ENSMUSG00000028602


Mus musculus

Features
Gene ID: ENSMUSG00000028602
  
Biological name :Tnfrsf8
  
Synonyms : Q60846 / Tnfrsf8 / Tumor necrosis factor receptor superfamily member 8
  
Possible biological names infered from orthology : P28908 / TNF receptor superfamily member 8
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E1
Gene start: 145267137
Gene end: 145315164
  
Corresponding Affymetrix probe sets: 10518313 (MoGene1.0st)   1421649_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030339
Ensembl peptide - ENSMUSP00000118714
NCBI entrez gene - 21941     See in Manteia.
MGI - MGI:99908
RefSeq - NM_009401
RefSeq Peptide - NP_033427
swissprot - D6RHK4
swissprot - A1L3C9
swissprot - Q60846
Ensembl - ENSMUSG00000028602
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TNFRSF8ENSGALG00000039741Gallus gallus
 P28908ENSG00000120949Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR020416  Tumour necrosis factor receptor 8
 IPR034002  Tumour necrosis factor receptor 8, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007411 axon guidance IBA
 biological_processGO:0010977 negative regulation of neuron projection development IBA
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042535 positive regulation of tumor necrosis factor biosynthetic process ISO
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0045556 positive regulation of TRAIL biosynthetic process ISO
 biological_processGO:0097190 apoptotic signaling pathway IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043005 neuron projection IBA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005031 tumor necrosis factor-activated receptor activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0048406 nerve growth factor binding IBA


Pathways (from Reactome)
Pathway description
TNFs bind their physiological receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
Show

Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd2tm1Wbg/Ccnd2tm1Wbg
Genetic Background: Not Specified

 MP:0000714 increased thymocyte number "greater than expected number of precursors to T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd2tm1Wbg/Ccnd2tm1Wbg
Genetic Background: Not Specified

 MP:0005673 decreased susceptibility to graft versus host disease "less likelihood of developing clinical symptoms of anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the a graft versus host reaction, which is an immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
Show

Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028362 P32972 / Tnfsf8 / tumor necrosis factor (ligand) superfamily, member 8 / P32971* / TNF superfamily member 8*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr