ENSMUSG00000029204


Mus musculus

Features
Gene ID: ENSMUSG00000029204
  
Biological name :Rhoh
  
Synonyms : Q9D3G9 / ras homolog family member H / Rhoh
  
Possible biological names infered from orthology : Q15669
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: C3.1
Gene start: 65861213
Gene end: 65896700
  
Corresponding Affymetrix probe sets: 10522182 (MoGene1.0st)   1429319_at (Mouse Genome 430 2.0 Array)   1441385_at (Mouse Genome 430 2.0 Array)   1443015_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031106
Ensembl peptide - ENSMUSP00000143810
NCBI entrez gene - 74734     See in Manteia.
MGI - MGI:1921984
RefSeq - XM_011240779
RefSeq - NM_001081105
RefSeq Peptide - NP_001074574
swissprot - Q504M6
swissprot - Q9D3G9
Ensembl - ENSMUSG00000029204
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rhohENSDARG00000070121Danio rerio
 ENSGALG00000014277Gallus gallus
 RHOHENSG00000168421Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR003578  Small GTPase superfamily, Rho type
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0030217 T cell differentiation IDA
 biological_processGO:0042326 negative regulation of phosphorylation IEA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
 biological_processGO:0045576 mast cell activation IDA
 cellular_componentGO:0001772 immunological synapse IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding ISO
 molecular_functionGO:0019210 kinase inhibitor activity ISO


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Pitx2tm2Sac/Pitx2+,Tbx1tm1Bem/Tbx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pitx2tm2Sac/Pitx2+,Tbx1tm1Bem/Tbx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0002407 abnormal double-negative T cell "anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gsk3btm1.1Atak/Gsk3b+
Genetic Background: involves: C57BL/6

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Rhohtm1Brak/Rhohtm1Brak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rhohtm1Brak/Rhohtm1Brak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pitx2tm2Sac/Pitx2+,Tbx1tm1Bem/Tbx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Pitx2tm2Sac/Pitx2+,Tbx1tm1Bem/Tbx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gsk3btm1.1Atak/Gsk3b+
Genetic Background: involves: C57BL/6

 MP:0006414 decreased T cell apoptosis "decrease in the number of T cells undergoing programmed cell death" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rhohtm1Brak/Rhohtm1Brak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008039 increased NK T cell number "greater number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008346 increased gamma-delta T cell number "greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Rhohtm1Brak/Rhohtm1Brak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008765 decreased mast cell degranulation "reduction in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gsk3btm1.1Atak/Gsk3b+
Genetic Background: involves: C57BL/6

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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