Manteia

ENSMUSG00000027867

Mus musculus

Features

Gene ID:	ENSMUSG00000027867

Biological name :	Spag17

Synonyms :	Q5S003 / Spag17 / Sperm-associated antigen 17

Possible biological names infered from orthology :	Q6Q759

Species:	Mus musculus

Chr. number:	3
Strand:	1
Band:	F2.2
Gene start:	99885406
Gene end:	100143322

Corresponding Affymetrix probe sets:	10494684 (MoGene1.0st) 1440472_at (Mouse Genome 430 2.0 Array) 1459142_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000134066 NCBI entrez gene - 74362 See in Manteia. MGI - MGI:1921612 RefSeq - NM_028892 RefSeq Peptide - NP_083168 swissprot - Q5S003 Ensembl - ENSMUSG00000027867

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
si:dkey-208b23.5	ENSDARG00000058280	Danio rerio
	ENSGALG00000043190	Gallus gallus
	ENSGALG00000035228	Gallus gallus
Q6Q759	ENSG00000155761	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR013783	Immunoglobulin-like fold
IPR026173	Sperm-associated antigen 17

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0003351	epithelial cilium movement	IMP
biological_process	GO:0030030	cell projection organization	IEA
biological_process	GO:1904158	axonemal central apparatus assembly	IMP
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005856	cytoskeleton	IEA
cellular_component	GO:0005874	microtubule	IEA
cellular_component	GO:0005929	cilium	IEA
cellular_component	GO:0031514	motile cilium	IEA
cellular_component	GO:0042995	cell projection	IEA
cellular_component	GO:1990716	axonemal central apparatus	IMP
molecular_function	GO:0005515	protein binding	IPI

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001177	atelectasis	"collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cacna1a^tm1.1Ehess/Cacna1a^tm1.1Ehess Genetic Background: C57BL/6-Cacna1a^tm1.1Ehess
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Cacna1a^tm1.1Ehess/Cacna1a^tm1.1Ehess Genetic Background: C57BL/6-Cacna1a^tm1.1Ehess
MP:0001436	abnormal suckling behavior	"reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]	Show Allelic Composition: Cacna1a^tm1.1Ehess/Cacna1a^tm1.1Ehess Genetic Background: C57BL/6-Cacna1a^tm1.1Ehess
MP:0001575	cyanosis	"a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]	Show Allelic Composition: Cacna1a^tm1.1Ehess/Cacna1a^tm1.1Ehess Genetic Background: C57BL/6-Cacna1a^tm1.1Ehess
MP:0001891	hydroencephaly	"excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Cacna1a^tm1.1Ehess/Cacna1a^tm1.1Ehess Genetic Background: C57BL/6-Cacna1a^tm1.1Ehess
MP:0001953	respiratory failure	"cessation of or failure to commence breathing" [MGI:cls, J:60159]	Show Allelic Composition: Cacna1a^tm1.1Ehess/Cacna1a^tm1.1Ehess Genetic Background: C57BL/6-Cacna1a^tm1.1Ehess
MP:0001954	respiratory distress	"physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Cacna1a^tm1.1Ehess/Cacna1a^tm1.1Ehess Genetic Background: C57BL/6-Cacna1a^tm1.1Ehess
MP:0003828	pulmonary edema	"an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Cacna1a^tm1.1Ehess/Cacna1a^tm1.1Ehess Genetic Background: C57BL/6-Cacna1a^tm1.1Ehess
MP:0005333	decreased heart rate	"fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]	Show Allelic Composition: Cacna1a^tm1.1Ehess/Cacna1a^tm1.1Ehess Genetic Background: C57BL/6-Cacna1a^tm1.1Ehess
MP:0008535	enlarged lateral ventricles	"increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cacna1a^tm1.1Ehess/Cacna1a^tm1.1Ehess Genetic Background: C57BL/6-Cacna1a^tm1.1Ehess
MP:0009546	absent gastric milk in neonates	"failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cacna1a^tm1.1Ehess/Cacna1a^tm1.1Ehess Genetic Background: C57BL/6-Cacna1a^tm1.1Ehess
MP:0010752	impaired mucociliary clearance	"reduced ability to remove mucus and other foreign particles and microorganisms from the lungs by directed ciliary movement and secretory activity of the tracheobronchial submucosal glands" [MESH:E01.370.386.520, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cacna1a^tm1.1Ehess/Cacna1a^tm1.1Ehess Genetic Background: C57BL/6-Cacna1a^tm1.1Ehess
MP:0010898	abnormal pulmonary alveolus epithelium morphology	"any structural anomaly of the epithelial layer of the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cacna1a^tm1.1Ehess/Cacna1a^tm1.1Ehess Genetic Background: C57BL/6-Cacna1a^tm1.1Ehess
MP:0011050	abnormal respiratory motile cilium morphology	"any structural anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cacna1a^tm1.1Ehess/Cacna1a^tm1.1Ehess Genetic Background: C57BL/6-Cacna1a^tm1.1Ehess
MP:0011055	abnormal respiratory motile cilium physiology	"any functional anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract; may include alterations in ciliary beating pattern or frequency" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cacna1a^tm1.1Ehess/Cacna1a^tm1.1Ehess Genetic Background: C57BL/6-Cacna1a^tm1.1Ehess
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Cacna1a^tm1.1Ehess/Cacna1a^tm1.1Ehess Genetic Background: C57BL/6-Cacna1a^tm1.1Ehess
MP:0011091	complete prenatal lethality	"death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Cacna1a^tm1.1Ehess/Cacna1a^tm1.1Ehess Genetic Background: C57BL/6-Cacna1a^tm1.1Ehess
MP:0011380	enlarged brain ventricle	"increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]	Show Allelic Composition: Cacna1a^tm1.1Ehess/Cacna1a^tm1.1Ehess Genetic Background: C57BL/6-Cacna1a^tm1.1Ehess
MP:0011649	immotile respiratory cilia	"failure of the multiple epithelial tiny, motile hair-like projections of the repiratory tract epithelium to beat with a characteristic whip-like pattern in order to promote transport of fluids and other cells across the epithelium of the respiratory tract" [MGI:csmith]	Show Allelic Composition: Cacna1a^tm1.1Ehess/Cacna1a^tm1.1Ehess Genetic Background: C57BL/6-Cacna1a^tm1.1Ehess

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr