ENSMUSG00000028445


Mus musculus

Features
Gene ID: ENSMUSG00000028445
  
Biological name :Enho
  
Synonyms : Adropin / Enho / Q8K1D8
  
Possible biological names infered from orthology : energy homeostasis associated / Q6UWT2
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: A5
Gene start: 41638144
Gene end: 41640324
  
Corresponding Affymetrix probe sets: 10512274 (MoGene1.0st)   1428739_at (Mouse Genome 430 2.0 Array)   1433382_at (Mouse Genome 430 2.0 Array)   1452893_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000137902
NCBI entrez gene - 69638     See in Manteia.
MGI - MGI:1916888
RefSeq - NM_027147
RefSeq Peptide - NP_081423
swissprot - Q8K1D8
Ensembl - ENSMUSG00000028445
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENHOENSG00000168913Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR034461  Adropin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0045747 positive regulation of Notch signaling pathway IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Malt1m3Btlr/Malt1+
Genetic Background: C57BL/6J-Malt1m3Btlr

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Rassf1tm1Gpp/Rassf1tm1Gpp,Sav1tm1.1Gpp/Sav1+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Malt1m3Btlr/Malt1+
Genetic Background: C57BL/6J-Malt1m3Btlr

Allelic Composition: Enhotm1.1Butl/Enhotm1.1Butl
Genetic Background: B6.Cg-Enhotm1.1Butl

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Malt1m3Btlr/Malt1+
Genetic Background: C57BL/6J-Malt1m3Btlr

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Enhotm1.1Butl/Enhotm1.1Butl
Genetic Background: B6.Cg-Enhotm1.1Butl

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Enhotm1.1Butl/Enhotm1.1Butl
Genetic Background: B6.Cg-Enhotm1.1Butl

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Enhotm1.1Butl/Enhotm1.1Butl
Genetic Background: B6.Cg-Enhotm1.1Butl

Allelic Composition: Enhotm1.1Butl/Enho+
Genetic Background: B6.Cg-Enhotm1.1Butl

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Malt1m3Btlr/Malt1+
Genetic Background: C57BL/6J-Malt1m3Btlr

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Enhotm1.1Butl/Enhotm1.1Butl
Genetic Background: B6.Cg-Enhotm1.1Butl

Allelic Composition: Enhotm1.1Butl/Enho+
Genetic Background: B6.Cg-Enhotm1.1Butl

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Enhotm1.1Butl/Enhotm1.1Butl
Genetic Background: B6.Cg-Enhotm1.1Butl

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Enhotm1.1Butl/Enhotm1.1Butl
Genetic Background: B6.Cg-Enhotm1.1Butl

Allelic Composition: Enhotm1.1Butl/Enho+
Genetic Background: B6.Cg-Enhotm1.1Butl

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Enhotm1.1Butl/Enhotm1.1Butl
Genetic Background: B6.Cg-Enhotm1.1Butl

Allelic Composition: Enhotm1.1Butl/Enho+
Genetic Background: B6.Cg-Enhotm1.1Butl

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Enhotm1.1Butl/Enhotm1.1Butl
Genetic Background: B6.Cg-Enhotm1.1Butl

Allelic Composition: Enhotm1.1Butl/Enho+
Genetic Background: B6.Cg-Enhotm1.1Butl

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Malt1m3Btlr/Malt1+
Genetic Background: C57BL/6J-Malt1m3Btlr

 MP:0013245 abnormal lipid metabolism "any anomaly in the chemical reactions and pathways involving a lipid, including metabolic, catabolic and biosynthetic processes" [MPD:Molly]
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Allelic Composition: Enhotm1.1Butl/Enhotm1.1Butl
Genetic Background: B6.Cg-Enhotm1.1Butl

Allelic Composition: Enhotm1.1Butl/Enho+
Genetic Background: B6.Cg-Enhotm1.1Butl

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Enhotm1.1Butl/Enhotm1.1Butl
Genetic Background: B6.Cg-Enhotm1.1Butl

 MP:0014142 increased body fat mass "increased physical bulk or volume of fat in the whole body" [MGI:csmith]
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Allelic Composition: Enhotm1.1Butl/Enhotm1.1Butl
Genetic Background: B6.Cg-Enhotm1.1Butl

 MP:0030022 decreased muscle cell glucose uptake "reduced ability of muscle cells to take in glucose" [MGI:anna]
Show

Allelic Composition: Enhotm1.1Butl/Enhotm1.1Butl
Genetic Background: B6.Cg-Enhotm1.1Butl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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