ENSMUSG00000028222


Mus musculus

Features
Gene ID: ENSMUSG00000028222
  
Biological name :Calb1
  
Synonyms : Calb1 / Calbindin / P12658
  
Possible biological names infered from orthology : calbindin 1 / P05937
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: A2
Gene start: 15881264
Gene end: 15908064
  
Corresponding Affymetrix probe sets: 10503416 (MoGene1.0st)   1417504_at (Mouse Genome 430 2.0 Array)   1448738_at (Mouse Genome 430 2.0 Array)   1456934_at (Mouse Genome 430 2.0 Array)   1458836_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029876
NCBI entrez gene - 12307     See in Manteia.
MGI - MGI:88248
RefSeq - NM_009788
RefSeq Peptide - NP_033918
swissprot - P12658
Ensembl - ENSMUSG00000028222
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 calb1ENSDARG00000031598Danio rerio
 CALB1ENSGALG00000032282Gallus gallus
 CALB1ENSG00000104327Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Calb2 / Q08331 / Calretinin / P22676* / calbindin 2*ENSMUSG0000000365759
Scgn / Q91WD9 / Secretagogin / O76038* / secretagogin, EF-hand calcium binding protein*ENSMUSG0000002133734


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR029634  Calbindin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0007614 short-term memory IEA
 biological_processGO:0007616 long-term memory IEA
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0010842 retina layer formation IEP
 biological_processGO:0035502 metanephric part of ureteric bud development IEP
 biological_processGO:0048167 regulation of synaptic plasticity IEA
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0055074 calcium ion homeostasis IEA
 biological_processGO:0060041 retina development in camera-type eye IEP
 biological_processGO:0071310 cellular response to organic substance IDA
 biological_processGO:0072205 metanephric collecting duct development IEP
 biological_processGO:0072221 metanephric distal convoluted tubule development IEP
 biological_processGO:0072286 metanephric connecting tubule development IEP
 biological_processGO:0099509 regulation of presynaptic cytosolic calcium ion concentration IEA
 biological_processGO:0099566 regulation of postsynaptic cytosolic calcium ion concentration IEA
 biological_processGO:1900271 regulation of long-term synaptic potentiation IMP
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0044297 cell body IDA
 cellular_componentGO:0045202 synapse IDA
 molecular_functionGO:0005499 vitamin D binding IEA
 molecular_functionGO:0005509 calcium ion binding IDA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0099567 calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration IC


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Anapc2tm1Kna/Anapc2tm1Kna,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Calb1tm1Mpin/Calb1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
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Allelic Composition: Mogat2tm1Far/Mogat2+
Genetic Background: B6.129S4-Mogat2tm1Far

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mogat2tm1Far/Mogat2+
Genetic Background: B6.129S4-Mogat2tm1Far

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Avptm1.1(cre)Hze/Avp+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Anapc2tm1Kna/Anapc2tm1Kna,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Calb1tm1Mpin/Calb1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Mogat2tm1Far/Mogat2+
Genetic Background: B6.129S4-Mogat2tm1Far

 MP:0004844 abnormal vestibuloocular reflex "any anomaly in the nystagmus or deviation of the eyes in response to stimulation of the vestibular system in which impulses are conveyed from the semicircular canals and the otolithic membrane to the oculomotor nerve; this stimulation may occur by angular acceleration or deceleration or by irrigation of the ear with hot or cold water; normally, this reflex functions to maintain a stable retinal image during head rotation by generating appropriate compensatory eye movements" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mogat2tm1Far/Mogat2+
Genetic Background: B6.129S4-Mogat2tm1Far

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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