ENSMUSG00000028369


Mus musculus

Features
Gene ID: ENSMUSG00000028369
  
Biological name :Svep1
  
Synonyms : A2AVA0 / Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 / Svep1
  
Possible biological names infered from orthology : Q4LDE5 / sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: B3
Gene start: 58042442
Gene end: 58206859
  
Corresponding Affymetrix probe sets: 10513208 (MoGene1.0st)   1419182_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000045856
NCBI entrez gene - 64817     See in Manteia.
MGI - MGI:1928849
RefSeq - NM_022814
RefSeq Peptide - NP_073725
swissprot - A2AVA0
Ensembl - ENSMUSG00000028369
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 svep1ENSDARG00000013526Danio rerio
 SVEP1ENSGALG00000015721Gallus gallus
 SVEP1ENSG00000165124Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Csmd3 / Q80T79 / CUB and sushi domain-containing protein 3 / Q7Z407* / CUB and Sushi multiple domains 3*ENSMUSG0000002231122
Csmd2 / CUB and Sushi multiple domains 2 / Q7Z408*ENSMUSG0000002880422
Csmd1 / Q923L3 / CUB and sushi domain-containing protein 1 / CUB and Sushi multiple domains 1*ENSMUSG0000006092422
Cr2 / complement C3d receptor 2 / P20023*ENSMUSG000000266167
Sez6 / Q7TSK2 / Seizure protein 6 / Q53EL9* / seizure related 6 homolog*ENSMUSG000000006325
Q4V9Z5 / Sez6l2 / Seizure 6-like protein 2 / Q6UXD5* / seizure related 6 homolog like 2*ENSMUSG000000306835
Sez6l / Q6P1D5 / seizure related 6 homolog like / Q9BYH1*ENSMUSG000000581535
Cr1l / Q64735 / Mus musculus complement component (3b/4b) receptor 1-like (Cr1l), transcript variant 2, mRNA. / Q2VPA4* / complement C3b/C4b receptor 1 like*ENSMUSG000000164812


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000436  Sushi/SCR/CCP domain
 IPR000742  EGF-like domain
 IPR001759  Pentraxin-related
 IPR001881  EGF-like calcium-binding domain
 IPR002035  von Willebrand factor, type A
 IPR003410  HYR domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR018097  EGF-like calcium-binding, conserved site
 IPR035976  Sushi/SCR/CCP superfamily
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0008150 biological_process ND
 cellular_componentGO:0005576 extracellular region ISS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Svep1tm1b(EUCOMM)Hmgu/Svep1tm1b(EUCOMM)Hmgu
Genetic Background: B6N(Cg)-Svep1tm1b(EUCOMM)Hmgu/J

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

Allelic Composition: Svep1tm1b(EUCOMM)Hmgu/Svep1tm1b(EUCOMM)Hmgu
Genetic Background: B6N(Cg)-Svep1tm1b(EUCOMM)Hmgu/J

 MP:0001874 acanthosis "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Svep1tm1b(EUCOMM)Hmgu/Svep1tm1b(EUCOMM)Hmgu
Genetic Background: B6N(Cg)-Svep1tm1b(EUCOMM)Hmgu/J

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

Allelic Composition: Svep1tm1b(EUCOMM)Hmgu/Svep1tm1b(EUCOMM)Hmgu
Genetic Background: B6N(Cg)-Svep1tm1b(EUCOMM)Hmgu/J

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

Allelic Composition: Svep1tm1b(EUCOMM)Hmgu/Svep1tm1b(EUCOMM)Hmgu
Genetic Background: B6N(Cg)-Svep1tm1b(EUCOMM)Hmgu/J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0009931 abnormal skin appearance "skin that looks different from the usual state" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

Allelic Composition: Svep1tm1b(EUCOMM)Hmgu/Svep1tm1b(EUCOMM)Hmgu
Genetic Background: B6N(Cg)-Svep1tm1b(EUCOMM)Hmgu/J

 MP:0011239 abnormal skin coloration "a variation in an expected skin color or complexion that may be due to inflammation, pigment defects or other causes" [MGI:llw2]
Show

Allelic Composition: Svep1tm1b(EUCOMM)Hmgu/Svep1tm1b(EUCOMM)Hmgu
Genetic Background: B6N(Cg)-Svep1tm1b(EUCOMM)Hmgu/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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