ENSMUSG00000028681


Mus musculus

Features
Gene ID: ENSMUSG00000028681
  
Biological name :Ptch2
  
Synonyms : 2 / O35595 / Ptch2
  
Possible biological names infered from orthology : patched 2 / Q9Y6C5
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D1
Gene start: 117096075
Gene end: 117116101
  
Corresponding Affymetrix probe sets: 10507433 (MoGene1.0st)   1422655_at (Mouse Genome 430 2.0 Array)   1457256_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030443
Ensembl peptide - ENSMUSP00000114461
Ensembl peptide - ENSMUSP00000122548
NCBI entrez gene - 19207     See in Manteia.
MGI - MGI:1095405
RefSeq - XM_011240476
RefSeq - NM_008958
RefSeq - XM_011240470
RefSeq - XM_011240471
RefSeq - XM_011240472
RefSeq - XM_011240473
RefSeq - NM_001312903
RefSeq Peptide - NP_001299832
RefSeq Peptide - NP_032984
swissprot - F6XYY1
swissprot - O35595
swissprot - D6RG83
Ensembl - ENSMUSG00000028681
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptch2ENSDARG00000055026Danio rerio
 PTCH2ENSGALG00000010133Gallus gallus
 PTCH2ENSG00000117425Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptch1 / Q61115 / Mus musculus patched 1 (Ptch1), transcript variant 2, mRNA. / Q13635* / patched 1*ENSMUSG0000002146656
Npc1l1 / NPC1 like intracellular cholesterol transporter 1 / Q9UHC9*ENSMUSG0000002044720
Npc1 / O35604 / Niemann-Pick C1 protein / O15118* / NPC intracellular cholesterol transporter 1*ENSMUSG0000002441319
Ptchd3 / Q0EEE2 / patched domain containing 3 / Q3KNS1*ENSMUSG0000003919814
Ptchd1 / Q14B62 / Patched domain-containing protein 1 / Q96NR3* / patched domain containing 1*ENSMUSG0000004155213
Ptchd4 / Mus musculus patched domain containing 4 (Ptchd4), transcript variant 1, mRNA. / Q6ZW05* / patched domain containing 4*ENSMUSG0000004225612


Protein motifs (from Interpro)
Interpro ID Name
 IPR000731  Sterol-sensing domain
 IPR003392  Protein patched/dispatched
 IPR004766  Transmembrane receptor, patched


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001709 cell fate determination IGI
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008544 epidermis development IMP
 biological_processGO:0009957 epidermal cell fate specification IGI
 biological_processGO:0042633 hair cycle IMP
 biological_processGO:0043588 skin development IMP
 biological_processGO:0045606 positive regulation of epidermal cell differentiation IGI
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005119 smoothened binding IEA
 molecular_functionGO:0008158 hedgehog receptor activity IEA
 molecular_functionGO:0097108 hedgehog family protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000172 abnormal bone marrow cell number "Increased or decreased number of cells that make up the core cavities of bones when compared to the norm" [MGI:tc]
Show

Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: Gata6tm2Sad/Gata6tm2Sad
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ptch2tm1Hui/Ptch2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Plgtm1Jld/Plgtm1Jld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NIH Black Swiss

Allelic Composition: Ptch1tm1Mps/Ptch1+,Ptch2tm1Pmc/Ptch2tm1Pmc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001209 spontaneous skin ulceration "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
Show

Allelic Composition: Gata6tm2Sad/Gata6tm2Sad
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ptch2tm1Hui/Ptch2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
Show

Allelic Composition: Gata6tm2Sad/Gata6tm2Sad
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ptch2tm1Hui/Ptch2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Gata6tm2Sad/Gata6tm2Sad
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ptch2tm1Hui/Ptch2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001243 abnormal dermal layer morphology "malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Gata6tm2Sad/Gata6tm2Sad
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Ptch1tm1Mps/Ptch1+,Ptch2tm1Pmc/Ptch2tm1Pmc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002036 rhabdomyosarcoma "malignant tumor derived from skeletal (striated) muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Ptch1tm1Mps/Ptch1+,Ptch2tm1Pmc/Ptch2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ptch1tm1Mps/Ptch1+,Ptch2tm1Pmc/Ptch2tm1Pmc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fbn1tm1Hcd/Fbn1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004175 telangiectases "vascular lesion formed by dilation of a group of small blood vessels" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptch1tm1Mps/Ptch1+,Ptch2tm1Pmc/Ptch2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004208 basal cell carcinoma "a slow-growing, invasive, but usually non-metastasizing neoplasm that originates from basal keratinocytes in the epidermis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptch1tm1Mps/Ptch1+,Ptch2tm1Pmc/Ptch2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ptch1tm1Mps/Ptch1+,Ptch2tm1Pmc/Ptch2tm1Pmc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004478 testicular teratoma "neoplasms found in the testis that are composed of multiple tissue types; includes types not normally found in tesis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ptch1tm1Mps/Ptch1+,Ptch2tm1Pmc/Ptch2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004971 dermal hyperplasia "overdevelopment or increased size, usually due an increased number of cells in the dermal layer of the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata6tm2Sad/Gata6tm2Sad
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ptch2tm1Hui/Ptch2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006283 medulloblastoma "a solid, cancerous tumor originating in the cerebellum of the brain and of primitive neuroectodermal origin " [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptch1tm1Mps/Ptch1+,Ptch2tm1Pmc/Ptch2tm1Pmc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptch1tm1Mps/Ptch1+,Ptch2tm1Pmc/Ptch2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ptch1tm1Mps/Ptch1+,Ptch2tm1Pmc/Ptch2tm1Pmc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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