ENSMUSG00000028668


Mus musculus

Features
Gene ID: ENSMUSG00000028668
  
Biological name :Eloa
  
Synonyms : Eloa / Elongin-A / Q8CB77
  
Possible biological names infered from orthology : Q14241
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D3
Gene start: 136003368
Gene end: 136021763
  
Corresponding Affymetrix probe sets: 10517443 (MoGene1.0st)   1422591_at (Mouse Genome 430 2.0 Array)   1434117_at (Mouse Genome 430 2.0 Array)   1450676_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030427
NCBI entrez gene - 27224     See in Manteia.
MGI - MGI:1351315
RefSeq - NM_013736
RefSeq Peptide - NP_038764
swissprot - Q8CB77
Ensembl - ENSMUSG00000028668
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eloaENSDARG00000102365Danio rerio
 TCEB3ENSGALG00000034625Gallus gallus
 ELOAENSG00000011007Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001810  F-box domain
 IPR003617  Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type
 IPR010684  RNA polymerase II transcription factor SIII, subunit A
 IPR017923  Transcription factor IIS, N-terminal
 IPR035441  TFIIS/LEDGF domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0070449 elongin complex IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA Polymerase II Transcription Elongation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ

 MP:0000597 delayed hepatic development "late onset of the induction and/or differentiation of the liver" [J:18048]
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Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ

 MP:0001889 delayed brain development "the delay or slower progress of the growth and differentiation of the brain" [J:81818, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ

 MP:0002740 heart hypoplasia "decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765]
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Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ

Allelic Composition: Eloatm1Aso/Eloatm1Aso,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ

Allelic Composition: Eloatm1Aso/Eloatm1Aso,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0012703 decreased embryonic neuroepithelium thickness "reduced width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna]
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Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ

Allelic Composition: Eloatm1Aso/Eloatm1Aso,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000055839 Elob / P62869 / Elongin-B / Q15370*  / complex / reaction
 ENSMUSG00000079658 Eloc / P83940 / Elongin-C / Q15369*  / complex / reaction






 

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