tm1Hor

Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: B6.129P2-Il2tm1Hor/J

 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Igh-Jtm1Dhu/Igh-Jtm1Dhu,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Igh-Jtm1Dhu/Igh-J+,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Rag2tm1Fwa/Rag2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Igh-Jtm1Dhu/Igh-J+,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Rag2tm1Fwa/Rag2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0001665 chronic diarrhea "prolonged diarrhea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: B6.129P2-Il2tm1Hor/J

Allelic Composition: Il2m1/Il2m1
Genetic Background: MRL/MpJ

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C.129P2-Il2tm1Hor

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Tg(DO11.10)10Dlo/?
Genetic Background: C.Cg-Il2tm1Hor Tg(DO11.10)10Dlo

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C.129P2-Il2tm1Hor

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C.129P2-Il2tm1Hor

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C.129P2-Il2tm1Hor

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C.129P2-Il2tm1Hor

 MP:0001864 vasculitis "inflammation of a blood or lymph vessel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C.129P2-Il2tm1Hor

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C.129P2-Il2tm1Hor

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak
Genetic Background: D2.129-Il2rbtm1Mak

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C.129P2-Il2tm1Hor

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Tg(DO11.10)10Dlo/?
Genetic Background: C.Cg-Il2tm1Hor Tg(DO11.10)10Dlo

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002424 abnormal reticulocyte morphology/development "anomalous structure, formation, or numbers of immature erthrocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C.129P2-Il2tm1Hor

 MP:0002425 altered susceptibility to autoimmune disorder "a change in the likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc25a13tm1Lct/Slc25a13+
Genetic Background: either: 129/Sv-Slc25a13tm1Lct or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igh-Jtm1Dhu/Igh-Jtm1Dhu,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0002436 abnormal cytotoxic T cell morphology/development "anomalous structure, formation, or numbers of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129 * C57BL/6

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C.129P2-Il2tm1Hor

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002594 low mean erythrocyte count "less than average numbers of red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C.129P2-Il2tm1Hor

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C.129P2-Il2tm1Hor

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Igh-Jtm1Dhu/Igh-Jtm1Dhu,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Igh-Jtm1Dhu/Igh-J+,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Rag2tm1Fwa/Rag2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0002957 intestinal adenocarcinoma "malignant neoplasm of epithelial cells in the intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129 * C57BL/6

 MP:0003132 increased number of pre-B cells "greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003293 rectal hemorrhage "bleeding in the rectum" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Igh-Jtm1Dhu/Igh-Jtm1Dhu,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Igh-Jtm1Dhu/Igh-J+,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Rag2tm1Fwa/Rag2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0003304 large intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the large intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: B6.129P2-Il2tm1Hor/J

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
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Allelic Composition: Igh-Jtm1Dhu/Igh-Jtm1Dhu,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Igh-Jtm1Dhu/Igh-J+,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Rag2tm1Fwa/Rag2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0003850 abnormal thymocyte activation/response "anomaly in the process of producing activated thymocytes from naive thymocytes" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0004751 increased length of allograft survival "compared to controls, a greater length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpx3tm1Hjco/Gpx3tm1Hjco,Selenoptm1Rfb/Selenoptm1Rfb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0004827 increased susceptibility to autoimmune hemolytic anemia "greater likelihood that an organism will develop an abnormality of the immune system that destroys red blood cells (hemolysis) prematurely" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C.129P2-Il2tm1Hor

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C.129P2-Il2tm1Hor

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Tg(DO11.10)10Dlo/?
Genetic Background: C.Cg-Il2tm1Hor Tg(DO11.10)10Dlo

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Tg(Pgk1-HA)1.1Vbo/?,Tg(Tcra/Tcrb)1Vbo/?
Genetic Background: C.Cg-Il2tm1Hor Tg(Pgk1-HA)1.1Vbo Tg(Tcra/Tcrb)1Vbo

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor,Tg(Pgk1-HA)1.1Vbo/?,Tg(Tcra/Tcrb)1Vbo/?
Genetic Background: C.Cg-Il2tm1Hor Tg(Pgk1-HA)1.1Vbo Tg(Tcra/Tcrb)1Vbo

Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129P2/OlaHsd

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor,Tg(Pgk1-HA)1.1Vbo/?,Tg(Tcra/Tcrb)1Vbo/?
Genetic Background: C.Cg-Il2tm1Hor Tg(Pgk1-HA)1.1Vbo Tg(Tcra/Tcrb)1Vbo

Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: B6.129P2-Il2tm1Hor/J

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129 * C57BL/6

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C.129P2-Il2tm1Hor

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Igh-Jtm1Dhu/Igh-Jtm1Dhu,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Igh-Jtm1Dhu/Igh-J+,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Rag2tm1Fwa/Rag2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0005042 abnormal level of surface class II molecules "deviation from the normal concentration of major histocompatibility complex class II molecules expressed at the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: B6.129P2-Il2tm1Hor/J

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Igh-Jtm1Dhu/Igh-Jtm1Dhu,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Igh-Jtm1Dhu/Igh-J+,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Rag2tm1Fwa/Rag2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C.129P2-Il2tm1Hor

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C.129P2-Il2tm1Hor

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C.129P2-Il2tm1Hor

Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: B6.129P2-Il2tm1Hor

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Tg(DO11.10)10Dlo/?
Genetic Background: C.Cg-Il2tm1Hor Tg(DO11.10)10Dlo

 MP:0005350 increased susceptibility to autoimmune disorders "greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: B6.129P2-Il2tm1Hor/J

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129 * C57BL/6

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C.129P2-Il2tm1Hor

 MP:0005671 response to transplant "the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: B6.129P2-Il2tm1Hor/J

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: B6.129P2-Il2tm1Hor

Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C3.129P2-Il2tm1Hor

Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: B6.129P2-Il2tm1Hor/J

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129 * C57BL/6

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: B6.129P2-Il2tm1Hor

Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C3.129P2-Il2tm1Hor

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008088 abnormal T-helper 1 cell differentiation "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C.129P2-Il2tm1Hor

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008177 increased germinal center B cell number "greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C.129P2-Il2tm1Hor

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008349 abnormal gamma-delta intraepithelial T cell morphology "any structural anomaly of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000801, ISBN:0781735149]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008401 abnormal CD8 positive, alpha-beta intraepithelial T cell morphology "any structural anomaly of a CD8-positive, alpha-beta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129 * C57BL/6

 MP:0008466 enlarged mesenteric lymph nodes "increased size of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Igh-Jtm1Dhu/Igh-Jtm1Dhu,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Igh-Jtm1Dhu/Igh-J+,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Rag2tm1Fwa/Rag2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: C.129P2-Il2tm1Hor

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008578 decreased circulating interferon-gamma level "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: B6.129P2-Il2tm1Hor/J

 MP:0008603 decreased circulating interleukin-4 level "reduction in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: B6.129P2-Il2tm1Hor/J

 MP:0008609 decreased circulating interleukin-13 level "reduction in the amount in the blood of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: B6.129P2-Il2tm1Hor/J

 MP:0008614 increased circulating interleukin-17 level "increase in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2

 MP:0008615 decreased circulating interleukin-17 level "reduction in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6-Tcf7l2tm1a(EUCOMM)Wtsi

 MP:0008880 lacrimal gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the glands that secrete tears" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: B6.129P2-Il2tm1Hor/J

 MP:0009335 decreased splenocyte proliferation "reduction in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0009338 increased splenocyte number "increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: B6.129P2-Il2tm1Hor/J

 MP:0009517 abnormal salivary gland duct morphology "any structural anomaly of the tubular canals that carry saliva" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: B6.129P2-Il2tm1Hor/J

 MP:0010169 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: B6.129P2-Il2tm1Hor/J

 MP:0010210 abnormal circulating cytokine level "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: B6.129P2-Il2tm1Hor/J

 MP:0010219 increased T-helper 17 cell number "increased number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
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Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Rag2tm1Fwa/Rag2tm1Fwa,Tg(Tcra5CC7,Tcrb5CC7)IWep/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/10

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor
Genetic Background: B6.129P2-Il2tm1Hor/J

Allelic Composition: Il2tm1.1Kasm/Il2tm1.1Kasm,Ndor1Tg(UBC-cre/ERT2)1Ejb/?
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0013795 abnormal colon goblet cell morphology "any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the colon, whose primary function is to secrete gel-forming mucins, the major components of mucus" [MGI:Anna, PMID:25872481]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026770 Il2ra / P01590 / interleukin 2 receptor, alpha chain / P01589* / interleukin 2 receptor subunit alpha*  / complex / reaction
 ENSMUSG00000031304 Il2rg / P34902 / Cytokine receptor common subunit gamma / P31785* / AL590764.2* / interleukin 2 receptor subunit gamma*  / complex / reaction
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / complex / reaction
 ENSMUSG00000031805 Jak3 / Janus kinase 3 / P52333*  / complex / reaction
 ENSMUSG00000068227 Il2rb / P16297 / Interleukin-2 receptor subunit beta / P14784*  / complex / reaction
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex / reaction






 

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