ENSMUSG00000028109


Mus musculus

Features
Gene ID: ENSMUSG00000028109
  
Biological name :Hormad1
  
Synonyms : Hormad1 / HORMA domain-containing protein 1 / Q9D5T7
  
Possible biological names infered from orthology : HORMA domain containing 1 / Q86X24
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.1
Gene start: 95559677
Gene end: 95587671
  
Corresponding Affymetrix probe sets: 10494281 (MoGene1.0st)   10536427 (MoGene1.0st)   1450292_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029754
Ensembl peptide - ENSMUSP00000088303
Ensembl peptide - ENSMUSP00000102772
Ensembl peptide - ENSMUSP00000127180
NCBI entrez gene - 67981     See in Manteia.
MGI - MGI:1915231
RefSeq - XM_006501955
RefSeq - NM_001289532
RefSeq - NM_001289534
RefSeq - NM_001289537
RefSeq - NM_026489
RefSeq - XM_006501954
RefSeq Peptide - NP_001276466
RefSeq Peptide - NP_080765
RefSeq Peptide - NP_001276461
RefSeq Peptide - NP_001276463
swissprot - Q9D5T7
Ensembl - ENSMUSG00000028109
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A2BF66ENSDARG00000040254Danio rerio
 HORMAD1ENSGALG00000043021Gallus gallus
 Q86X24ENSG00000143452Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q5SQP1 / Hormad2 / HORMA domain-containing protein 2 / Q8N7B1* / HORMA domain containing 2*ENSMUSG0000002041937


Protein motifs (from Interpro)
Interpro ID Name
 IPR003511  HORMA domain
 IPR036570  HORMA domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001824 blastocyst development IMP
 biological_processGO:0007129 synapsis IMP
 biological_processGO:0007130 synaptonemal complex assembly IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0042138 meiotic DNA double-strand break formation IMP
 biological_processGO:0048477 oogenesis IMP
 biological_processGO:0051177 meiotic sister chromatid cohesion IMP
 biological_processGO:0051321 meiotic cell cycle IEP
 biological_processGO:0051598 meiotic recombination checkpoint IMP
 biological_processGO:0060629 regulation of homologous chromosome segregation IMP
 cellular_componentGO:0000794 condensed nuclear chromosome IDA
 cellular_componentGO:0000795 synaptonemal complex IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ucp2tm2.1Lowl/Ucp2tm2.1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/NJ

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Ucp2tm2.1Lowl/Ucp2tm2.1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/NJ

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Ucp2tm2.1Lowl/Ucp2tm2.1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/NJ

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Leprdb/Leprdb,Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BLKS/J * DBA

Allelic Composition: Hormad1tm1.2Atot/Hormad1tm1.2Atot
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * SJL

 MP:0001728 failure of implantation "inability of the blastocyst to attach to the endometrium of the uterus" [J:38772]
Show

Allelic Composition: Ucp2tm2.1Lowl/Ucp2tm2.1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/NJ

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Ucp2tm2.1Lowl/Ucp2tm2.1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/NJ

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ucp2tm2.1Lowl/Ucp2tm2.1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/NJ

Allelic Composition: Hormad1tm1Atot/Hormad1tm1Atot
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd

Allelic Composition: Hormad1tm1.2Atot/Hormad1tm1.2Atot
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * SJL

Allelic Composition: Hormad1tm1Kura/Hormad1tm1Kura
Genetic Background: either: B6.Cg-Hormad1tm1Kura or (involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj)

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Ucp2tm2.1Lowl/Ucp2tm2.1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/NJ

Allelic Composition: Hormad1tm1Atot/Hormad1tm1Atot
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd

Allelic Composition: Hormad1tm1.2Atot/Hormad1tm1.2Atot
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * SJL

 MP:0001930 abnormal meiosis "malfunction in the process of nuclear division that results in gametes with one half the normal number of the original cell" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ucp2tm2.1Lowl/Ucp2tm2.1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/NJ

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hormad1tm1Kura/Hormad1tm1Kura
Genetic Background: either: B6.Cg-Hormad1tm1Kura or (involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj)

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ucp2tm2.1Lowl/Ucp2tm2.1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/NJ

Allelic Composition: Hormad1tm1Kura/Hormad1tm1Kura
Genetic Background: either: B6.Cg-Hormad1tm1Kura or (involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj)

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ucp2tm2.1Lowl/Ucp2tm2.1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/NJ

Allelic Composition: Hormad1tm1Kura/Hormad1tm1Kura
Genetic Background: either: B6.Cg-Hormad1tm1Kura or (involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj)

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ucp2tm2.1Lowl/Ucp2tm2.1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/NJ

Allelic Composition: Hormad1tm1Atot/Hormad1tm1Atot
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd

