ENSMUSG00000028156


Mus musculus

Features
Gene ID: ENSMUSG00000028156
  
Biological name :Eif4e
  
Synonyms : Eif4e / Eukaryotic translation initiation factor 4E / P63073
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G3
Gene start: 138526179
Gene end: 138559696
  
Corresponding Affymetrix probe sets: 10496485 (MoGene1.0st)   10496490 (MoGene1.0st)   10599855 (MoGene1.0st)   1423220_at (Mouse Genome 430 2.0 Array)   1444010_at (Mouse Genome 430 2.0 Array)   1450908_at (Mouse Genome 430 2.0 Array)   1450909_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029803
Ensembl peptide - ENSMUSP00000143772
Ensembl peptide - ENSMUSP00000143690
Ensembl peptide - ENSMUSP00000143481
Ensembl peptide - ENSMUSP00000143104
NCBI entrez gene - 13684     See in Manteia.
MGI - MGI:95305
RefSeq - XM_017319453
RefSeq - NM_001313980
RefSeq - NM_007917
RefSeq - XM_006500993
RefSeq Peptide - NP_001300909
RefSeq Peptide - NP_031943
swissprot - P63073
swissprot - A0A0G2JG98
swissprot - A0A0G2JFB4
swissprot - Q3TK95
swissprot - A0A0G2JGT5
swissprot - A0A0G2JH04
Ensembl - ENSMUSG00000028156
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif4eaENSDARG00000077012Danio rerio
 eif4ebENSDARG00000013274Danio rerio
 EIF4EENSGALG00000042112Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3UTA9 / Eif4e1b / Eukaryotic translation initiation factor 4E type 1B / A6NMX2* / eukaryotic translation initiation factor 4E family member 1B*ENSMUSG0000007489556
Eif4e2 / Q8BMB3 / Mus musculus eukaryotic translation initiation factor 4E member 2 (Eif4e2), transcript variant 4, mRNA. / O60573* / eukaryotic translation initiation factor 4E family member 2*ENSMUSG0000002625434
Eif4e3 / Q9DBB5 / Eukaryotic translation initiation factor 4E type 3 / Q8N5X7* / eukaryotic translation initiation factor 4E family member 3*ENSMUSG0000009366125


Protein motifs (from Interpro)
Interpro ID Name
 IPR001040  Translation Initiation factor eIF- 4e
 IPR019770  Eukaryotic translation initiation factor 4E (eIF-4E), conserved site
 IPR023398  Translation Initiation factor eIF- 4e-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle ISO
 biological_processGO:0001662 behavioral fear response IGI
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation IEA
 biological_processGO:0006417 regulation of translation ISO
 biological_processGO:0017148 negative regulation of translation IMP
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0030324 lung development IEA
 biological_processGO:0045665 negative regulation of neuron differentiation IMP
 biological_processGO:0045931 positive regulation of mitotic cell cycle ISO
 biological_processGO:0071549 cellular response to dexamethasone stimulus IDA
 cellular_componentGO:0000932 P-body ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005845 mRNA cap binding complex IDA
 cellular_componentGO:0010494 cytoplasmic stress granule ISS
 cellular_componentGO:0016281 eukaryotic translation initiation factor 4F complex IEA
 cellular_componentGO:0016442 RISC complex ISO
 cellular_componentGO:0033391 chromatoid body IDA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 molecular_functionGO:0000340 RNA 7-methylguanosine cap binding ISO
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003743 translation initiation factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding ISS
 molecular_functionGO:0031370 eukaryotic initiation factor 4G binding IEA
 molecular_functionGO:0070491 repressing transcription factor binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Eif4etm1.1Lfur/Eif4etm1.1Lfur,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Sox17tm1.1Nat/Sox17tm1.1Nat
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Eif4eGt(RRO036)Byg/Eif4e+,Krastm3Tyj/Kras+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk5rap2Gt(RRU031)Byg/Cdk5rap2Gt(RRU031)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008412 increased cellular sensitivity to oxidative stress "greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Eif4eGt(RRO036)Byg/Eif4e+,Krastm3Tyj/Kras+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N

 MP:0010267 decreased lung tumor incidence "less than the expected number of neoplams in the lung, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Eif4eGt(RRO036)Byg/Eif4e+,Krastm3Tyj/Kras+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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