ENSMUSG00000028572


Mus musculus

Features
Gene ID: ENSMUSG00000028572
  
Biological name :Hook1
  
Synonyms : 1 / Hook1 / Q8BIL5
  
Possible biological names infered from orthology : hook microtubule tethering protein 1 / Q9UJC3
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C5
Gene start: 95967240
Gene end: 96025413
  
Corresponding Affymetrix probe sets: 10506004 (MoGene1.0st)   1438018_at (Mouse Genome 430 2.0 Array)   1439173_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030306
Ensembl peptide - ENSMUSP00000102698
NCBI entrez gene - 77963     See in Manteia.
MGI - MGI:1925213
RefSeq - XM_006503488
RefSeq - NM_030014
RefSeq - XM_006503487
RefSeq Peptide - NP_084290
swissprot - Q8BJ23
swissprot - Q8BIL5
Ensembl - ENSMUSG00000028572
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hook1ENSDARG00000042946Danio rerio
 HOOK1ENSGALG00000010889Gallus gallus
 HOOK1ENSG00000134709Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
3 / Hook3 / Q8BUK6 / Q86VS8* / hook microtubule tethering protein 3*ENSMUSG0000003723456
2 / Hook2 / Q7TMK6 / Q96ED9* / hook microtubule tethering protein 2*ENSMUSG0000005256644
Q6VGS5 / Ccdc88c / Protein Daple / Q9P219* / coiled-coil domain containing 88C*ENSMUSG0000002118224
Q5SNZ0 / Ccdc88a / Girdin / Q3V6T2* / coiled-coil domain containing 88A*ENSMUSG0000003274024
Q4QRL3 / Ccdc88b / Coiled-coil domain-containing protein 88B / A6NC98* / coiled-coil domain containing 88B*ENSMUSG0000004781020


Protein motifs (from Interpro)
Interpro ID Name
 IPR008636  Hook-like protein family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007032 endosome organization IEA
 biological_processGO:0007040 lysosome organization IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0008333 endosome to lysosome transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030705 cytoskeleton-dependent intracellular transport IBA
 biological_processGO:0031122 cytoplasmic microtubule organization IBA
 biological_processGO:0045022 early endosome to late endosome transport IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005813 centrosome IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0030897 HOPS complex IEA
 cellular_componentGO:0070695 FHF complex IEA
 molecular_functionGO:0003779 actin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding ISO
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0051959 dynein light intermediate chain binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Dac,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Dac,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Dac,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Dac,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Dac,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Dac,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Dac,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB

 MP:0008545 absent sperm flagella "mature spermatozoa lack a flagella" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Dac,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB

 MP:0008893 detached sperm flagellum "fragmentation of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility from the sperm head" [MESH:A05.360.490.890.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Dac,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB

 MP:0009232 abnormal sperm nucleus morphology "any structural abnormality of the sperm head nucleus, including an abnormal nuclear shape or defects in the compaction of nuclear chromatin" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Dac,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB

 MP:0009376 abnormal manchette morphology "any structural abnormality of the conic array of microtubules that invests the posterior nucleus of a spermatid, and is believed to play a role in definitive posterior head-shaping events during spermiogenesis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Dac,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB

 MP:0009377 ectopic manchette "abnormal position of the conic array of microtubules that normally invests the posterior nucleus of a spermatid" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Dac,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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