Allelic Composition: Hormad1tm1.2Atot/Hormad1tm1.2Atot
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * SJL

Allelic Composition: Hormad1tm1Kura/Hormad1tm1Kura
Genetic Background: either: B6.Cg-Hormad1tm1Kura or (involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj)

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ucp2tm2.1Lowl/Ucp2tm2.1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/NJ

Allelic Composition: Hormad1tm1Atot/Hormad1tm1Atot
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd

Allelic Composition: Hormad1tm1Atot/Hormad1tm1Atot,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd

Allelic Composition: Hormad1tm1.2Atot/Hormad1tm1.2Atot
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * SJL

Allelic Composition: Hormad1tm1.2Atot/Hormad1tm1.2Atot,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * SJL

Allelic Composition: Hormad1tm1Kura/Hormad1tm1Kura
Genetic Background: either: B6.Cg-Hormad1tm1Kura or (involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj)

Allelic Composition: Hormad1tm1Kura/Hormad1tm1Kura,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hormad1tm1Atot/Hormad1tm1Atot
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd

Allelic Composition: Hormad1tm1Atot/Hormad1tm1Atot,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd

Allelic Composition: Hormad1tm1.2Atot/Hormad1tm1.2Atot
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * SJL

Allelic Composition: Hormad1tm1.2Atot/Hormad1tm1.2Atot,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * SJL

Allelic Composition: Hormad1tm1Kura/Hormad1tm1Kura
Genetic Background: either: B6.Cg-Hormad1tm1Kura or (involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj)

Allelic Composition: Hormad1tm1Kura/Hormad1tm1Kura,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: Hormad1tm1Kura/Hormad1tm1Kura
Genetic Background: either: B6.Cg-Hormad1tm1Kura or (involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj)

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ucp2tm2.1Lowl/Ucp2tm2.1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/NJ

Allelic Composition: Hormad1tm1Kura/Hormad1tm1Kura
Genetic Background: either: B6.Cg-Hormad1tm1Kura or (involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj)

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ucp2tm2.1Lowl/Ucp2tm2.1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/NJ

Allelic Composition: Hormad1tm1Atot/Hormad1tm1Atot
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd

Allelic Composition: Hormad1tm1.2Atot/Hormad1tm1.2Atot
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * SJL

Allelic Composition: Hormad1tm1Kura/Hormad1tm1Kura
Genetic Background: either: B6.Cg-Hormad1tm1Kura or (involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj)

Allelic Composition: Hormad1tm1Kura/Hormad1tm1Kura,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008966 abnormal chiasmata formation "atypical contact between nonsister chromatids of homologous chromosomes during meiosis I, precluding formation of the expected number of cross-shaped configurations representing recombination events" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ucp2tm2.1Lowl/Ucp2tm2.1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/NJ

Allelic Composition: Hormad1tm1Atot/Hormad1tm1Atot
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd

Allelic Composition: Hormad1tm1.2Atot/Hormad1tm1.2Atot
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * SJL

 MP:0009451 abnormal chromosome pairing during meiosis "an anomaly in the highly specific side-by-side association of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ucp2tm2.1Lowl/Ucp2tm2.1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/NJ

Allelic Composition: Hormad1tm1Kura/Hormad1tm1Kura
Genetic Background: either: B6.Cg-Hormad1tm1Kura or (involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj)

 MP:0009452 abnormal synaptonemal complex "an anomaly in the formation of the proteinaceous structure involved in the pairing of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hormad1tm1Atot/Hormad1tm1Atot
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd

Allelic Composition: Hormad1tm1Atot/Hormad1tm1Atot,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd

Allelic Composition: Hormad1tm1.2Atot/Hormad1tm1.2Atot
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * SJL

Allelic Composition: Hormad1tm1.2Atot/Hormad1tm1.2Atot,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * SJL

 MP:0009781 abnormal preimplantation embryo development "an anomaly in the developmental progress of an embryo from 2 cell to blastocyst affecting the viability or number of embryos" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ucp2tm2.1Lowl/Ucp2tm2.1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/NJ

 MP:0010767 abnormal female meiosis I arrest "any anomaly in the process in which oocytes stop at the diplotene stage of meiosis I and lie dormant, often for long periods of time" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ucp2tm2.1Lowl/Ucp2tm2.1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/NJ

 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
Show

Allelic Composition: Hormad1tm1Atot/Hormad1tm1Atot
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd

Allelic Composition: Dmc1tm1Jcs/Dmc1tm1Jcs,Hormad1tm1Atot/Hormad1tm1Atot
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Hormad1tm1.2Atot/Hormad1tm1.2Atot
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * SJL

Allelic Composition: Dmc1tm1Jcs/Dmc1tm1Jcs,Hormad1tm1.2Atot/Hormad1tm1.2Atot
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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