ENSMUSG00000027737


Mus musculus

Features
Gene ID: ENSMUSG00000027737
  
Biological name :Slc7a11
  
Synonyms : Q9WTR6 / Slc7a11 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
  
Possible biological names infered from orthology : Q9UPY5 / solute carrier family 7 member 11
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: C
Gene start: 49892526
Gene end: 50443614
  
Corresponding Affymetrix probe sets: 10498024 (MoGene1.0st)   1420413_at (Mouse Genome 430 2.0 Array)   1443536_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029297
Ensembl peptide - ENSMUSP00000141988
NCBI entrez gene - 26570     See in Manteia.
MGI - MGI:1347355
RefSeq - XM_017319590
RefSeq - NM_011990
RefSeq - XM_006500776
RefSeq - XM_006500777
RefSeq - XM_006500778
RefSeq Peptide - NP_036120
swissprot - A0A0B4J1P7
swissprot - Q542C8
swissprot - Q9WTR6
Ensembl - ENSMUSG00000027737
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc7a11ENSDARG00000071384Danio rerio
 SLC7A11ENSGALG00000009758Gallus gallus
 Q9UPY5ENSG00000151012Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9Z127 / Slc7a5 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 / Q01650* / solute carrier family 7 member 5*ENSMUSG0000004001044
Q8BGK6 / Slc7a6 / Mus musculus solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 (Slc7a6), transcript variant 4, mRNA. / Q92536* / solute carrier family 7 member 6*ENSMUSG0000003190443
Q9Z1K8 / Slc7a7 / Y+L amino acid transporter 1 / Q9UM01* / solute carrier family 7 member 7*ENSMUSG0000000095842
P63115 / Slc7a10 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 10 / Q9NS82* / solute carrier family 7 member 10*ENSMUSG0000003049542
Q9QXW9 / Slc7a8 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 / Q9UHI5* / solute carrier family 7 member 8*ENSMUSG0000002218041
Q9QXA6 / Slc7a9 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 / P82251* / solute carrier family 7 member 9*ENSMUSG0000003049240
Slc7a15 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 15ENSMUSG0000002060035
Q91WN3 / Slc7a13 / Solute carrier family 7 member 13 / Q8TCU3*ENSMUSG0000004105229
Slc7a12 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 12ENSMUSG0000003971023


Protein motifs (from Interpro)
Interpro ID Name
 IPR002293  Amino acid/polyamine transporter I
 IPR004760  L-type amino acid transporter


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006865 amino acid transport IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0015813 L-glutamate transmembrane transport IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070306 lens fiber cell differentiation IEA
 biological_processGO:0070527 platelet aggregation IMP
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0015327 cystine:glutamate antiporter activity IBA
 molecular_functionGO:0022857 transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Basigin interactions
Amino acid transport across the plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bbs4Gt1Nk/Bbs4Gt1Nk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Agtpbp1m2Btlr/Agtpbp1m2Btlr
Genetic Background: C57BL/6J-Agtpbp1m2Btlr

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Agtpbp1m2Btlr/Agtpbp1m2Btlr
Genetic Background: C57BL/6J-Agtpbp1m2Btlr

 MP:0002699 abnormal vitreous body "anomalies of the transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc6a3tm1b(KOMP)Wtsi/Slc6a3+
Genetic Background: C57BL/6N-Slc6a3tm1b(KOMP)Wtsi/J

 MP:0003062 abnormal coping response "altered ability to respond productively to a stressful situation or stimulus, or failure to seek pleasurable stimuli" [RGD:Rat Genome Database submission]
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Allelic Composition: Slc6a3tm1b(KOMP)Wtsi/Slc6a3+
Genetic Background: C57BL/6N-Slc6a3tm1b(KOMP)Wtsi/J

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtpbp1m2Btlr/Agtpbp1m2Btlr
Genetic Background: C57BL/6J-Agtpbp1m2Btlr

 MP:0004725 decreased platelet serotonin level "reduced concentration of serotonin in the platelets; this biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
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Allelic Composition: Bbs4Gt1Nk/Bbs4Gt1Nk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Bbs4Gt1Nk/Bbs4Gt1Nk
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Slc7a11m1Mtka/Slc7a11m1Mtka
Genetic Background: C57BL/6-Slc7a11m1Mtka

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000010095 P10852 / Slc3a2 / solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 / P08195* / solute carrier family 3 member 2*  / complex






 

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