ENSMUSG00000028610


Mus musculus

Features
Gene ID: ENSMUSG00000028610
  
Biological name :Dmrtb1
  
Synonyms : A2A9I7 / Dmrtb1 / Doublesex- and mab-3-related transcription factor B1
  
Possible biological names infered from orthology : DMRT like family B with proline rich C-terminal 1 / Q96MA1
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C7
Gene start: 107676290
Gene end: 107684230
  
Corresponding Affymetrix probe sets: 10514919 (MoGene1.0st)   1427252_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000064220
Ensembl peptide - ENSMUSP00000119617
NCBI entrez gene - 56296     See in Manteia.
MGI - MGI:1927125
RefSeq - NM_019872
RefSeq - XM_006503252
RefSeq Peptide - NP_063925
swissprot - B1ASP8
swissprot - A2A9I7
Ensembl - ENSMUSG00000028610
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DMRTB1ENSGALG00000029023Gallus gallus
 DMRTB1ENSG00000143006Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dmrt1 / Q9QZ59 / Doublesex- and mab-3-related transcription factor 1 / Q9Y5R6*ENSMUSG0000002483719
Dmrt3 / Q80WT2 / Doublesex- and mab-3-related transcription factor 3 / Q9NQL9*ENSMUSG0000004237219
A2A9A2 / Dmrta2 / Doublesex- and mab-3-related transcription factor A2 / Q96SC8* / DMRT like family A2*ENSMUSG0000004714319
Dmrtc2 / Q8CGW9 / Doublesex- and mab-3-related transcription factor C2 / Q8IXT2* / DMRT like family C2*ENSMUSG0000001134918
Dmrta1 / Q8CFG4 / Doublesex- and mab-3-related transcription factor A1 / Q5VZB9* / DMRT like family A1*ENSMUSG0000004375318
Dmrt2 / Q8BG36 / Doublesex- and mab-3-related transcription factor 2 / Q9Y5R5*ENSMUSG0000004813818
Dmrtc1b / DMRTC1* / Q5HYR2* / DMRT like family C1* / DMRT like family C1B*ENSMUSG000000730278
Q9D9R7 / Dmrtc1a / Doublesex- and mab-3-related transcription factor C1 / DMRTC1* / Q5HYR2* / DMRTC1B* / DMRT like family C1* / DMRT like family C1B*ENSMUSG000000313235


Protein motifs (from Interpro)
Interpro ID Name
 IPR001275  DM DNA-binding domain
 IPR026607  DMRT/protein doublesex/protein male abnormal 3
 IPR036407  DM DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0009452 abnormal synaptonemal complex "an anomaly in the formation of the proteinaceous structure involved in the pairing of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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