ENSMUSG00000028071


Mus musculus

Features
Gene ID: ENSMUSG00000028071
  
Biological name :Sh2d2a
  
Synonyms : Q9QXK9 / Sh2d2a / SH2 domain containing 2A
  
Possible biological names infered from orthology : Q9NP31
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F1
Gene start: 87846755
Gene end: 87855722
  
Corresponding Affymetrix probe sets: 10493076 (MoGene1.0st)   1449105_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029709
Ensembl peptide - ENSMUSP00000103207
NCBI entrez gene - 27371     See in Manteia.
MGI - MGI:1351596
RefSeq - XM_017319606
RefSeq - NM_001025571
RefSeq - NM_021309
RefSeq - XM_006501554
RefSeq - XM_006501555
RefSeq - XM_006501556
RefSeq Peptide - NP_001020742
RefSeq Peptide - NP_067284
swissprot - Q5D0E4
swissprot - Q9QXK9
Ensembl - ENSMUSG00000028071
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch73-109i22.2ENSDARG00000089983Danio rerio
 ENSGALG00000044505Gallus gallus
 Q9NP31ENSG00000027869Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hsh2d / Q6VYH9 / Hematopoietic SH2 domain-containing protein / Q96JZ2* / hematopoietic SH2 domain containing*ENSMUSG0000006200717
A6X942 / Sh2d4b / SH2 domain-containing protein 4B / Q5SQS7* / SH2 domain containing 4B*ENSMUSG0000003783315
Q9D7V1 / Sh2d4a / SH2 domain-containing protein 4A / Q9H788* / SH2 domain containing 4A*ENSMUSG0000005388615
Sh2d7 / Q8BI17 / SH2 domain-containing protein 7 ENSMUSG000000464607


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR035884  SH2D2A, SH2 domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0009967 positive regulation of signal transduction IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017124 SH3 domain binding IEA


Pathways (from Reactome)
Pathway description
VEGFA-VEGFR2 Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Sp4tm1Krc/Sp4tm1Krc
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Sp4tm1Krc/Sp4tm1Krc
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Sp4tm1Krc/Sp4tm1Krc
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Sp4tm1Krc/Sp4tm1Krc
Genetic Background: involves: 129S4/SvJae * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002602 Axl / Q00993 / AXL receptor tyrosine kinase / P30530*  / complex / reaction
 ENSMUSG00000023951 Vegfa / Q00731 / vascular endothelial growth factor A / P15692*  / complex / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / complex / reaction
 ENSMUSG00000062960 Kdr / kinase insert domain receptor / P35968*  / complex / reaction






 

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