ENSMUSG00000028386


Mus musculus

Features
Gene ID: ENSMUSG00000028386
  
Biological name :Slc46a2
  
Synonyms : Q8CA03 / Slc46a2 / solute carrier family 46, member 2
  
Possible biological names infered from orthology : Q9BY10
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: B3
Gene start: 59905126
Gene end: 59915056
  
Corresponding Affymetrix probe sets: 10513406 (MoGene1.0st)   1423476_at (Mouse Genome 430 2.0 Array)   1456297_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030081
NCBI entrez gene - 30936     See in Manteia.
MGI - MGI:1353616
RefSeq - NM_021053
RefSeq Peptide - NP_066395
swissprot - Q8CA03
Ensembl - ENSMUSG00000028386
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc46a2ENSDARG00000075229Danio rerio
 SLC46A2ENSGALG00000027345Gallus gallus
 Q9BY10ENSG00000119457Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9DC26 / Slc46a3 / Solute carrier family 46 member 3 / Q7Z3Q1*ENSMUSG0000002965023
Q6PEM8 / Slc46a1 / solute carrier family 46, member 1 / Q96NT5*ENSMUSG0000002082922


Protein motifs (from Interpro)
Interpro ID Name
 IPR001958  Tetracycline resistance protein TetA/multidrug resistance protein MdtG
 IPR011701  Major facilitator superfamily
 IPR020846  Major facilitator superfamily domain
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0043029 T cell homeostasis IGI
 biological_processGO:0045580 regulation of T cell differentiation IGI
 biological_processGO:0048538 thymus development IGI
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070233 negative regulation of T cell apoptotic process IGI
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005215 transporter activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Nlrp5tm1Zbt/Nlrp5tm1Zbt,OoepGt(139A2)Cmhd/OoepGt(139A2)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Slc46a2tm1Moki/Slc46a2+,Tg(TcraB12,TcrbB12)1Rest/0
Genetic Background: involves: 129 * C57BL/6

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Slc46a2tm1Moki/Slc46a2+,Tg(TcraB12,TcrbB12)1Rest/0
Genetic Background: involves: 129 * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Slc46a2tm1Moki/Slc46a2+,Tg(TcraB12,TcrbB12)1Rest/0
Genetic Background: involves: 129 * C57BL/6

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Slc46a2tm1Moki/Slc46a2+,Tg(TcraB12,TcrbB12)1Rest/0
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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