ENSMUSG00000028950


Mus musculus

Features
Gene ID: ENSMUSG00000028950
  
Biological name :Tas1r1
  
Synonyms : Tas1r1 / taste receptor, type 1, member 1
  
Possible biological names infered from orthology : Q7RTX1 / taste 1 receptor member 1
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 152027914
Gene end: 152038568
  
Corresponding Affymetrix probe sets: 10518869 (MoGene1.0st)   1420432_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030792
NCBI entrez gene - 110326     See in Manteia.
MGI - MGI:1927505
RefSeq - NM_031867
RefSeq Peptide - NP_114073
swissprot - Q3U5H1
Ensembl - ENSMUSG00000028950
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tas1r1ENSDARG00000056739Danio rerio
 TAS1R1ENSGALG00000046030Gallus gallus
 Q7RTX1ENSG00000173662Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q925I4 / Tas1r2 / taste receptor, type 1, member 2 / Q8TE23* / taste 1 receptor member 2*ENSMUSG0000002873837
Q925D8 / Tas1r3 / Taste receptor type 1 member 3 / Q7RTX0* / taste 1 receptor member 3*ENSMUSG0000002907231
Gprc6a / Q8K4Z6 / G protein-coupled receptor, family C, group 6, member A / Q5T6X5* / G protein-coupled receptor class C group 6 member A*ENSMUSG0000001990528
Grm1 / P97772 / Metabotropic glutamate receptor 1 / Q13255* / glutamate metabotropic receptor 1*ENSMUSG0000001982824
Grm3 / Q9QYS2 / Metabotropic glutamate receptor 3 / Q14832* / glutamate metabotropic receptor 3*ENSMUSG0000000397423
Grm2 / Q14BI2 / Metabotropic glutamate receptor 2 / Q14416* / glutamate metabotropic receptor 2*ENSMUSG0000002319223
Grm5 / Q3UVX5 / glutamate receptor, metabotropic 5 / P41594* / glutamate metabotropic receptor 5*ENSMUSG0000004958323
Grm7 / Q68ED2 / Metabotropic glutamate receptor 7 / Q14831* / glutamate metabotropic receptor 7*ENSMUSG0000005675523
Grm4 / glutamate receptor, metabotropic 4 / Q14833* / glutamate metabotropic receptor 4*ENSMUSG0000006323923
Grm6 / Q5NCH9 / Metabotropic glutamate receptor 6 / O15303* / glutamate metabotropic receptor 6*ENSMUSG0000000061722
Grm8 / P47743 / glutamate receptor, metabotropic 8 / O00222* / glutamate metabotropic receptor 8*ENSMUSG0000002421122


Protein motifs (from Interpro)
Interpro ID Name
 IPR000337  GPCR, family 3
 IPR001828  Receptor, ligand binding region
 IPR011500  GPCR, family 3, nine cysteines domain
 IPR017978  GPCR family 3, C-terminal
 IPR017979  GPCR, family 3, conserved site
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0050917 sensory perception of umami taste IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0008527 taste receptor activity IEA


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Pkd1tm2Ggg/Pkd1tm2Ggg,Tg(Nes-cre)Wme/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pkd1tm2Ggg/Pkd1tm2Ggg,Tg(Nes-cre)Wme/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0004213 abnormal unami taste sensitivity "changes in the ability to perceive a particular flavor or suggestion of something unami (savory) by the chemoreceptors of the gustatory system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: GnaqMhdadsk10/Gnaq+
Genetic Background: C3HeB/FeJ-GnaqDsk10

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pkd1tm2Ggg/Pkd1tm2Ggg,Tg(Nes-cre)Wme/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0005423 abnormal somatic nervous system physiology "anomalous function of any of the cranial and spinal nerves or their ganglia or the peripheral sensory receptors" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: GnaqMhdadsk10/Gnaq+
Genetic Background: C3HeB/FeJ-GnaqDsk10

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pkd1tm2Ggg/Pkd1tm2Ggg,Tg(Nes-cre)Wme/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
Show

Allelic Composition: Pkd1tm2Ggg/Pkd1tm2Ggg,Tg(Nes-cre)Wme/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029072 Q925D8 / Tas1r3 / Taste receptor type 1 member 3 / Q7RTX0* / taste 1 receptor member 3*  / complex






 

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